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Photo of Dr. Georges Netto

Georges Jabboure Netto, M.D.

Professor of Pathology

Male  | Languages: English, Arabic, French

Appointment Phone

410-955-3580

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Professor of Pathology
  • Professor of Oncology
  • Professor of Urology

Centers & Institutes

Departments

  • Oncology - Prostate Cancer/GU
  • Pathology - Kidney-Urologic Pathology
  • Urology

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-955-3580

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-3580

601 N. Caroline Street
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-955-3580

4940 Eastern Avenue
Baltimore, MD 21224 map

Expertise

Pathology

Research Interests

Prognostic and targeted therapies; Secondary tumors of the GU system; Prostatic intraepithelial neoplasia; Testicular cancer; Bladder cancer; Kidney cancer; Prostate cancer; Molecular biomarkers; Urologic malignancies

Biography

Dr. Georges J. Netto is a professor of pathology, oncology and urology at the Johns Hopkins School of Medicine. An expert in the histologic interpretation of surgical biopsies the urologic and male genital organs, Dr. Netto is a consultant in the nationally recognized Johns Hopkins Urologic Pathology Laboratory.

Dr. Netto earned his medical degree from Syria’s University of Damascus and completed an anatomic and clinical pathology residency at Baylor University Medical Center. He completed subspecialty training in oncologic and urologic pathology at Barnes Hospital in St. Louis and Memorial Sloan-Kettering Cancer Center. He joined the Johns Hopkins faculty in 2005.

He is board-certified in anatomic and clinical pathology, as well as in molecular genetic pathology, a new pathology discipline focused on developing molecular-based tests (DNA/RNA) for diagnosing and predicting the course of cancer.

In addition to publishing scores of academic articles, Dr. Netto co-authored Biopsy Interpretation of the Prostate with Hopkins colleague Jonathan Epstein, M.D. He has lectured worldwide on the diagnostic and molecular aspects of urologic pathology.

He has served as a reviewer for publications that include Cancer, The Journal of Urology, Urology, Modern Pathology, Archives of Pathology & Laboratory Medicine, Laboratory Investigation and Human Pathology.

Dr. Netto speaks English, Arabic and French.

...read more

    Additional Information

  • Education +

    Degrees

    • Damascus University / MD (1985)

    Residencies

    • Baylor University Medical Center / Anatomic and Clinical Pathology (1992)

    Fellowships

    • Barnes-Jewish Hospital / Anatomic Pathology (1993)
    • Memorial Sloan-Kettering Cancer Center (1994)

    Certifications

    • American Board of Pathology / Anatomic & Clinical Pathology (1992)
    • American Board of Pathology / Molecular Genetic Pathology (2005)
  • Research & Publications +

    Research Summary

    Dr. Netto’s current research focuses on the evaluation of molecular biomarkers that can serve as potential prognosticators or therapeutic targets in the management of urologic malignancies.

    These studies are facilitated by the construction of tissue microarrays coupled with image-analysis technology to be used for immunohistochemistry and FISH analysis of prostatic, bladder, renal and testicular cancers. He also focuses on the molecular diagnostic applications with potential roles in screening and early detection of urologic malignancies.

    Ongoing prostate cancer studies are evaluating the role of TMPRSS2-ERG translocation, proliferation markers and mTOR pathway members in predicting prostate cancer progression. The studies are funded by grants from the Prostate Cancer Foundation and the Patrick C. Walsh Foundation, as well as with an NIH/NCI-sponsored Johns Hopkins Prostate SPORE grant.

    Studies on urothelial carcinoma involve evaluation of biomarkers in a newly constructed tissue array from a well characterized cohort of cystectomy patients treated at the Brady Urological Institute. Markers being studied include cell-cycle control elements, EGFR expression and mutation analysis, PIK3CA mutation analysis, DNA damage-response elements and mTOR pathway members.

    These studies are supported by a 2008 FAMRI Clinical Innovator Award, philanthropic Bladder Fund and NIH/NCI sponsored grants including a PO1 program award.

    Additional urologic oncology studies are examining biomarkers of targeted therapies in renal-cell carcinoma, including TOPOIIa, HIF1a/VEGF and mTOR pathway.

    Selected Publications

    1. Klock C, Gomes R, João M, Netto G. Prostate Melanosis Associated With Acinar Adenocarcinoma. Int J Surg Pathol. 2010 Oct;18(5):379-80. doi: 10.1177/1066896908329591.
    2. Albadine R, Wang W, Brownlee NA, Toubaji A, Billis A, Epstein JI, Argani P, Garvin AJ, Couzi R, Schaeffer E, Pavlovich CP, Netto GJ. "Topoisomerase IIA Status in Renal Medullary Carcinoma: Immunoexpression and Gene Copy Alterations of a Potential Target of Therapy. J Urol. 2009 Aug;182(2):735-40. doi: 10.1016/j.juro.2009.03.078.
    3. K Fujita, CP Pavlovich, G Netto, Y Konishi, WB Isaacs, S Ali, A De Marzo and A Meeker. "Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology." Hum Pathol. 2009 Jul;40(7):924-33. doi: 10.1016/j.humpath.2009.01.004. Epub 2009 Apr 14.
    4. Lotan TL, Toubaji A, Albadine R, Latour M, Herawi M, Meeker AK, De Marzo AM, Platz EA, Epstein JI, Netto GJ. "TMPRSS2-ERG Gene Fusions are Infrequent in Prostatic Ductal Adenocarcinomas." Modern Pathol. 2009 Mar;22(3):359-65. doi: 10.1038/modpathol.2008.236.
    5. Cheung WL, Albadine R, Chan T, Sharma R, Netto GJ. "Phosphorylated H2AX in Non-Invasive Low Grade Urothelial Carcinoma of Urinary Bladder: Correlation with Tumor Recurrence." J Urol. 2009 Mar;181(3):1387-92. doi: 10.1016/j.juro.2008.10.146. Epub 2009 Jan 20.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Memberships

    • American College of Medical Genetics
    • American Society of Clinical Pathology
    • Association of Molecular Pathology
    • College of American Pathology
    • International Academy of Pathology
    • International Academy of Pathology (Arab Division)
  • Videos & Media +
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