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Photo of Dr. Alfredo Quinones-Hinojosa

Alfredo Quinones-Hinojosa, MD

Director, Brain Tumor Surgery Program
Professor of Neurological Surgery

See Research on Pubmed | See Research on Google Scholar

Male
Appointment Phone

410-550-3367

Main Location

Johns Hopkins Bayview Medical Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Brain Tumor Surgery Program
  • Director, Pituitary Surgery Program
  • Director, Neurosurgery Brain Tumor Stem Cell Laboratory
  • Professor of Neurological Surgery
  • Professor of Oncology

Centers & Institutes

  • Armstrong Institute for Patient Safety and Quality
  • Cell Engineering, Institute for
  • Comprehensive Brain Tumor Center
  • Neuro-Oncology Surgical Outcomes Research Laboratory
  • Neurosurgery Brain Tumor Stem Cell Laboratory
  • Pituitary Center
  • Sidney Kimmel Comprehensive Cancer Center
  • Skull Base Tumor Center

Expertise

Brain Cancer, Brain Stem Tumors, Brain Tumors, Endoscopy, Glioblastoma, Neurosurgery, Pituitary Tumors, Skull Base Surgery, Skull Base Tumors

Research Interests

Neuro-Oncology Surgical Outcomes Research: working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors; Stem cells in relation to the origin of brain tumors, and the potential role stem cells can play in fighting brain cancer and regaining neurological function

Biography

At Johns Hopkins, Dr. Alfredo Quinones is a Professor of Neurosurgery and Oncology, Neuroscience and Cellular and Molecular Medicine. In addition to directing the Brain Tumor Surgery Program at Johns Hopkins Bayview Hospital, and the Pituitary Surgery Program at the Johns Hopkins Hospital, Dr. Quinones leads the Brain Tumor Stem Cell Laboratory.

Dr. Alfredo Quinones focuses on the surgical treatment of primary and metastatic brain tumors, with an emphasis on motor and speech mapping during surgery, as well as in the treatment of patients with pituitary and skull base tumors using transphenoidal endonasal and minimally invasive surgical approaches.
Additional Resources +
  • Education +

    Training

    • Harvard Medical School (Boston MA) (1999)

    Residencies

    • University of California San Francisco / Neurosurgery (San Francisco CA) (2005)

    Fellowships

    • University of California San Francisco (San Francisco CA) (2005)

    Certifications

    • American Board of Neurological Surgery / Neurological Surgery (2010)
  • Research & Publications +

    Research Summary

    Dr. Quinones conducts numerous research efforts on elucidating the role of stem cells in the origin of brain tumors and the potential role stem cells can play in fighting brain cancer and regaining neurological function. In addition to leading the Brain Tumor Stem Cell Laboratory, he also heads the Neuro-Oncology Surgical Outcomes Research Laboratory where he is working to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors.

    Selected Publications View all on PubMed

    Chaichana, K.L.; Capilla-Gonzalez, V.; Gonzalez-Perez, O.; Pradilla, G.; Han, J.; Olivi, A.; Brem, H.; Garcia-Verdugo, J.M.; Quinones-Hinojosa, A. Preservation of glial cytoarchitecture from ex vivo human tumor and non-tumor cerebral cortical explants: A human model to study neurological diseases. Journal of neuroscience methods. 2007 Aug 30;164(2):261-270.

    Attenello, F.J.; Mukherjee, D.; Datoo, G.; McGirt, M.J.; Bohan, E.; Weingart, J.D.; Olivi, A.; Quinones-Hinojosa, A.; Brem, H. Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience. Annals of surgical oncology. 2008 Oct;15(10):2887-2893.

    McGirt, M.J.; Chaichana, K.L.; Attenello, F.J.; Weingart, J.D.; Than, K.; Burger, P.C.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas. Neurosurgery. 2008 Oct;63(4):700-707; author reply 707-708.

    Chaichana, K.L.; McGirt, M.J.; Niranjan, A.; Olivi, A.; Burger, P.C.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing low-grade gliomas in adults and a review of the literature. Neurological research. 2009 Nov;31(9):931-939.

    Chaichana, K.L.; Parker, S.L.; Olivi, A.; Quinones-Hinojosa, A. Long-term seizure outcomes in adult patients undergoing primary resection of malignant brain astrocytomas. Clinical article. Journal of neurosurgery. 2009 Aug;111(2):282-292.

    Gathinji, M.; McGirt, M.J.; Attenello, F.J.; Chaichana, K.L.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A. Association of preoperative depression and survival after resection of malignant brain astrocytoma. Surg Neurol. 2009 Mar;71(3):299-303, discussion 303.

    McGirt, M.J.; Chaichana, K.L.; Gathinji, M.; Attenello, F.J.; Than, K.; Olivi, A.; Weingart, J.D.; Brem, H.; Quinones-Hinojosa, A.R. Independent association of extent of resection with survival in patients with malignant brain astrocytoma. Journal of neurosurgery. 2009 Jan;110(1):156-162.

    McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.

    Sun, P.; Xia, S.; Lal, B.; Eberhart, C.G.; Quinones-Hinojosa, A.; Maciaczyk, J.; Matsui, W.; Dimeco, F.; Piccirillo, S.M.; Vescovi, A.L.; Laterra, J. DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation. Stem Cells. 2009 Jul;27(7):1473-1486.

    Achanta, P.; Sedora Roman, N.I.; Quinones-Hinojosa, A. Gliomagenesis and the use of neural stem cells in brain tumor treatment. Anti-cancer agents in medicinal chemistry. 2010;10(2):121-130.

    Chaichana, K.; Parker, S.; Olivi, A.; Quinones-Hinojosa, A. A proposed classification system that projects outcomes based on preoperative variables for adult patients with glioblastoma multiforme. Journal of neurosurgery. 2010;112(5):997-1004.

    Chaichana, K.L.; Kosztowski, T.; Niranjan, A.; Olivi, A.; Weingart, J.D.; Laterra, J.; Brem, H.; Quinones-Hinojosa, A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. Journal of neurosurgery. 2010;113(2):286-292.

    Chaichana, K.L.; McGirt, M.J.; Laterra, J.; Olivi, A.; Quinones-Hinojosa, A. Recurrence and malignant degeneration after resection of adult hemispheric low-grade gliomas. Journal of neurosurgery. 2010;112(1):10-17.

    Chaichana, K.L.; McGirt, M.J.; Woodworth, G.F.; Datoo, G.; Tamargo, R.J.; Weingart, J.; Olivi, A.; Brem, H.; Quinones-Hinojosa, A. Persistent outpatient hyperglycemia is independently associated with survival, recurrence and malignant degeneration following surgery for hemispheric low grade gliomas. Neurological research. 2010;32(4):442-448.

    Frazier, J.L.; Johnson, M.W.; Burger, P.C.; Weingart, J.D.; Quinones-Hinojosa, A. Rapid malignant transformation of low-grade astrocytomas: report of 2 cases and review of the literature. World neurosurgery. 2010;73(1):53-62; discussion e55.

    Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).

    Hales, R.K.; Shokek, O.; Burger, P.C.; Paynter, N.P.; Chaichana, K.L.; Quinones-Hinojosa, A.; Jallo, G.I.; Cohen, K.J.; Song, D.Y.; Carson, B.S.; Wharam, M.D. Prognostic factors in pediatric high-grade astrocytoma: the importance of accurate pathologic diagnosis. Journal of neuro-oncology. 2010;99(1):65-71.

    Hughes, S.A.; Achanta, P.; Ho, A.L.; Duenas, V.J.; Quinones-Hinojosa, A. Biological horizons for targeting brain malignancy. Advances in Experimental Medicine and Biology. 2010;671(Journal Article):93-104.

    Mukherjee, D.; Chang, D.C.; Quinones-Hinojosa, A. New methods to assess trends in neuro-oncological care. Journal of neuro-oncology. 2010;97(1):155-156.

    Mukherjee, D.; Zaidi, H.A.; Kosztowski, T.; Chaichana, K.L.; Brem, H.; Chang, D.C.; Quinones-Hinojosa, A. Disparities in access to neuro-oncologic care in the United States. Archives of surgery (Chicago, Ill: 1960). 2010;145(3):247-253.

    Ying, M.; Sang, Y.; Li, Y.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Vescovi, A.L.; Eberhart, C.G.; Xia, S.; Laterra, J. KLF9, A Differentiation-Associated Transcription Factor, Suppresses Notch1 Signaling and Inhibits Glioblastoma-Initiating Stem Cells. Stem cells. 2010;Epub 11/18/10(Journal Article).

    Lab

    Neuro-Oncology Surgical Outcomes Research Laboratory

    The Neuro-Oncology Outcomes Research Laboratory aims to identify pre- and post-operative treatment measures that influence hospital-based morbidity and mortality in an effort to improve patient safety and maximize the efficacy of current treatment paradigms for patients with brain tumors. The Outcomes Lab also aims to discover novel clinical, radiographic, and physiological parameters that may influence survival in patients with malignant brain tumors.

    Brain Tumor Stem Cell Laboratory

    For many patients afflicted with brain cancer, brain tumors are lethal and cause loved ones untold emotional suffering. The identification of successful treatments for brain cancer remains a challenging task. Our laboratory studies the organization and cytoarchitecture of the subventricular zone as a niche of stem cells and a potential source of tumors in the human brain. Understanding the relationship between this area of the brain and the genesis of brain tumors is of paramount importance. Our goal is to understand the function of these human brain stem cells and how they may play a role in the origin of brain tumors. Consequently, we ultimately aim for the ability to manipulate the microenvironments of these cells in order to find better therapies to fight brain cancer.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    2011: Invited keynote speaker for Success for All Foundation Annual Convention Martinez and Townsel Endowed Lecture at the Marine Biological Laboratory MBL Friday Night Lecture at the Marine Biological Laboratory Honorary Doctor of Humane Letters at Southern Vermont College Commencement address at Southern Vermont Colleges 84th Commencement ceremony

    Professional Activities

    Dr. Alfredo Quinones-Hinojosa has been named one of the United States Brilliant 10 Scientists by Popular Science Magazine (2007) as well as one of the Top 100 Most Influential Hispanics in the U.S. by the Hispanic Business Journal (2007). He received the 2008 National Leadership in Science and Medicine Award by the Merage Foundation and the Woodrow Wilson International Center for Scholars in Washington, DC. Dr. Quinones was awarded the California Community College Distinguished Alumni Award in 2009 and participated as an invited scientist at the 2010 Nifty Fifty USA Science and Engineering Festival in 2010. In addition, he has been awarded many prestigious grants including awards from The Howard Hughes Medical Institute, Robert Wood Foundation, and Maryland Stem Cell Research Fund.
  • Videos & Media +

    Videos

    Meet our Experts: Dr. Alfredo Quinones-Hinojosa

    Dr. Alfredo Quiones-Hinojosa focuses on the neurosurgical treatment of primary and metastatic brain tumors, pituitary and skull base tumors using minimally invasive approaches.

    Patient Story: Skull Base Meningioma Tumor

    Sharon and her physicians, neurosurgeon Dr. Alfredo Quinones and facial plastic surgeon, Dr. Kofi Boahene, share how they removed a skull base meningioma tumor through her eyelid.

    Patient Story: Pituitary Tumor

    Yanir shares his story on his diagnosis of a rare TSH-secreting (thyroid-stimulating hormone) pituitary tumor that required immediate brain surgery to save his sight and life.

    Video Links

    Recent News Articles & Media Coverage

    Shutting Down Energy to Brain Cancer, Bioscience Technology (11/05/2014)

    Clarksburg man shows courage when faced with cancer, Maryland Gazette (09/24/2014)

    "Dr. Q", un puente entre México y Estados Unidos, El Universal (01/20/2014)

    From Migrant Worker to Neurosurgeon, CNN (05/23/2013)

    Press release: Using Fat to Fight Brain Cancer (03/13/2013)

    Press release: Research Yields New Clues to How Brain Cancer Cells Migrate and Invade (05/02/2012)

    Johns Hopkins doctors do brain surgery via eyelid, Baltimore Sun (06/26/2010)

  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    301 Mason Lord Drive
    2100
    Baltimore, MD 21224
    Phone: 410-550-3367
    Appointment Phone: 410-550-3367
    Fax: 410-550-0748
    Location Map
    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-955-6406
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-955-6406
    Location Map

    Department/Division

    • Neurosurgery - Neuro-Oncology
    • Neurosurgery - Brain Tumor
    • Neurosurgery - Neurological Surgery

    For Research Inquiries Contact

    Email Dr. Q: aquinon2@jhmi.edu

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