Early in his career, Dr. Hogue participated in multiple multicenter clinical investigations in the development of remifentanil and dexmedetomidine that eventually led to their approval for use in the Unites States. He also was an early investigator of the potential use of perfluorocarbon and free hemoglobin based blood substitutes.
More recently Dr. Hogue’s research has focused on neurological complications from cardiac surgery. He was the principle investigator on a National Institutes of Health sponsored clinical trial that investigated the potential role of perioperative estrogen replacement therapy as a means for providing neuroprotection for elderly women undergoing cardiac surgery.
Currently, Dr. Hogue and his colleagues are investigating methods to monitor cerebral blood flow autoregulation noninvasively and in real time.
Dr. Hogue and collaborators at England’s University of Cambridge have developed a method to monitor cerebral autoregulation noninvasively by using near-infrared spectroscopy (NIRS).
Two self-adhesive sensors are placed on the patient’s forehead and connected to an oximetry monitor. Clinical and laboratory research has shown that processing the collected NIRS signals serves as an acceptable surrogate for monitoring changes in cerebral blood flow.
Dr. Hogue and his colleagues believe that this approach can be used to optimize individual patients’ blood pressure to avoid loss of cerebral autoregulation—particularly during cardiac procedures such as cardiopulmonary bypass.
- Joshi B, Ono M, Brown C, Brady K, Easley RB, Yenokyan G, Gottesman RF, Hogue CW. “Predicting the limits of cerebral autoregulation during cardiopulmonary bypass.” Anesth Analg. 2012; 114:503-10.
- Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC. “Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia.” Crit Care Med. 2011 Oct;39(10):2337-45
- Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW Jr. “Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass.” Stroke. 2010 Sep;41(9):1951-6
- Brady KM, Mytar JO, Lee JK, Cameron DE, Vricella LA, Thompson WR, Hogue CW, Easley RB. “Monitoring cerebral blood flow pressure autoregulation in pediatric patients during cardiac surgery.” Stroke. 2010 Sep;41(9):1957-62.
- Mitter N, Shah A, Yuh D, Dodd-o J, Thompson RE, Cameron D, Hogue CW. “Renal injury is associated with operative mortality after cardiac surgery for women and men.” J Thorac Cardiovasc Surg. 2010 Dec;140(6):1367-73.
Pilot Study of the Feasibility of Multicenter NIRS Data Collection and Interventions for Desaturation in Cardiac Surgery
Autoregulation Assessment During Liver Transplantation
Assessing Cerebral Blood Flow Autoregulation During Surgery in the Heads-up Position
Cerebral Autoregulation Monitoring During Cardiac Surgery
Cerebral Blood Flow During Cardiac Surgery and the Presence of Post op Delirium