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Georges Jabboure Netto, MD

Professor of Pathology
Male
Appointment Phone

410-955-3580

Primary Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Professor of Pathology
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

  • James Buchanan Brady Urological Institute

Expertise

Pathology

Research Interests

Urologic malignancies; Molecular biomarkers; Prostate cancer; Kidney cancer; Bladder cancer; Testicular cancer; Prostatic intraepithelial neoplasia; Secondary tumors of the GU system; Prognostic and targeted therapies

Biography

Dr. Georges J. Netto is a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine. An expert in the histologic interpretation of surgical biopsies the urologic and male genital organs, Dr. Netto is a consultant in the nationally recognized Johns Hopkins Urologic Pathology Laboratory.

Dr. Netto earned his medical degree from Syria’s University of Damascus and completed an anatomic and clinical pathology residency at Baylor University Medical Center. He completed subspecialty training in oncologic and urologic pathology at Barnes Hospital in St. Louis and Memorial Sloan-Kettering Cancer Center. He joined the Johns Hopkins faculty in 2005.

He is board-certified in anatomic and clinical pathology, as well as in molecular genetic pathology, a new pathology discipline focused on developing molecular-based tests (DNA/RNA) for diagnosing and predicting the course of cancer.

In addition to publishing scores of academic articles, Dr. Netto co-authored Biopsy Interpretation of the Prostate with Hopkins colleague Jonathan Epstein, M.D. He has lectured worldwide on the diagnostic and molecular aspects of urologic pathology.

He has served as a reviewer for publications that include Cancer, The Journal of Urology, Urology, Modern Pathology, Archives of Pathology & Laboratory Medicine, Laboratory Investigation and Human Pathology.

Dr. Netto speaks English, Arabic and French.

Languages

  • English
  • Arabic
  • French

Memberships

College of American Pathology

American Society of Clinical Pathology

Association of Molecular Pathology

American College of Medical Genetics

International Academy of Pathology

International Academy of Pathology (Arab Division)

Additional Resources +
  • Education +

    Training

    • Damascus University ( Damascus) (1985)

    Residencies

    • Baylor University Medical Center/Anatomic and Clinical Pathology ( Dallas TX ) (1992)

    Fellowships

    • Memorial Sloan - Kettering Cancer Center ( New York NY ) (1994)
    • Barnes - Jewish Hospital/Anatomic Pathology ( St Louis MO ) (1993)

    Certifications

    • Molecular Genetic Pathology, American Board of Pathology (2005)
    • Anatomic & Clinical Pathology, American Board of Pathology (1992)
  • Research & Publications +

    Research Summary

    Dr. Netto’s current research focuses on the evaluation of molecular biomarkers that can serve as potential prognosticators or therapeutic targets in the management of urologic malignancies.

    These studies are facilitated by the construction of tissue microarrays coupled with image-analysis technology to be used for immunohistochemistry and FISH analysis of prostatic, bladder, renal and testicular cancers. He also focuses on the molecular diagnostic applications with potential roles in screening and early detection of urologic malignancies.

    Ongoing prostate cancer studies are evaluating the role of TMPRSS2-ERG translocation, proliferation markers and mTOR pathway members in predicting prostate cancer progression. The studies are funded by grants from the Prostate Cancer Foundation and the Patrick C. Walsh Foundation, as well as with an NIH/NCI-sponsored Johns Hopkins Prostate SPORE grant.

    Studies on urothelial carcinoma involve evaluation of biomarkers in a newly constructed tissue array from a well characterized cohort of cystectomy patients treated at the Brady Urological Institute. Markers being studied include cell-cycle control elements, EGFR expression and mutation analysis, PIK3CA mutation analysis, DNA damage-response elements and mTOR pathway members.

    These studies are supported by a 2008 FAMRI Clinical Innovator Award, philanthropic Bladder Fund and NIH/NCI sponsored grants including a PO1 program award.

    Additional urologic oncology studies are examining biomarkers of targeted therapies in renal-cell carcinoma, including TOPOIIa, HIF1a/VEGF and mTOR pathway.

    Selected Publications

    1. Klock C, Gomes R, João M, Netto G. Prostate Melanosis Associated With Acinar Adenocarcinoma. Int J Surg Pathol. 2010 Oct;18(5):379-80. doi: 10.1177/1066896908329591.
    2. Albadine R, Wang W, Brownlee NA, Toubaji A, Billis A, Epstein JI, Argani P, Garvin AJ, Couzi R, Schaeffer E, Pavlovich CP, Netto GJ. "Topoisomerase IIA Status in Renal Medullary Carcinoma: Immunoexpression and Gene Copy Alterations of a Potential Target of Therapy. J Urol. 2009 Aug;182(2):735-40. doi: 10.1016/j.juro.2009.03.078.
    3. K Fujita, CP Pavlovich, G Netto, Y Konishi, WB Isaacs, S Ali, A De Marzo and A Meeker. "Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology." Hum Pathol. 2009 Jul;40(7):924-33. doi: 10.1016/j.humpath.2009.01.004. Epub 2009 Apr 14.
    4. Lotan TL, Toubaji A, Albadine R, Latour M, Herawi M, Meeker AK, De Marzo AM, Platz EA, Epstein JI, Netto GJ. "TMPRSS2-ERG Gene Fusions are Infrequent in Prostatic Ductal Adenocarcinomas." Modern Pathol. 2009 Mar;22(3):359-65. doi: 10.1038/modpathol.2008.236.
    5. Cheung WL, Albadine R, Chan T, Sharma R, Netto GJ. "Phosphorylated H2AX in Non-Invasive Low Grade Urothelial Carcinoma of Urinary Bladder: Correlation with Tumor Recurrence." J Urol. 2009 Mar;181(3):1387-92. doi: 10.1016/j.juro.2008.10.146. Epub 2009 Jan 20.
  • Academic Affiliations & Courses +
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  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-3580
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-955-3580
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-955-3580
    Location Map

    Department/Division

    • Pathology

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