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Sally Radovick, M.D.

Director of Pediatric Endocrinology
Professor of Pediatrics

Female

Appointment Phone

410-955-6463

Main Location

Johns Hopkins Pediatric Specialty Clinic

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Titles

  • Director of Pediatric Endocrinology
  • Lawson Wilkins Professor
  • Professor of Pediatrics

Centers & Institutes

Departments

  • Pediatrics - Endocrinology

Locations

Johns Hopkins Pediatric Specialty Clinic

Appointment Phone: 410-955-6463

200 N. Wolfe Street
Rubenstein Child Health Suite 3120
Baltimore, MD 21287 map
Phone: 410-955-6463
Fax: 410-955-9773

Contact for Research Inquiries

RESEARCH OFFICE

600 N. Wolfe Street
CMSC 406
Baltimore, MD 21287 map

Expertise

Hypopituitarism, Pediatric Endocrinology, Pubertal Conditions

Research Interests

Regulation of the gonadotropin-releasing hormone (GnRH) gene by sex steroids, neurotransmitters, and growth factors; Prevention of obesity and diabetes in children; The molecular basis of hypogonadotropic hypogonadism; The developmental biology of hypothalamic and pituitary neuroendocrine cells; The molecular basis of hypopituitarism

Biography

Dr. Sally Radovick is a professor of pediatrics at the Johns Hopkins University School of Medicine. She is the Lawson Wilkins Professor of Pediatrics, director of the Division of Pediatric Endocrinology at Johns Hopkins Children’s and vice chair for research in the Department of Pediatrics.

 

Dr. Radovick received her medical degree from Northeastern Ohio Universities College of Medicine. She then completed her residency in pediatrics at Case Western Reserve University and her fellowship in pediatric endocrinology at the National Institutes of Health (NIH).

She has outstanding credentials in academic leadership, research and teaching, for which she has received national and international recognition. She is a specialist in growth and development and pubertal disorders in children. Since joining Hopkins in 2005, she has built the Pediatric Endocrinology program from six to 12 faculty members and expanded the training program from three to five fellows.

Her research has focused on the development, regulation, of hypothalamic-pituitary function. One area of this research focuses on the developmental regulation of the gonadotropin-releasing hormone (GnRH) neuron. Dr. Radovick's laboratory has demonstrated that the GnRH gene is the target of growth factor and nuclear hormone signaling pathways, which link nutrition and growth with pubertal development and reproduction. Her studies have shown that obesity in children and adolescence is associated with increases in disorders of puberty and infertility. 

Dr. Radovick started the Baltimore-Chicago Center for Reproductive Research with a prestigious grant from the Specialized Cooperative Centers Program for Reproductive Research. Dr. Radovick is the director of the Pilot and Feasibility Program and co-director of the Transgenic Core for the NIH-funded Diabetes Research and Training Center.

She has authored or co-authored more than 150 peer-reviewed scientific publications, and has been invited to write a dozen chapters in her area. She is also the senior editor of the book Clinical Management of Pediatric Endocrine Disorders in 2003, with a second edition in 2013. She served as the associate editor for Pediatric Endocrinology for the Journal of Clinical Endocrinology and Metabolism.

Dr. Radovick participates in teaching of undergraduates, medical students, residents, and endocrinology fellows. Her most notable teaching efforts have been in training individuals for scientific research, and she is particularly interested in nurturing the careers of junior faculty. She actively participates in clinical activities, holding pediatric endocrinology teaching clinics. 

Dr. Radovick was recognized among the Best Doctors in America (Woodward-White) and in Baltimore Magazine as a clinical pediatric endocrinologist.

...read more

    Additional Information

  • Education +

    Degrees

    • Northeastern Ohio Universities College of Medicine / MD (1983)

    Fellowships

    • National Institutes of Health-Credentialing Services Section / Pediatric Endocrinology (1990)

    Certifications

    • American Board of Pediatrics / Pediatric Endocrinology (1989, 2011)
    • American Board of Pediatrics / Pediatrics (1988)
  • Research & Publications +

    Research Summary

    Dr. Radovick’s research focuses on the development, regulation and dysregulation of hypothalamic-pituitary function, for which she is currently 95 percent funded by the NIH.

    Her research centers on determining the regulation of the gonadotropin-releasing hormone (GnRH) gene. It has a central role in reproduction by controlling secretion of luteinizing hormone (LH) and follicle stimulating hormone (FSH), which in turn regulate the synthesis of estrogen and androgen. Her group was one of the first to generate GnRH-expressing neuronal cell-lines and map GnRH cell-specific elements in vivo. She also studies intracellular signaling pathways within the GnRH neuron. Her lab demonstrated that insulin-like growth factor (IGF-1) receptors were present on GnRH neurons obtained from transgenic animals and their activation results in increased transcription of the GnRH gene. This pathway may be an important mediator of GnRH expression in normal puberty as well as in disorders resulting in abnormal pubertal development and reproduction.

    The other major area of this research has been to characterize the transcription factors important for normal pituitary development. Her initial studies provided the first description in man of the molecular genetic mechanism for combined pituitary hormone deficiency; this involved a mutation in the Pit-1 gene that is necessary for the differentiation of the somatotroph (growth hormone-producing cell), lactotroph (prolactin) and thyrotroph (thyrotropin) lineages. More recently, her laboratory has begun investigation into the molecular mechanisms by which mutations in other transcription factors important for pituitary development exert their effects.

    Clinical Trials:

    Function of Metformin at the Cellular Level and Best Dosing for Children and Adults With DM or Pre-DM


    Selected Publications

    Pine-Twaddell ED, Romero CJ, Radovick S. "Vertical transmission of hypopituitarism: Critical importance of appropriate interpretation of thyroid function tests and levothyroxine therapy during pregnancy." Thyroid. 2013 Feb 11. PMID: 23397938

    Novaira HJ, Fadoju D, Diaczok D, Radovick S. "Genetic mechanisms mediating kisspeptin regulation of GnRH gene expression." J Neurosci. 2012, 32(48):17391-400. PMID: 23197730.

    Romero CJ, Pine-Twaddell E, Sima DI, Miller RS, He L, Wondisford F, Radovick S. "Insulin-like growth factor-mediates negative feedback to somatotroph GH expression via POU1F1/CREB-binding protein interactions." Mol Cell Biol. 2012, 32(21):4258-69. PMID: 22890843

    He L, Naik K, Meng S, Cao J, Sidhaye AR, Ma A, Radovick S, Wondisford FE. "Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis." J Biol Chem. 2012, 14;287(38):32069-77. PMID: 22815486

    Raivio T, Avbelj M, McCabe MJ, Romero CJ, Dwyer AA, Tommiska J, Sykiotis GP, Gregory LC, Diaczok D, Tziaferi V, Elting MW, Padidela R, Plummer L, Martin C, Feng B, Zhang C, Zhou QY, Chen H, Mohammadi M, Quinton R, Sidis Y, Radovick S, Dattani MT, Pitteloud N. "Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia." J Clin Endocrinol Metab. 2012, 97(4):E694-9. PMID: 22319038

    Diaczok D, Mammen J, Novaira HJ, Kim HH, Wolfe A, Radovick S. Loss of Otx2 in GnRH neurons results in reproductive dysfunction. Submitted

    Chen, M. Wolfe, A, Wang, X, Chang, C., Yeh, S, Radovick, S. Generation and Characterization of a Complete Null ERα Mouse Using Cre/LoxP Technology. Mol Cell Biochem. Jan;321(1-2):145-53, 2009.

    Chen, M., Hsu, I, Wolfe, A., Radovick, S., Lin, C-Y., Chang, Cl, Messing, E., Ye, S. Defects of Prostate Development and Reproductive System in the ERα Null Male Mice. Endocrinol Jan;150(1):251-9, 2009.

    DiVall SA, Radovick S. Endocrinology of female puberty. Curr Opin Endocrinol Diabetes Obes. Feb;16(1):1-4, 2009.

    Ng Y, Wolfe A, Novaira HJ, Radovick S. Estrogen Regulation of Gene Expression in GnRH Neurons. Ng and Wolfe contributed equally to this work, in press at Molecular and Cellular Endocrinology.

    Singh SP, Wolfe A, DiVall SA, Radovick S. Conditional knock-out of the estrogen receptor alpha gene in the reproductive axis, in revision, Bio Reprod.

    Novaira HJ, Ng Y, Wolfe A, Radovick S. Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines. Submitted.

    Radovick S, DiVall S. Approach to the growth hormone-deficient child during transition to adulthood. J Clin Endocrinol Metab. 92(4):1195-200, 2007.

    Miller R, Radovick S. Does treatment of childhood congenital adrenal hyperplasia with prednisone adversely affect final height? Nat Clin Pract Endocrinol Metab. 3(9):626-7, 2007.

    Wolfe A, DiVall SA, Singh SP, Nikrodhanond AA, Baria AT, Le WW, Hoffman GE, Radovick S. Temporal and Saptial Regulation of CRE Recombinase Expression in Gonadotrophin-Releasing Hormone Neurons in the Mouse. J Neuroendocrinol. 20(7):909-16, 2008.

    Wolfe A, Ng Y, DiVall SA, Singh SP, Radovick S. Development of an Immortalised, Post-Pubertal GnRH Neuronal Cell Line. J Neuroendocrinol, 20(9):1029-37, 2008.

    Diaczok D, Romero C, Zunich J, Marshall I, Radovick S. A novel dominant negative mutation of OTX2 associated with combined pituitary hormone deficiency. J Clin Endocrinol Metab, 93(11):4351-9, 2008.

    DiVall SA, Radovick S. Pubertal development and menarche. Ann N Y Acad Sci, 1135:19-28, 2008.

    Cohen RN, Brue T, Naik K, Houlihan CA, Wondisford FE, Radovick S. The role of CBP/p300 interactions and Pit-1 dimerization in the pathophysiological mechanism of combined pituitary hormone deficiency. J Clin Endocrinol Metab. 91(1):239-47, 2006.

    Buggs C, Weinberg F, Kim E, Wolfe A, Radovick S, Wondisford F. Insulin augments GnRH-stimulated LHbeta gene expression by Egr-1. Mol Cell Endocrinol. 249(1-2):99-106, 2006.

    Divall SA, Radovick S. Deciphering the genetics of stature-another piece of the puzzle. J Clin Endocrinol Metab. 91(4):1218-9, 2006.

    Kim HH, Wolfe A, Cohen RN, Eames SC, Johnson AL, Wieland CN, Radovick S. In vivo identification of a 107-base pair promoter element mediating neuron-specific expression of mouse gonadotropin-releasing hormone. Mol Endocrinol. 21(2):457-71, 2007.

    Naik K, Pittman I 4th, Wolfe A, Miller RS, Radovick S, Wondisford FE. A novel technique for temporally regulated cell type-specific Cre expression and recombination in the pituitary gonadotroph. J Mol Endocrinol. 37(1):63-9, 2007.

    DiVall SA, Radovick S, Wolfe A. Egr-1 binds the GnRH promoter to mediate the increase in gene expression by insulin. Mol Cell Endocrinol. 270(1-2):64-72, 2007.

    Zanger K, Radovick S, Wondisford, FE. CREB Binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF Box. Mol Cell 7:551-558, 2001.

    Wolfe A, Kim HH, Tobet S, Stafford DEJ, Radovick S. Identification of promoter elements that are essential and sufficient for cell specific expression of the human GnRH gene. Mol Endocrinol 16:435-449, 2002.

    Kim HH, Wolfe A, Tobet S, Radovick S. Identification of a molecular switch directing differential expression of hypothalamic and ovarian GnRH. J Biol Chem 277:5194-5202, 2002.

    Radovick S. Molecular Mechanisms Responsible for Combined Pituitary Hormone Deficiency. J Clin Endocrinol Metab 15:1427-1428, 2002.

    Cohen RN, Cohen LE, Botero D, Yu C, Sagar A, Jurkiewicz M, Radovick S. Enhanced repression by HESX1 as a cause of hypopituitarism and septooptic dysplasia. J Clin Endo Metab 88(10):4832-4839, 2003.

    Wilson TA, Rose SR, Cohen P, Rogol AD, Backeljauw P, Brown R, Hardin DS, Kemp SF, Lawson M, Radovick S, Rosenthal SM, Silverman L, Speiser P. Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr 143(4):415-21, 2003.

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • National Research Science Award, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD. , 1986 - 1989
    • Research Award, Department of Pediatrics, , Case Western Reserve University. , 1986
    • Griff T. Ross Award, Award for Reproductive Endocrinology, , Endocrine Society, 1990
    • Young Investigator Award, Society for Pediatric Research., 1991
    • Center Investigator, Reproductive Endocrine Sciences Center of the Massachusetts General Hospital, 1993 - 2000
    • Knoll Award Finalist, Endocrine Society, 1994
    • Knoll Award Finalist, Endocrine Society, 1998
    • Knoll Award Finalist, Endocrine Society, 2000
    • The Best Doctors in America, Woodward/White, Aiken, SC, 2001

    Memberships

    • American Academy of Pediatrics, 1986
    • Endocrine Society, 1988
    • Lawson Wilkins Pediatric Endocrine Society, 1990
    • Society for Pediatric Research, 1995
    • American Society for Clinical Investigation, 1997
    • American Pediatric Society, 2003
    • Association of American Physicians, 2004

    Professional Activities

    • Chair, Research Council, Pediatric Endocrine Society, 2010
    • Associate Editor, Frontiers in Pituitary Endocrinology, 2010
    • Committee on Pediatric Hospital Rankings, US News and World Report, 2008
    • Member, Genentech Growth Foundation Study Section, 2001
    • Research Council, All Children’s Hospital, Johns Hopkins University School of Medicine, St. Petersburg, FL, 2013
    • Committee on Conflict of Interest, Office of Policy, Johns Hopkins University School of Medicine, 2011
    • Scientific Misconduct Committee, Office of Policy, Johns Hopkins University School of Medicine, 2010
    • Chairman’s Cabinet, Department of Pediatrics, Johns Hopkins University School of Medicine, 2010
    • Appointment and Promotion Committee, Department of Pediatrics, Johns Hopkins University School of Medicine, 2009
    • Intern Selection Committee, Department of Pediatrics, Johns Hopkins University School of Medicine, 2007
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