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Charles W. Hogue, Jr, M.D.

Photo of Dr. Charles W. Hogue, Jr, M.D.

Chief, Division of Adult Anesthesia, Department of Anesthesiology and Critical Care Medicine

Professor of Anesthesiology and Critical Care Medicine


Expertise: Anesthesiology

Research Interests: Kidney injury; Brain injury; Near-infrared spectroscopy (NIRS); Cerebral autoregulation; Cerebral blood flow monitoring; Thoracic anesthesiology; Cardiovascular anesthesiology more


The Johns Hopkins Hospital
Appointment Phone: 410-955-7519

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-7519
Fax: 410-955-0994


Dr. Charles W. Hogue Jr. is a professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. A specialist in cardiovascular and thoracic anesthesiology, Dr. Hogue serves as chief of the Division of Adult Anesthesia.

Dr. Hogue’s research focuses on methods for improving outcomes from cardiovascular surgery—with a particular focus on brain and kidney injury. He is currently funded by the National Institutes of Health, American Heart Association and Anesthesia Patient Safety Foundation to explore novel methods of monitoring cerebral blood flow autoregulation as a means for reducing the frequency of surgery-related neurological complications.

He earned his medical degree magna cum laude at the University of Illinois College of Medicine. He completed an anesthesiology residency at The Massachusetts General Hospital/Harvard Medical School. He was a clinical fellow at Harvard Medical School and a research fellow at Shriners Burns Institute. Dr. Hogue joined the Johns Hopkins faculty in 2005.

Dr. Hogue has published more than 120 peer-reviewed articles and book chapters and co-authored three books. In addition to presenting scores of invited lectures and presentations, he has been a visiting professor at some of the nation’s most prestigious academic medical centers. more


  • Chief, Division of Adult Anesthesia, Department of Anesthesiology and Critical Care Medicine
  • Professor of Anesthesiology and Critical Care Medicine

Departments / Divisions

Research & Publications

Research Summary

Early in his career, Dr. Hogue participated in multiple multicenter clinical investigations in the development of remifentanil and dexmedetomidine that eventually led to their approval for use in the Unites States. He also was an early investigator of the potential use of perfluorocarbon and free hemoglobin based blood substitutes.

More recently Dr. Hogue’s research has focused on neurological complications from cardiac surgery. He was the principle investigator on a National Institutes of Health sponsored clinical trial that investigated the potential role of perioperative estrogen replacement therapy as a means for providing neuroprotection for elderly women undergoing cardiac surgery.

Currently, Dr. Hogue and his colleagues are investigating methods to monitor cerebral blood flow autoregulation noninvasively and in real time.

Dr. Hogue and collaborators at England’s University of Cambridge have developed a method to monitor cerebral autoregulation noninvasively by using near-infrared spectroscopy (NIRS).

Two self-adhesive sensors are placed on the patient’s forehead and connected to an oximetry monitor. Clinical and laboratory research has shown that processing the collected NIRS signals serves as an acceptable surrogate for monitoring changes in cerebral blood flow.

Dr. Hogue and his colleagues believe that this approach can be used to optimize individual patients’ blood pressure to avoid loss of cerebral autoregulation—particularly during cardiac procedures such as cardiopulmonary bypass.


Clinical Trials

Pilot Study of the Feasibility of Multicenter NIRS Data Collection and Interventions for Desaturation in Cardiac Surgery

Autoregulation Assessment During Liver Transplantation

Assessing Cerebral Blood Flow Autoregulation During Surgery in the Heads-up Position

Cerebral Autoregulation Monitoring During Cardiac Surgery

Cerebral Blood Flow During Cardiac Surgery and the Presence of Post op Delirium

Selected Publications

  1. Joshi B, Ono M, Brown C, Brady K, Easley RB, Yenokyan G, Gottesman RF, Hogue CW. "Predicting the limits of cerebral autoregulation during cardiopulmonary bypass." Anesth Analg. 2012; 114:503-10.
  2. Lee JK, Brady KM, Mytar JO, Kibler KK, Carter EL, Hirsch KG, Hogue CW, Easley RB, Jordan LC, Smielewski P, Czosnyka M, Shaffner DH, Koehler RC. "Cerebral blood flow and cerebrovascular autoregulation in a swine model of pediatric cardiac arrest and hypothermia." Crit Care Med. 2011 Oct;39(10):2337-45
  3. Brady K, Joshi B, Zweifel C, Smielewski P, Czosnyka M, Easley RB, Hogue CW Jr. "Real-time continuous monitoring of cerebral blood flow autoregulation using near-infrared spectroscopy in patients undergoing cardiopulmonary bypass." Stroke. 2010 Sep;41(9):1951-6
  4. Brady KM, Mytar JO, Lee JK, Cameron DE, Vricella LA, Thompson WR, Hogue CW, Easley RB. "Monitoring cerebral blood flow pressure autoregulation in pediatric patients during cardiac surgery." Stroke. 2010 Sep;41(9):1957-62.
  5. Mitter N, Shah A, Yuh D, Dodd-o J, Thompson RE, Cameron D, Hogue CW. "Renal injury is associated with operative mortality after cardiac surgery for women and men." J Thorac Cardiovasc Surg. 2010 Dec;140(6):1367-73.

Activities & Honors


  • Third place Resident Research Essay Contest, American Society of Anesthesiologists, 1990
  • Second place Resident Research Contest, Harvard Medical School, 1990
  • Second place Resident Research Essay Contest, American Society of Anesthesiologists, 1989
  • First place Resident Research Contest, Harvard Medical School, 1988
  • Finalist William Grove Award for Outstanding Senior, University of Illinois, 1986
  • Otto Saphir Award for Outstanding Student in Pathology, University of Illinois, 1985
  • Alpha Omega Alpha Honor Medical Society, University of Illinois, 1985
  • John Rutherford Ott Award for Outstanding Student in Biology, Southern Illinois University, 1982


  • Alpha Omega Alpha
  • American Medical Association
  • American Society of Anesthesiologists
  • Association of University Anesthesiologists
  • International Anesthesia Research Society
  • Maryland Society of Anesthesiologists
  • Society of Cardiovascular Anesthesiologists

Professional Activities

  • Associate Editor-in-Chief for¬†Cardiovascular Anesthesiology, Anesthesia & Analgesia, 2006
  • Editorial board, Journal of Thoracic and Cardiovascular Surgery, 2003
  • Peer reviewer, Anesthesiology
  • Peer reviewer, Annals of Thoracic Surgery
  • Peer reviewer, Journal of Thoracic and Cardiovascular Surgery
  • Peer reviewer, Circulation
  • Peer reviewer, Stroke
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