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Photo of Dr. Keith Pratz

Keith William Pratz, M.D.

Assistant Professor of Oncology


Appointment Phone


Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Assistant Professor of Oncology

Centers & Institutes



Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-502-7726
Fax: 410-614-1005


Hematologic Malignancies, Leukemia, Medical Oncology

Research Interests

Leukemia; My research interests include the development of therapies directed at activated signal transduction systems in cancer. In Acute Myeloid Leukemia (AML) one such activated pathway involves the receptor tyrosine kinase FLT3. FLT3 is mutated in about 1/3 of cases of adult AML and confers a poor prognosis. Several agents are in development targeting FLT3 and our laboratory has developed methods for the determination of the degree to which these compounds inhibit FLT3 over the course of the treatment cycle. We assay target in both circulating leukemia and use a plasma based assay for ex vivo target assessment in patients with insufficient circulating leukemia. We have found that transient inhibition of the target enzyme is associated with inferior clinical responses, and have used this knowledge to modify clinical trial design for improved target modulation. We are currently developing assays for compounds targeting the PI3 kinase pathway and the MEK/AKT pathway and plan on incorporating these correlatives into upcoming clinical trials.

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