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Janis Marie Taube, M.D., M.Sc.

Photo of Dr. Janis Marie Taube, M.D., M.Sc.

Director, Division of Dermatopathology

Associate Professor of Dermatology

Female

Expertise: Dermatopathology, Pathology

Research Interests: Prognostic and predictive value of the immunoarchitecture of melanoma; Merkel cell carcinoma; and other cutaneous neoplasms ...read more

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street
Sheikh Zayed Tower Suite 907
Baltimore, MD 21287 map
Phone: 410-955-3484
Fax: 410-955-2445

Background

Dr. Janis Taube is an Associate Professor of dermatology and pathology at the Johns Hopkins University School of Medicine. Her area of clinical expertise is dermatopathology. Dr. Taube serves as the Director of the Division of Dermatopathology and as the Assistant Director of the Dermatoimmunology Laboratory at the School of Medicine.

Dr. Taube received her undergraduate degree in engineering from Duke University. She earned her M.D. from Tulane University and her M.Sc. in molecular medicine from University College London. She completed her residency in pathology at Johns Hopkins where she also served as the chief resident, before undertaking a dermatopathology fellowship at Stanford University. In 2009, Dr. Taube returned to Johns Hopkins for her certification in the Melanoma Clinic.

She is one of the lead scientific researchers in the Department of Dermatology at Johns Hopkins. Her research is related to the study of the B7-H1 molecule. Dr. Taube and her team are seeking to identify the signaling mechanisms behind B7-H1 expression.

She is a member of the College of American Pathologists, United States and Canadian Academy of Pathology, American Society of Dermatopathology and Dermatology Foundation.

...read more

Titles

  • Director, Division of Dermatopathology
  • Assistant Director, Dermatoimmunology Laboratory
  • Associate Professor of Dermatology
  • Associate Professor of Oncology
  • Associate Professor of Pathology

Departments / Divisions

Education

Degrees

  • MD, Tulane University School of Medicine (2004)

Residencies

  • Johns Hopkins University School of Medicine / Pathology (2008)

Fellowships

  • Stanford University School of Medicine / Dermatopathology (2009)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (2008)
  • American Board of Pathology / Dermatopathology (2009)

Research & Publications

Research Summary

Dr. Taube is the assistant director of the Dermatoimmunology Laboratory. The lab provides tissue processing for direct immunofluorescence analysis, conducts bullous disease tests, accepts fresh tissue samples and provides blood/serum processing for indirect immunofluorescence analysis.

Selected Publications

Taube JM, Anders RA, Xu H, Sharma R, Klien A, Topalian SL, Chen L. Colocalization of inflammatory response with B7-H1 [PD-L1] expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012;4:127ra37.

Taube JM, Klein A, Brahmer JR, Xu H, Pan X, Kim JH, Chen L, Pardoll DM, Topalian SL, Anders RA. Association of PD-1, PD-Ls and features of the tumor immune microenvironment with anti-PD-1 therapeutic response. Clin Can Res. 2014;20(19):5064-74.

Lipson EJ, Vincent JG, Loyo M, Kagohara LT, Luber BS, Wang H, Xu H, Nayar SK, Wang TS, Sidransky D, Anders RA, Topalian SL, Taube JM. PD-L1 expression in the Merkel cell carcinoma microenvironment: Association with inflammation, Merkel cell polyomavirus and overall survival. Cancer Immunol Res. 2013; 19(2):462-8.

Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, and Topalian SL. Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade. Clin Can Res 2015;21(17):3969-76.

Rodic N, Anders RA, Eshleman JR, Lin MT, Xu H, Kim JH, Beirl K, Chen S, Luber BS, Wang H, Topalian SL, Pardoll DM, Taube JM. PD-L1 expression in melanocytic lesions does not correlate with the BRAF V600E mutation. Cancer Immunol Res. 2015;3(2):110-5.

Activities & Honors

Memberships

  • American Society of Dermatopathology
  • College of American Pathologists
  • Dermatology Foundation
  • United States and Canadian Academy of Pathology
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