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Fredric Edward Wondisford, M.D.

Director, Division of Metabolism, Johns Hopkins Children’s Center


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Director, Division of Metabolism, Johns Hopkins Children’s Center
  • Director, Johns Hopkins Diabetes Initiative
  • Director, JHU-UMD Diabetes Research and Training Center

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-955-9270

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-502-5761

Johns Hopkins Outpatient Center

Appointment Phone: 410-955-9270

601 N. Caroline Street
Baltimore, MD 21287 map



Research Interests

Thyroid hormone resistance syndrome, Gene expression regulation, Hormone regulation, Growth factor regulation


Dr. Frederic E. Wondisford is a professor of pediatrics, physiology and medicine at the Johns Hopkins University School of Medicine. A specialist in endocrinology and metabolism, Dr. Wondisford is the director of the Johns Hopkins Diabetes Initiative. This multidisciplinary effort integrates and expands on the many diabetes-related patient care, research and educational activities under way in the Johns Hopkins Health System.

Dr. Wondisford is the director of the JHU-UMD Diabetes Research Center, at which investigators conduct multidisciplinary diabetes and endocrinology research that is translated into programs to teach clinicians to better diagnose and manage diabetes. He is also the director of the Division of Metabolism at the John’s Hopkins Children’s Center. 

He earned his medical degree at Northeastern Ohio Universities College of Medicine. He completed a residency at Case Western Reserve University Hospitals and an endocrinology fellowship at the National Institutes of Health. He joined Johns Hopkins in 2005 from the University of Chicago, where he led its Division of Endocrinology and Metabolism and directed its Diabetes Research and Training Center. 

He has a broad range of research interests related to endocrinology and metabolism, and has published more than 120 scholarly articles. He received the Barry Wood Award for Excellence in Teaching from Johns Hopkins University School of Medicine in 2014. more

    Additional Information

  • Education +


    • Northeastern Ohio Universities College of Medicine / MD (1983)


    • National Institutes of Health / Endocrinology (1990)


    • American Board of Internal Medicine / Endocrinology and Metabolism (1989)
    • American Board of Internal Medicine / Internal Medicine (1986)
  • Research & Publications +

    Research Summary

    Dr. Wondisford’s research interests include:

    • Pituitary and hypothalamic gene expression and molecular mechanisms responsible for hormonal regulation
    • Growth-factor regulation of the anterior pituitary gland and pancreas
    • Molecular mechanism of thyroid hormone action in the brain
    • Role of co-activators in pancreatic B-cell transcription and development
    • Molecular mechanism of peroxisome proliferator-activated receptor gamma (PPARg) action in the adipocyte
    • Regulation of hepatic gluconeogenesis by transcriptional co-factors

    Selected Publications

    Sinkevicius KW, Burdette JE, Woloszyn K, Hewitt SC, Hamilton K, Sugg SL, Temple KA, Wondisford FE, Korach KS, Woodruff TK, Greene GL. "An estrogen receptor-alpha knock-in mutation provides evidence of ligand-independent signaling and allows modulation of ligand-induced pathways in vivo." Endocrinology. 2008;149(6):2970-9.

    Pessôa CN, Santiago LA, Santiago DA, Machado DS, Rocha FAF, Ventura DF, Hokoç JN, Pazos-Moura CC, Wondisford FE, Gardino PF, Ortiga-Carvalho TM. "Thyroid hormone action is required for normal cone opsin expression during mouse retinal development." Investigative ophthalmology & visual science. 2008;49(5):2039-45.

    Divall SA, Wondisford FE. "TRH testing in its infancy." The Journal of clinical endocrinology and metabolism. 2008;93(2):378-9.

    Applebury ML, Farhangfar F, Glösmann M, Hashimoto K, Kage K, Robbins JT, Shibusawa N, Wondisford F E, Zhang H. "Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis." Developmental dynamics : an official publication of the American Association of Anatomists. 2007;236(5):1203-12.

    Hussain MA, Porras DL, Rowe MH, West JR, Song WJ, Schreiber WE, Wondisford FE. "Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation." Molecular and cellular biology. 2006;26(20):7747-59.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Barry Wood Award for Excellence in Teaching, Johns Hopkins University School of Medicine, 2014
  • Videos & Media +
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