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Alfredo Quinones-Hinojosa, M.D.

Photo of Dr. Alfredo Quinones-Hinojosa, M.D.

Director, Brain Tumor Surgery Program

Professor of Neurosurgery


Languages: English, Spanish

Expertise: Brain Cancer, Brain Stem Tumors, Brain Tumors, Endoscopy, Glioblastoma, Neurosurgery, Pituitary Tumors, Skull Base Surgery, Skull Base Tumors more

Research Interests: Stem cells in relation to the origin of brain tumors; potential role stem cells can play in fighting brain cancer ; regaining neurological function; Neuro-Oncology Surgical Outcomes Research; working to improve patient safety; maximize the efficacy of current treatment paradigms for patients with brain tumors more

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Johns Hopkins Bayview Medical Center
Appointment Phone: 410-550-3367

301 Mason Lord Drive
Baltimore, MD 21224 map
Phone: 410-550-3367
Fax: 410-550-0748

The Johns Hopkins Hospital
Appointment Phone: 410-955-6406

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Outpatient Center
Appointment Phone: 410-955-6406

601 N. Caroline St.
Baltimore, MD 21287 map


At Johns Hopkins, Dr. Alfredo Quinones is a Professor of Neurosurgery and Oncology, Neuroscience and Cellular and Molecular Medicine. In addition to directing the Brain Tumor Surgery Program at Johns Hopkins Bayview Hospital, and the Pituitary Surgery Program at the Johns Hopkins Hospital, Dr. Quinones leads the Brain Tumor Stem Cell Laboratory.

Dr. Alfredo Quinones focuses on the surgical treatment of primary and metastatic brain tumors, with an emphasis on motor and speech mapping during surgery, as well as in the treatment of patients with pituitary and skull base tumors using transphenoidal endonasal and minimally invasive surgical approaches. more


  • Director, Brain Tumor Surgery Program
  • Director, Pituitary Surgery Program
  • Director, Neurosurgery Brain Tumor Stem Cell Laboratory
  • Professor of Neurosurgery
  • Professor of Neuroscience
  • Professor of Oncology

Departments / Divisions



  • MD, Harvard Medical School (1999)


  • University of California San Francisco / Neurosurgery (2005)

Board Certifications

  • American Board of Neurological Surgery / Neurological Surgery (2010)

Additional Training

Fellowship, University of California San Francisco (San Francisco CA ) (2005)

Research & Publications

Research Summary

Dr. Quinones conducts numerous research efforts on elucidating the role of stem cells in the origin of brain tumors and the potential role stem cells can play in fighting brain cancer and regaining neurological function. In addition to leading the Brain Tumor Stem Cell Laboratory, he also heads the Neuro-Oncology Surgical Outcomes Research Laboratory where he is working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors.


Neuro-Oncology Surgical Outcomes Research Laboratory

The Neuro-Oncology Outcomes Research Laboratory aims to identify pre- and post-operative treatment measures that influence hospital-based morbidity and mortality in an effort to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors. The Outcomes Lab also aims to discover novel clinical, radiographic, and physiological parameters that may influence survival in patients with malignant brain tumors.

Brain Tumor Stem Cell Laboratory

For many patients afflicted with brain cancer, brain tumors are lethal and cause loved ones untold emotional suffering. The identification of successful treatments for brain cancer remains a challenging task. Our laboratory studies the organization and cytoarchitecture of the subventricular zone as a niche of stem cells and a potential source of tumors in the human brain. Understanding the relationship between this area of the brain and the genesis of brain tumors is of paramount importance. Our goal is to understand the function of these human brain stem cells and how they may play a role in the origin of brain tumors. Consequently, we ultimately aim for the ability to manipulate the microenvironments of these cells in order to find better therapies to fight brain cancer.

Lab Website: Brain Stem Cell Lab

Selected Publications

View all on Pubmed

Chaichana, K.L.; Capilla-Gonzalez, V.; Gonzalez-Perez, O.; Pradilla, G.; Han, J.; Olivi, A.; Brem, H.; Garcia-Verdugo, J.M.; Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. Journal of neuroscience methods. 2007 Aug 30;164(2):261-270.

Attenello, F.J.; Mukherjee, D.; Datoo, G.; McGirt, M.J.; Bohan, E.; Weingart, J.D.; Olivi, A.; Quinones-Hinojosa, A.; Brem, H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Annals of surgical oncology. 2008 Oct;15(10):2887-2893.

McGirt, M.J.; Chaichana, K.L.; Attenello, F.J.; Weingart, J.D.; Than, K.; Burger, P.C.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008 Oct;63(4):700-707; author reply 707-708.

Chaichana, K.L.; McGirt, M.J.; Niranjan, A.; Olivi, A.; Burger, P.C.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literature. Neurological research. 2009 Nov;31(9):931-939.

Chaichana, K.L.; Parker, S.L.; Olivi, A.; Quinones-Hinojosa, A. Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article. Journal of neurosurgery. 2009 Aug;111(2):282-292.

Gathinji, M.; McGirt, M.J.; Attenello, F.J.; Chaichana, K.L.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg Neurol. 2009 Mar;71(3):299-303, discussion 303.

McGirt, M.J.; Chaichana, K.L.; Gathinji, M.; Attenello, F.J.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A.R. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Journal of neurosurgery. 2009 Jan;110(1):156-162.

McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.

Sun, P.; Xia, S.; Lal, B.; Eberhart, C.G.; Quinones-Hinojosa, A.; Maciaczyk, J.; Matsui, W.; Dimeco, F.; Piccirillo, S.M.; Vescovi, A.L.; Laterra, J. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009 Jul;27(7):1473-1486.

Achanta, P.; Sedora Roman, N.I.; Quinones-Hinojosa, A. Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer agents in medicinal chemistry. 2010;10(2):121-130.

Chaichana, K.; Parker, S.; Olivi, A.; Quinones-Hinojosa, A. A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. Journal of neurosurgery. 2010;112(5):997-1004.

Chaichana, K.L.; Kosztowski, T.; Niranjan, A.; Olivi, A.; Weingart, J.D.; Laterra, J.; Brem, H.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. Journal of neurosurgery. 2010;113(2):286-292.

Chaichana, K.L.; McGirt, M.J.; Laterra, J.; Olivi, A.; Quinones-Hinojosa, A. Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. Journal of neurosurgery. 2010;112(1):10-17.

Chaichana, K.L.; McGirt, M.J.; Woodworth, G.F.; Datoo, G.; Tamargo, R.J.; Weingart, J.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurological research. 2010;32(4):442-448.

Frazier, J.L.; Johnson, M.W.; Burger, P.C.; Weingart, J.D.; Quinones-Hinojosa, A. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World neurosurgery. 2010;73(1):53-62; discussion e55.

Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).

Hales, R.K.; Shokek, O.; Burger, P.C.; Paynter, N.P.; Chaichana, K.L.; Quinones-Hinojosa, A.; Jallo, G.I.; Cohen, K.J.; Song, D.Y.; Carson, B.S.; Wharam, M.D. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. Journal of neuro-oncology. 2010;99(1):65-71.

Hughes, S.A.; Achanta, P.; Ho, A.L.; Duenas, V.J.; Quinones-Hinojosa, A. Biological horizons for targeting brain malignancy. Advances in Experimental Medicine and Biology. 2010;671(Journal Article):93-104.

Mukherjee, D.; Chang, D.C.; Quinones-Hinojosa, A. New methods to assess trends in neuro-oncological care. Journal of neuro-oncology. 2010;97(1):155-156.

Mukherjee, D.; Zaidi, H.A.; Kosztowski, T.; Chaichana, K.L.; Brem, H.; Chang, D.C.; Quinones-Hinojosa, A. Disparities in access to neuro-oncologic care in the United States. Archives of surgery (Chicago, Ill: 1960). 2010;145(3):247-253.

Ying, M.; Sang, Y.; Li, Y.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Vescovi, A.L.; Eberhart, C.G.; Xia, S.; Laterra, J. KLF9, A Differentiation-Associated Transcription Factor, Suppresses Notch1 Signaling and Inhibits Glioblastoma-Initiating Stem Cells. Stem cells. 2010;Epub 11/18/10(Journal Article).

Activities & Honors


  • Martinez and Townsel Endowed Lecture, Marine Biological Laboratory
  • MBL Friday Night Lecture, Marine Biological Laboratory
  • Honorary Doctor of Humane Letters, Southern Vermont College
  • Commencement address, Southern Vermont College
  • Invited keynote speaker, Success for All Foundation Annual Convention¬†, 2011
  • United States Brilliant 10 Scientists, Popular Science Magazine, 2007
  • Top 100 Most Influential Hispanics in the U.S., Hispanic Business Journal, 2007
  • National Leadership in Science and Medicine Award, Merage Foundation and the Woodrow Wilson International Center for Scholars, 2008
  • California Community College Distinguished Alumni Award, 2009

Professional Activities

  • Invited Scientist, 2010 Nifty Fifty USA Science and Engineering Festival, 2010

Videos & Media

Patient Story: Sacral Chordoma

Patient Story: Pituitary Tumor

Patient Story: Skull Base Meningioma Tumor

Doorways to Discovery: Shutting Down Energy to Glioblastomas

Recent News Articles and Media Coverage

Technology May Help Surgeons Tell Brain Cancer From Healthy Tissue, U.S. News & World Report (06/19/2015)

New imaging technique could make brain tumor removal safer, more effective, study suggests, Medical Xpress (06/18/2015)

Glioblastoma’s Energy No More? NeuroLogic (Spring 2015)

Shutting Down Energy to Brain Cancer, Bioscience Technology (11/05/2014)

Clarksburg man shows courage when faced with cancer, Maryland Gazette (09/24/2014)
"Dr. Q", un puente entre México y Estados Unidos, El Universal (01/20/2014)

From Migrant Worker to Neurosurgeon, CNN (05/23/2013)

Press release: Using Fat to Fight Brain Cancer (03/13/2013)

Press release: Research Yields New Clues to How Brain Cancer Cells Migrate and Invade (05/02/2012)

Johns Hopkins doctors do brain surgery via eyelid, Baltimore Sun (06/26/2010)

Recorded online seminar: I Was Diagnosed with a Pituitary TumorNow What?

Podcast: Brain Surgery - Awake Craniotomy

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