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Charles Wallace Hogue, MD

Chief, Division of Adult Anesthesia, Department of Anesthesiology and Critical Care Medicine
Professor of Anesthesiology and Critical Care Medicine
Male
Appointment Phone

410-955-7519

Main Location

The Johns Hopkins Hospital

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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Chief, Division of Adult Anesthesia, Department of Anesthesiology and Critical Care Medicine
  • Professor of Anesthesiology and Critical Care Medicine

Expertise

Anesthesiology

Research Interests

Cardiovascular anesthesiology; Thoracic anesthesiology; Cerebral blood flow monitoring; Cerebral autoregulation; Near-infrared spectroscopy (NIRS); Brain injury; Kidney injury

Biography

Dr. Charles W. Hogue Jr. is a professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. A specialist in cardiovascular and thoracic anesthesiology, Dr. Hogue serves as chief of the Division of Adult Anesthesia.

Dr. Hogue’s research focuses on methods for improving outcomes from cardiovascular surgery—with a particular focus on brain and kidney injury. He is currently funded by the National Institutes of Health, American Heart Association and Anesthesia Patient Safety Foundation to explore novel methods of monitoring cerebral blood flow autoregulation as a means for reducing the frequency of surgery-related neurological complications.

He earned his medical degree magna cum laude at the University of Illinois College of Medicine. He completed an anesthesiology residency at The Massachusetts General Hospital/Harvard Medical School. He was a clinical fellow at Harvard Medical School and a research fellow at Shriners Burns Institute. Dr. Hogue joined the Johns Hopkins faculty in 2005.

Dr. Hogue has published more than 120 peer-reviewed articles and book chapters and co-authored three books. In addition to presenting scores of invited lectures and presentations, he has been a visiting professor at some of the nation’s most prestigious academic medical centers.

Languages

  • English

Memberships

International Anesthesia Research Society

American Society of Anesthesiologists

Society of Cardiovascular Anesthesiologists

Association of University Anesthesiologists

American Medical Association

Maryland Society of Anesthesiologists

Alpha Omega Alpha

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Illinois College of Medicine (Chicago IL) (1986)

    Residencies

    • Massachusetts General Hospital / Anesthesiology (Boston MA) (1990)

    Certifications

    • General, American Board of Anesthesiology / Anesthesiology (2008)
  • Research & Publications +

    Research Summary

    Early in his career, Dr. Hogue participated in multiple multicenter clinical investigations in the development of remifentanil and dexmedetomidine that eventually led to their approval for use in the Unites States. He also was an early investigator of the potential use of perfluorocarbon and free hemoglobin based blood substitutes.

    More recently Dr. Hogue’s research has focused on neurological complications from cardiac surgery. He was the principle investigator on a National Institutes of Health sponsored clinical trial that investigated the potential role of perioperative estrogen replacement therapy as a means for providing neuroprotection for elderly women undergoing cardiac surgery.

    Currently, Dr. Hogue and his colleagues are investigating methods to monitor cerebral blood flow autoregulation noninvasively and in real time.

    Dr. Hogue and collaborators at England’s University of Cambridge have developed a method to monitor cerebral autoregulation noninvasively by using near-infrared spectroscopy (NIRS).

    Two self-adhesive sensors are placed on the patient’s forehead and connected to an oximetry monitor. Clinical and laboratory research has shown that processing the collected NIRS signals serves as an acceptable surrogate for monitoring changes in cerebral blood flow.

    Dr. Hogue and his colleagues believe that this approach can be used to optimize individual patients’ blood pressure to avoid loss of cerebral autoregulation—particularly during cardiac procedures such as cardiopulmonary bypass.

    Selected Publications

    1. Joshi B, Ono M, Brown C, Brady K, Easley RB, Yenokyan G, Gottesman RF, Hogue CW. “Predicting the limits of cerebral autoregulation during cardiopulmonary bypass.” Anesth Analg. 2012; 114:503-10.
    2. Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC. “Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia.” Crit Care Med. 2011 Oct;39(10):2337-45
    3. Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW Jr. “Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass.” Stroke. 2010 Sep;41(9):1951-6
    4. Brady KM, Mytar JO, Lee JK, Cameron DE, Vricella LA, Thompson WR, Hogue CW, Easley RB. “Monitoring cerebral blood flow pressure autoregulation in pediatric patients during cardiac surgery.” Stroke. 2010 Sep;41(9):1957-62.
    5. Mitter N, Shah A, Yuh D, Dodd-o J, Thompson RE, Cameron D, Hogue CW. “Renal injury is associated with operative mortality after cardiac surgery for women and men.” J Thorac Cardiovasc Surg. 2010 Dec;140(6):1367-73.

    Lab

    Dr. Charles Hogue's Lab

    Clinical Trials

    Pilot Study of the Feasibility of Multicenter NIRS Data Collection and Interventions for Desaturation in Cardiac Surgery

    Autoregulation Assessment During Liver Transplantation

    Assessing Cerebral Blood Flow Autoregulation During Surgery in the Heads-up Position

    Cerebral Autoregulation Monitoring During Cardiac Surgery

    Cerebral Blood Flow During Cardiac Surgery and the Presence of Post op Delirium

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Third place, Resident Research Essay Contest, American Society of Anesthesiologists, 1990

    Second place, Resident Research Contest, Anesthesiology, Harvard Medical School, 1990

    Second place, Resident Research Essay Contest, American Society of Anesthesiologists, 1989

    First place, Resident Research Contest, Anesthesiology, Harvard Medical School, 1988

    Finalist, William Grove Award for Outstanding Senior, College of Medicine, University of Illinois, 1986

    Otto Saphir Award for Outstanding Student in Pathology, University of Illinois, 1985

    Alpha Omega Alpha Honor Medical Society, University of Illinois, 1985

    John Rutherford Ott Award for Outstanding Student in Biology, Southern Illinois University, 1982

    Professional Activities

    Associate Editor-in-Chief for Cardiovascular Anesthesiology, Anesthesia & Analgesia, 2006 - present

    Editorial board, Journal of Thoracic and Cardiovascular Surgery, 2003 - present

    Peer reviewer, Anesthesiology, Annals of Thoracic Surgery, Journal of Thoracic and Cardiovascular Surgery, Circulation, and Stroke

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-955-7519
    Appointment Phone: 410-955-7519
    Fax: 410-955-0994
    Location Map

    Department/Division

    • Anesthesiology and Critical Care Medicine - Cardiac Anesthesia

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