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Photo of Dr. Alfredo Quinones-Hinojosa

Alfredo Quinones-Hinojosa, M.D.

Director, Brain Tumor Surgery Program
Professor of Neurosurgery

Male  | Languages: English, Spanish

Appointment Phone

410-550-3367

Main Location

Johns Hopkins Bayview Medical Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Director, Brain Tumor Surgery Program
  • Director, Pituitary Surgery Program
  • Director, Neurosurgery Brain Tumor Stem Cell Laboratory
  • Professor of Neurosurgery
  • Professor of Neuroscience
  • Professor of Oncology

Centers & Institutes

Departments

  • Neuroscience
  • Neurosurgery - Brain Tumor
  • Oncology - Brain Cancer

Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-3367

4940 Eastern Avenue
301 Mason F. Lord Drive Suite 2100
Baltimore, MD 21224 map
Phone: 410-550-3367
Fax: 410-550-0748

The Johns Hopkins Hospital

Appointment Phone: 410-955-6406

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-6406

601 N. Caroline Street
Baltimore, MD 21287 map

The Johns Hopkins Hospital

600 N. Wolfe Street
Halstead
Baltimore, MD 21287 map

Expertise

Brain Cancer, Brain Stem Tumors, Brain Tumors, Endoscopy, Glioblastoma, Neurosurgery , Pituitary Tumors, Skull Base Surgery, Skull Base Tumors

Research Interests

Stem cells in relation to the origin of brain tumors, and the potential role stem cells can play in fighting brain cancer and regaining neurological function; Neuro-Oncology Surgical Outcomes Research: working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors

Biography

At Johns Hopkins, Dr. Alfredo Quinones is a Professor of Neurosurgery and Oncology, Neuroscience and Cellular and Molecular Medicine. In addition to directing the Brain Tumor Surgery Program at Johns Hopkins Bayview Hospital, and the Pituitary Surgery Program at the Johns Hopkins Hospital, Dr. Quinones leads the Brain Tumor Stem Cell Laboratory.

Dr. Alfredo Quinones focuses on the surgical treatment of primary and metastatic brain tumors, with an emphasis on motor and speech mapping during surgery, as well as in the treatment of patients with pituitary and skull base tumors using transphenoidal endonasal and minimally invasive surgical approaches.

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    Additional Information

  • Education +

    Degrees

    • Harvard Medical School / MD (1999)

    Residencies

    • University of California San Francisco / Neurosurgery (2005)

    Certifications

    • American Board of Neurological Surgery / Neurological Surgery (2010)

    Additional Training

    Fellowship, University of California San Francisco (San Francisco CA ) (2005)

  • Research & Publications +

    Research Summary

    Dr. Quinones conducts numerous research efforts on elucidating the role of stem cells in the origin of brain tumors and the potential role stem cells can play in fighting brain cancer and regaining neurological function. In addition to leading the Brain Tumor Stem Cell Laboratory, he also heads the Neuro-Oncology Surgical Outcomes Research Laboratory where he is working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors.

    Lab:

    Neuro-Oncology Surgical Outcomes Research Laboratory

    The Neuro-Oncology Outcomes Research Laboratory aims to identify pre- and post-operative treatment measures that influence hospital-based morbidity and mortality in an effort to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors. The Outcomes Lab also aims to discover novel clinical, radiographic, and physiological parameters that may influence survival in patients with malignant brain tumors.

    Brain Tumor Stem Cell Laboratory

    For many patients afflicted with brain cancer, brain tumors are lethal and cause loved ones untold emotional suffering. The identification of successful treatments for brain cancer remains a challenging task. Our laboratory studies the organization and cytoarchitecture of the subventricular zone as a niche of stem cells and a potential source of tumors in the human brain. Understanding the relationship between this area of the brain and the genesis of brain tumors is of paramount importance. Our goal is to understand the function of these human brain stem cells and how they may play a role in the origin of brain tumors. Consequently, we ultimately aim for the ability to manipulate the microenvironments of these cells in order to find better therapies to fight brain cancer.

    Lab Website: Neuro-Oncology Surgical Outcomes Research Laboratory

    Selected Publications View all on PubMed

    Chaichana, K.L.; Capilla-Gonzalez, V.; Gonzalez-Perez, O.; Pradilla, G.; Han, J.; Olivi, A.; Brem, H.; Garcia-Verdugo, J.M.; Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. Journal of neuroscience methods. 2007 Aug 30;164(2):261-270.

    Attenello, F.J.; Mukherjee, D.; Datoo, G.; McGirt, M.J.; Bohan, E.; Weingart, J.D.; Olivi, A.; Quinones-Hinojosa, A.; Brem, H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Annals of surgical oncology. 2008 Oct;15(10):2887-2893.

    McGirt, M.J.; Chaichana, K.L.; Attenello, F.J.; Weingart, J.D.; Than, K.; Burger, P.C.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008 Oct;63(4):700-707; author reply 707-708.

    Chaichana, K.L.; McGirt, M.J.; Niranjan, A.; Olivi, A.; Burger, P.C.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literature. Neurological research. 2009 Nov;31(9):931-939.

    Chaichana, K.L.; Parker, S.L.; Olivi, A.; Quinones-Hinojosa, A. Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article. Journal of neurosurgery. 2009 Aug;111(2):282-292.

    Gathinji, M.; McGirt, M.J.; Attenello, F.J.; Chaichana, K.L.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg Neurol. 2009 Mar;71(3):299-303, discussion 303.

    McGirt, M.J.; Chaichana, K.L.; Gathinji, M.; Attenello, F.J.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A.R. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Journal of neurosurgery. 2009 Jan;110(1):156-162.

    McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.

    Sun, P.; Xia, S.; Lal, B.; Eberhart, C.G.; Quinones-Hinojosa, A.; Maciaczyk, J.; Matsui, W.; Dimeco, F.; Piccirillo, S.M.; Vescovi, A.L.; Laterra, J. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009 Jul;27(7):1473-1486.

    Achanta, P.; Sedora Roman, N.I.; Quinones-Hinojosa, A. Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer agents in medicinal chemistry. 2010;10(2):121-130.

    Chaichana, K.; Parker, S.; Olivi, A.; Quinones-Hinojosa, A. A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. Journal of neurosurgery. 2010;112(5):997-1004.

    Chaichana, K.L.; Kosztowski, T.; Niranjan, A.; Olivi, A.; Weingart, J.D.; Laterra, J.; Brem, H.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. Journal of neurosurgery. 2010;113(2):286-292.

    Chaichana, K.L.; McGirt, M.J.; Laterra, J.; Olivi, A.; Quinones-Hinojosa, A. Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. Journal of neurosurgery. 2010;112(1):10-17.

    Chaichana, K.L.; McGirt, M.J.; Woodworth, G.F.; Datoo, G.; Tamargo, R.J.; Weingart, J.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurological research. 2010;32(4):442-448.

    Frazier, J.L.; Johnson, M.W.; Burger, P.C.; Weingart, J.D.; Quinones-Hinojosa, A. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World neurosurgery. 2010;73(1):53-62; discussion e55.

    Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).

    Hales, R.K.; Shokek, O.; Burger, P.C.; Paynter, N.P.; Chaichana, K.L.; Quinones-Hinojosa, A.; Jallo, G.I.; Cohen, K.J.; Song, D.Y.; Carson, B.S.; Wharam, M.D. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. Journal of neuro-oncology. 2010;99(1):65-71.

    Hughes, S.A.; Achanta, P.; Ho, A.L.; Duenas, V.J.; Quinones-Hinojosa, A. Biological horizons for targeting brain malignancy. Advances in Experimental Medicine and Biology. 2010;671(Journal Article):93-104.

    Mukherjee, D.; Chang, D.C.; Quinones-Hinojosa, A. New methods to assess trends in neuro-oncological care. Journal of neuro-oncology. 2010;97(1):155-156.

    Mukherjee, D.; Zaidi, H.A.; Kosztowski, T.; Chaichana, K.L.; Brem, H.; Chang, D.C.; Quinones-Hinojosa, A. Disparities in access to neuro-oncologic care in the United States. Archives of surgery (Chicago, Ill: 1960). 2010;145(3):247-253.

    Ying, M.; Sang, Y.; Li, Y.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Vescovi, A.L.; Eberhart, C.G.; Xia, S.; Laterra, J. KLF9, A Differentiation-Associated Transcription Factor, Suppresses Notch1 Signaling and Inhibits Glioblastoma-Initiating Stem Cells. Stem cells. 2010;Epub 11/18/10(Journal Article).

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Commencement address, Southern Vermont College
    • Honorary Doctor of Humane Letters, Southern Vermont College
    • Martinez and Townsel Endowed Lecture, Marine Biological Laboratory
    • MBL Friday Night Lecture, Marine Biological Laboratory
    • Top 100 Most Influential Hispanics in the U.S., Hispanic Business Journal, 2007
    • United States Brilliant 10 Scientists, Popular Science Magazine, 2007
    • National Leadership in Science and Medicine Award, Merage Foundation and the Woodrow Wilson International Center for Scholars, 2008
    • California Community College Distinguished Alumni Award, 2009
    • Invited keynote speaker, Success for All Foundation Annual Convention¬†, 2011

    Professional Activities

    • Invited Scientist, 2010 Nifty Fifty USA Science and Engineering Festival, 2010
  • Videos & Media +

    Videos

    Patient Story: Sacral Chordoma

    Patient Story: Pituitary Tumor

    Patient Story: Skull Base Meningioma Tumor

    Recent News Articles & Media Coverage

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