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Kathleen Helen Burns, MD PhD

Associate Professor of Pathology

See Research on Pubmed | See Research on Google Scholar

Female
Appointment Phone

410-502-7214

Main Location

Johns Hopkins Bayview Medical Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Associate Professor of Pathology
  • Associate Professor of Oncology

Centers & Institutes

  • High Throughput Biology Center
  • McKusick-Nathans Institute of Genetic Medicine
  • Sidney Kimmel Comprehensive Cancer Center

Expertise

Hematologic Pathology, Hematopathology, Leukemia, Lymphoma, Pathology

Research Interests

Roles of transposable elements and other mobile DNAs in human disease

Biography

Dr. Kathleen Burns is an associate professor of pathology and oncology at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include hematologic pathology, hematopathology, leukemia, lymphoma and pathology. She is a member of the Institute of Genetic Medicine's predoctoral training program in human genetics.

Dr. Burns received her undergraduate degree in chemistry from the University of Southern Mississippi. She earned her M.D. and Ph.D. from Baylor College of Medicine. She completed her residency at the Johns Hopkins University School of Medicine and performed a fellowship in pathology at Johns Hopkins.

Her research interests include the roles of transposable elements and other mobile DNAs in human disease.

Dr. Burns received a Career Award for Medical Scientists (CAMS) from the Burroughs Wellcome Fund in 2008.

Languages

  • English

Memberships

  • United States and Canadian Academy of Pathology,
  • American Society of Clinical Pathology
  • American Society of Hematology

Additional Resources

Additional Resources +
  • Education +

    Training

    • Baylor College of Medicine (Houston TX ) (2004)

    Residencies

    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD ) (2007)

    Fellowships

    • Johns Hopkins University School of Medicine / Pathology (Baltimore MD ) (2008)

    Certifications

    • Clinical Pathology, American Board of Pathology (2008)
    • Hematology, American Board of Pathology - Pathology (2008)
  • Research & Publications +

    Research Summary

    Dr. Burns is a physician-scientist and practicing pathologist who studies roles of transposable elements and other mobile DNAs in human disease, with an emphasis on cancer development. There is compelling evidence that these poorly understood sequences can contribute to genomic instability and mRNA transcript alterations in the context of neoplasia; her research team believes inherited insertions also may create predispositions to disease.

    Projects in her lab include:

    1. The development of one-sided PCR based assays to map mobile DNAs in the human genome;
    2. Finding evidence for somatic insertions of mobilized DNAs in cancers, and exploring potential clinical markers and mechanisms underlying this instability;
    3. Describing common inherited transposon insertion polymorphisms in cancer patients and assessing whether these structural variations contribute to cancer susceptibility or tumor progression.

    Selected Publications View all on PubMed

    1. Mobile interspersed repeats are major structural variants in the human genome. Huang CR, Schneider AM, Lu Y, Niranjan T, Shen P, Robinson MA, Steranka JP, Valle D, Civin CI, Wang T, Wheelan SJ, Ji H, Boeke JD, Burns KH. Cell. 2010 Jun 25;141(7):1171-82.
    2. Roles of retrotransposons in benign and malignant hematologic disease. Schneider AM, Duffield AS, Symer DE, Burns KH. Cellscience. 2009 Oct 27;6(2):121-145
    3. Great exaptations. Burns KH, Boeke JD. J Biol. 2008;7(2):5.
    4. A descent into the nuage: the maelstrom of transposon control. O''Donnell KA, Burns KH, Boeke JD. Dev Cell. 2008 Aug;15(2):179-81.
    5. GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk MM. PLoS Genet. 2009 Sep;5(9):e1000635.
    6. Burns, F.J.; Samet, J.M.; Rossman, T.G.; Zhang, R.; Wu, F.; Uddin, A.N.; Shore, R.E. Radiation Carcinogenesis: Mechanisms of Induction. In: Rom, R.W., editor. 4th ed, Environmental and Occupational Medicine. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2007. p. 1262-1276.
    7. Hanes, J.W.; Burns, K.E.; Hilmey, D.G.; Chatterjee, A.; Dorrestein, P.C.; Begley, T.P. Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. J Am Chem Soc. 2008 Mar 12;130(10):3043-3052.
    8. Sandford, G.R.; Schumacher, U.; Ettinger, J.; Brune, W.; Hayward, G.S.; Burns, W.H.; Voigt, S. Deletion of the rat cytomegalovirus immediate early 1 gene results in a virus capable of establishing latency but with lower levels of acute virus replication and latency that compromise reactivation efficiency. J Gen Virol. 2009 Nov 18.
    9. Wheless, L.; Ruczinski, I.; Alani, R.M.; Clipp, S.; Hoffman-Bolton, J.; Jorgensen, T.J.; Liegeois, N.J.; Strickland, P.T.; Alberg, A.J. The association between skin characteristics and skin cancer prevention behaviors. Cancer Epidemiol Biomarkers Prev. 2009 Oct;18(10):2613-2619.
    10. Burns, T.F.; Rudin, C.M. Lung cancer in 'never-smokers': beyond EGFR mutations and EGFR-TK inhibitors. Oncology (Williston Park). 2010 Jan;24(1):48-49.
    11. Burns, W.R.; Zeiger, M.A. Differentiated thyroid cancer. Semin Oncol. 2010 Dec;37(6):557-566.
    12. Huang, C.R.; Schneider, A.M.; Lu, Y.; Niranjan, T.; Shen, P.; Robinson, M.A.; Steranka, J.P.; Valle, D.; Civin, C.I.; Wang, T.; Wheelan, S.J.; Ji, H.; Boeke, J.D.; Burns, K.H. Mobile interspersed repeats are major structural variants in the human genome. Cell. 2010 Jun 25;141(7):1171-1182.
    13. O'Donnell, K.A.; Burns, K.H. Mobilizing diversity: transposable element insertions in genetic variation and disease. Mob DNA. 2010;1(1):21.
    14. Huang CR, Burns KH, Boeke JD. "Active transposition in genomes." Annu Rev Genet. 2012;46:651-75. doi: 10.1146/annurev-genet-110711-155616. Review.
    15. Burns KH, Boeke JD. "Human transposon tectonics." Cell. 2012 May 11;149(4):740-52. doi: 10.1016/j.cell.2012.04.019. Review.
    16. Huang CR, Schneider AM, Lu Y, Niranjan T, Shen P, Robinson MA, Steranka JP, Valle D, Civin CI, Wang T, Wheelan SJ, Ji H, Boeke JD, Burns KH. "Mobile interspersed repeats are major structural variants in the human genome." Cell. 2010 Jun 25;141(7):1171-82. doi: 10.1016/j.cell.2010.05.026.
    17. Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk MM. "GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline." PLoS Genet. 2009 Sep;5(9):e1000635. doi: 10.1371/journal.pgen.1000635. Epub 2009 Sep 4. Erratum in: PLoS Genet. 2009 Dec;5(12). doi: 10.1371/annotation/20bf08d1-07e9-451e-b079-166832ebe158.
    18. O'Donnell KA, Burns KH, Boeke JD. "A descent into the nuage: the maelstrom of transposon control." Dev Cell. 2008 Aug;15(2):179-81. doi: 10.1016/j.devcel.2008.07.016.
  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Pathobiology Graduate Program

  • Activities & Honors +

    Honors

    • Career Award for Medical Scientists (CAMS), Burroughs Wellcome Fund, 2008
    • 1993 National Merit Scholar
    • 1995 National Barry M. Goldwater Scholarship
    • 1997 Phi Kappa Phi National Graduate Scholarship
    • 1997 Alpha Lambda Delta National Graduate Scholarship
    • 2001 National Eye Institute Research T32 Fellowship Award
    • 2002 Society for the Study of Reproduction, Lalor Foundation Travel Award
    • 2003 Baylor College of Medicine M.S.T.P. Research Publication Award
    • 2004 Baylor College of Medicine Department of Pathology Outstanding Graduate Student
    • 2008 Johns Hopkins University, Department of Pathology, 10thAnnual Young Investigators’ Day Award for Excellence in Basic Research
    • 2008 Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center Fellow Research Day Honorable Mention for Basic Research
    • 2014 University of Arkansas for Medical Sciences, M.S.T.P. Student’s Choice Award and Lectureship

    Professional Activities

    • Department of Pathology Residency Selection Committee, Johns Hopkins Univeristy School of Medicine
    • Department of Pathology Research Advisory Committee, Johns Hopkins Univeristy School of Medicine
    • Department of Pathology Pathobiology Graduate Program Executive Committee, Johns Hopkins Univeristy School of Medicine
    • Research Council member and co-­‐Chair of the Discovery Fund subcommittee, Johns Hopkins Univeristy School of Medicine

    Ad hoc reviewer for:

    • Science
    • Nucleic Acids Research
    • Genome Biology
    • Genome Research
    • Human Mutation
    • Current Molecular Medicine
    • Clinical Genetics
    • Future Medicine
    • Tissue Antigens
  • Videos & Media +

    Lectures and Presentations

    • 1/14/15 Cancer Biology and The "Junk" Genome; Partnering for Discovery Seminar; Turner Concourse, Johns Hopkins University School of Medicine
    • 4/15/14 New Perspectives on Junk DNA; Keynote speaker, 5th Annual MD/PhD Student''s Choice Award Recipient; Medical Scientist Training Program, University of Arkansas for Medical Sciences
    • 4/11/14 Five Steps Further: A Guide to Research; Keynote speaker, Undergraduate Research Symposium; College of Arts and Letters and the Center for Undergraduate Research, University of Southern Mississippi
    • 4/1/13 Mapping and Functional Analysis of Transposable Element Insertions; Transposable Elements in the Brain and Other Tissues: Prevalence and Function Banbury Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
    • 7/31/12 Profiling L1 and Alu Retrotransposon Polymorphism in Normal Samples and Cancer Cell Panels; A New Horizon of Retroposon Research, 63rd Annual Fujihara Seminar Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Kyoto, Japan.
    • 5/14/12 Repetitive DNA, DNA, DNA; PCTB 517, Center for Computational Genomics Seminar, Johns Hopkins Universiry School of Medicine
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-502-7214
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-502-7214
    Location Map
    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-502-7214
    Location Map

    Department/Division

    • Pathology

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