Dr. Romero focuses his efforts on the study of pituitary hormone deficiency in children and the regulation of the somatotroph. One area of his research involves recruiting children with multiple pituitary hormone deficiencies and studying various pituitary transcription factors known to be important in pituitary development. The goal is to help identify genetic mutations using novel technology such as next generation sequencing that may be responsible for pituitary disease in children with hormone deficiency with unknown cause.
In addition, Dr. Romero’s research has led to the development of novel mouse model systems that allow him to study the regulation of the somatotroph, which is important in the production of growth hormone.
Avtanski D, Novaira HJ, Wu S, Romero CJ, Kineman R, Luque RM, Wondisford F, Radovick S. "Both estrogen receptor α and β stimulate pituitary GH gene expression." Mol Endocrinol. 2014 Jan;28(1):40-52. doi: 10.1210/me.2013-1245. Epub 2013 Jan 1.
Iwama S, Welt CK, Romero CJ, Radovick S, Caturegli P. "Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells." J Clin Endocrinol Metab. 2013 Oct;98(10):3920-5. doi: 10.1210/jc.2013-2411. Epub 2013 Aug 12. Erratum in: J Clin Endocrinol Metab. 2013 Dec;98(12):4992.
Pine-Twaddell E, Romero CJ, Radovick S. "Vertical transmission of hypopituitarism: critical importance of appropriate interpretation of thyroid function tests and levothyroxine therapy during pregnancy." Thyroid. 2013 Jul;23(7):892-7. doi: 10.1089/thy.2012.0332. Epub 2013 Jun 21.
Romero CJ, Pine-Twaddell E, Sima DI, Miller RS, He L, Wondisford F, Radovick S. "Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions." Mol Cell Biol. 2012 Nov;32(21):4258-69. doi: 10.1128/MCB.00171-12. Epub 2012 Aug 13.
Gorbenko Del Blanco D, Romero CJ, Diaczok D, de Graaff LC, Radovick S, Hokken-Koelega AC. "A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve." Eur J Endocrinol. 2012 Sep;167(3):441-52. doi: 10.1530/EJE-12-0333. Epub 2012 Jun 19.