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Robert Albert Anders, M.D., Ph.D.

Photo of Dr. Robert Albert Anders, M.D., Ph.D.

Associate Professor of Pathology


Expertise: Pathology

Research Interests: Gastrointestinal and Liver Pathology; Liver cancer; Liver cell death and division


The Johns Hopkins Hospital (Main Entrance)
Appointment Phone: 410-502-1033

1800 Orleans St.
Baltimore, MD 21287 map


Dr. Robert Albert Anders is an associate professor of pathology at the Johns Hopkins University School of Medicine. His clinical expertise includes pathology.

Dr. Anders received his M.D. from Mayo Clinic Medical School College of Medicine. He completed his residency in anatomic and clinical pathology and a fellowship in pathology from the University of Chicago Hospitals.

His research interests include gastrointestinal and liver pathology. more


  • Associate Professor of Pathology
  • Assistant Professor of Oncology



  • MD, Mayo Medical School College of Medicine (1998)


  • University of Chicago Hospitals / Anatomic and Clinical Pathology (2002)


  • University of Chicago Hospitals / Pathology (2004)

Board Certifications

  • American Board of Pathology / Anatomic & Clinical Pathology (2002)

Research & Publications

Research Summary

Dr. Anders’ laboratory focuses on the basic processes that lead to liver cell death and division. His team approaches these questions through the use of both experimental models and examination of human tissues. His team is specifically interested in how the Hippo pathway controls the livers response to injury and malignant transformation. They have uncovered this pathway as a key mediator of hepatocyte and cholangiocyte biology.

Selected Publications

View all on Pubmed

  1. Anders, R.A.; Kamel, I.R. Biopsy considerations in the diagnosis of hepatic masses. Clin Gastroenterol Hepatol. 2007 May;5(5):541-544.
  2. Carnell, A.J.; Hale, I.; Denis, S.; Wanders, R.J.; Isaacs, W.B.; Wilson, B.A.; Ferdinandusse, S. Design, synthesis, and in vitro testing of alpha-methylacyl-CoA racemase inhibitors. J Med Chem. 2007 May 31;50(11):2700-2707.
  3. Grosso, J.F.; Kelleher, C.C.; Harris, T.J.; Maris, C.H.; Hipkiss, E.L.; De Marzo, A.; Anders, R.; Netto, G.; Getnet, D.; Bruno, T.C.; Goldberg, M.V.; Pardoll, D.M.; Drake, C.G. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. J Clin Invest. 2007 Nov;117(11):3383-3392.
  4. Sanders, R.P., M. Kocak, P.C. Burger, T.E. Merchant, A. Gajjar, and A. Broniscer. High grade astrocytoma in very young children. Pediatric blood & cancer. 2007;49:888-893.
  5. Xu, Y.; Flies, A.S.; Flies, D.B.; Zhu, G.; Anand, S.; Flies, S.J.; Xu, H.; Anders, R.A.; Hancock, W.W.; Chen, L.; Tamada, K. Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease. Blood. 2007 May 1;109(9):4097-4104.
  6. Collins, S.; Lutz, M.A.; Zarek, P.E.; Anders, R.A.; Kersh, G.J.; Powell, J.D. Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol. 2008 Jan 17;38(2):528-536.
  7. Steinhardt, A.A.; Gayyed, M.F.; Klein, A.P.; Dong, J.; Maitra, A.; Pan, D.; Montgomery, E.A.; Anders, R.A. Expression of Yes-associated protein in common solid tumors. Hum Pathol. 2008 Aug 12.
  8. Singer, A.L.; Locke, J.E.; Stewart, Z.A.; Lonze, B.E.; Hamilton, J.P.; Scudiere, J.R.; Anders, R.A.; Rother, R.P.; Brodsky, R.A.; Cameron, A.M. Successful liver transplantation for Budd-Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab. Liver Transpl. 2009 May;15(5):540-543.
  9. Wada, S.; Yoshimura, K.; Hipkiss, E.L.; Harris, T.J.; Yen, H.R.; Goldberg, M.V.; Grosso, J.F.; Getnet, D.; Demarzo, A.M.; Netto, G.J.; Anders, R.; Pardoll, D.M.; Drake, C.G. Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model. Cancer Res. 2009 May 15;69(10):4309-4318.
  10. Yen, H.R.; Harris, T.J.; Wada, S.; Grosso, J.F.; Getnet, D.; Goldberg, M.V.; Liang, K.L.; Bruno, T.C.; Pyle, K.J.; Chan, S.L.; Anders, R.A.; Trimble, C.L.; Adler, A.J.; Lin, T.Y.; Pardoll, D.M.; Huang, C.T.; Drake, C.G. Tc17 CD8 T cells: functional plasticity and subset diversity. J Immunol. 2009 Dec 1;183(11):7161-7168.
  11. Brahmer, J.R.; Drake, C.G.; Wollner, I.; Powderly, J.D.; Picus, J.; Sharfman, W.H.; Stankevich, E.; Pons, A.; Salay, T.M.; McMiller, T.L.; Gilson, M.M.; Wang, C.; Selby, M.; Taube, J.M.; Anders, R.; Chen, L.; Korman, A.J.; Pardoll, D.M.; Lowy, I.; Topalian, S.L. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010 Jul 1;28(19):3167-3175.
  12. De Jong, M.C.; Hong, S.M.; Augustine, M.M.; Goggins, M.; Wolfgang, C.L.; Hirose, K.; Schulick, R.; Choi, M.; Anders, R.; Pawlik, T.M. Proximal cholangiocarcinoma: Tumor Depth Predicts Outcome. Arch Surg. 2010;In Press.
  13. Karp, J.K.; Akpek, E.K.; Anders, R.A. Autoimmune hepatitis in patients with primary Sjogren''s syndrome: a series of two-hundred and two patients. Int J Clin Exp Pathol. 2010;3(6):582-586.
  14. Tretiakova, M.S.; Shabani-Rad, M.T.; Guggisberg, K.; Hart, J.; Anders, R.A.; Gao, Z.H. Genomic and immunophenotypical differences between hepatocellular carcinoma with and without cirrhosis. Histopathology. 2010 May;56(6):683-693.
  15. Yan, B.C.; Gong, C.; Song, J.; Krausz, T.; Tretiakova, M.; Hyjek, E.; Al-Ahmadie, H.; Alves, V.; Xiao, S.Y.; Anders, R.A.; Hart, J.A. Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol. 2010 Aug;34(8):1147-1154.
  16. Zhang, N.; Bai, H.; David, K.K.; Dong, J.; Zheng, Y.; Cai, J.; Giovannini, M.; Liu, P.; Anders, R.A.; Pan, D. The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell. 2010 Jul 20;19(1):27-38.Lutz ER, Wu AA, Bigelow E, Sharma R, Mo G, Soares K, Solt S, Dorman A, Wamwea A, Yager A, Laheru D, Wolfgang CL, Wang J, Hruban RH, Anders RA, Jaffee EM, Zheng L. "Immunotherapy converts nonimmunogenic pancreatic tumors into immunogenic foci of immune regulation." Cancer Immunol Res. 2014 Jul;2(7):616-31. doi: 10.1158/2326-6066.CIR-14-0027.
  17. Kim Y, Ejaz A, Tayal A, Spolverato G, Bridges JF, Anders RA, Pawlik TM. "Temporal trends in population-based death rates associated with chronic liver disease and liver cancer in the United States over the last 30 years." Cancer. 2014 Jun 10. doi: 10.1002/cncr.28843.
  18. Zhu AX, Borger DR, Kim Y, Cosgrove D, Ejaz A, Alexandrescu S, Groeschl RT, Deshpande V, Lindberg JM, Ferrone C, Sempoux C, Yau T, Poon R, Popescu I, Bauer TW, Gamblin TC, Gigot JF, Anders RA, Pawlik TM. "Genomic Profiling of Intrahepatic Cholangiocarcinoma: Refining Prognosis and Identifying Therapeutic Targets." Ann Surg Oncol. 2014 Jun 3.
  19. Gurda GT, Zhu Q, Bai H, Pan D, Schwarz KB, Anders RA. "The use of Yes-associated protein expression in the diagnosis of persistent neonatal cholestatic liver disease." Hum Pathol. 2014 May;45(5):1057-64. doi: 10.1016/j.humpath.2014.01.002. Epub 2014 Jan 23.
  20. Taube JM, Klein AP, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL, Anders RA. "Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy." Clin Cancer Res. 2014 Apr 8.
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