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School of Medicine
Murray Ramanathan, Jr, M.D.
Murugappan Ramanathan, Jr, M.D.
Medical Director, Johns Hopkins Otolaryngology-Head and Neck Surgery in Bethesda
Assistant Professor of Otolaryngology - Head and Neck Surgery
Specializes in: Adults (18+ years)
Languages: English, Tamil
Expertise: Cerebrospinal Fluid (CSF) Leaks, Chronic Sinusitis with Polyps, Endoscopic Frontal Sinus Surgery, Nasal Obstruction, Nasal Polyps, Otolaryngology, Paranasal Sinus Tumors, Revision Endoscopic Sinus Surgery, Revision Frontal Sinus Surgery, Sinus Problems, Sinusitis, Sinusitis and Nasal Polyposis, Skull Base Tumors ...read more
Research Interests: Molecular and immunologic (innate and adaptive) mechanisms underlying the pathogenesis of chronic rhinosinusitis with nasal polyps; Role of Allergy and Environmental pollutants in propagating sinonasal inflammation ...read more
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Johns Hopkins Otolaryngology - Head and Neck Surgery
Appointment Phone: 301-896-3330
6420 Rockledge Drive
Bethesda, MD 20817 map
Dr. Ramanathan was born and raised in Dallas, TX, and received a bachelor's degree in Molecular Biophysics and Biochemistry from Yale University. He subsequently received his M.D. from The University of Texas Medical Branch at Galveston where he graduated with highest honors and completed his internship in general surgery and residency in otolaryngology-head and neck surgery at Johns Hopkins. During residency, Dr. Ramanathan focused on researching the pathogenesis of chronic rhinosinusitis which resulted in numerous presentations and publications at national meetings. Upon completion of his residency, he received additional fellowship training in advanced endoscopic sinus and minimally invasive skull base surgery at Johns Hopkins.
Dr. Ramanathan evaluates patients primarily at the Johns Hopkins Healthcare and Surgery Center in Bethesda, Maryland, as a part of the greater Washington D.C. region practice of Johns Hopkins Otolaryngology-Head and Neck Surgery. If indicated, he can also perform surgery at Suburban Hospital in Bethesda.
His clinical interests include chronic rhinosinusitis with nasal polyps/chronic frontal sinusitis, surgery for nasolacrimal duct obstruction/thyroid eye disease, and endoscopic approaches for resection of sinonasal and anterior skull base tumors. As an active clinician-scientist, Dr. Ramanathan also has a mentored career development award funded by the National Institutes of Health to study the role of environmental pollutants in propagating chronic sinusitis and allergic rhinitis with collaborators at Johns Hopkins School of Medicine and the Johns Hopkins Bloomberg School of Public Health.
- Medical Director, Johns Hopkins Otolaryngology-Head and Neck Surgery in Bethesda
- Assistant Professor of Otolaryngology - Head and Neck Surgery
Departments / Divisions
- Otolaryngology - Head and Neck Surgery - Rhinology and Sinus
- Surgery at Suburban Hospital
- MD, University of Texas Medical Branch School of Medicine (2004)
- Johns Hopkins University School of Medicine / Otolaryngology (2009)
- American Board of Otolaryngology / Otolaryngology (2010)
Research & Publications
Selected PublicationsMurugappan Ramanathan, Jr., Won-Kyung Lee, and Andrew P. Lane. Increased Expression of Acidic Mammalian Chitinase (AMCase) is Associated With Chronic Rhinosinusitis with Nasal Polyps. Am J. Rhinol. 2006 May-Jun; 20(3):330-335
Murugappan Ramanathan, Jr., Ernst W. Spannhake, and Andrew P. Lane. Decreased Expression of Interleukin 22 Receptor is Associated With Chronic Rhinosinusitis with Nasal Polyps. Laryngoscope 2007 Oct; 117(10):1839-43
Murugappan Ramanathan, Jr. and Andrew P. Lane. A Comparison of Experimental Methods in Molecular Chronic Rhinosinusitis Research. Am J. Rhinol. 2007 May-Jun; 21(3): 373-7
Murugappan Ramanathan, Jr., Won K. Lee, Marc G. Dubin, Sandra Lin, Ernst W. Spannhake, and Andrew P. Lane. Sinonasal Epithelial Cell Expression of Toll-Like Receptor 9 is Decreased in Chronic Rhinosinusitis with Nasal Polyps. Am. J. Rhinol 2007 Jan-Feb; 21(1): 110-116
Murugappan Ramanathan, Jr. and Andrew P. Lane. Innate Immunity of the Sinonasal Cavity and its Role in Chronic Rhinosinusitis. Otolaryngol Head Neck Surg. 2007 Mar; 136(3):348-56. Review.
Won K. Lee, Murugappan Ramanathan, Jr., Ernst. W. Spannhake, and Andrew P. Lane. The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and HBD-2 by sinonasal epithelial cells. Am. J. Rhinol. 2007 Nov-Dec; 21 (6) 658-663
Murugappan Ramanathan, Jr., Won K. Lee, Ernst W. Spannhake, and Andrew P. Lane. Th2 Cytokines Associated with Chronic Rhinosinusitis with Polyps Down-Regulate the Anti-Microbial Immune Function of Human Sinonasal Epithelial Cells. Am. J. Rhinol. 2008 Mar-Apr; 22(2) 115-21
Ashley Lalaker, Louis Nkrumah, Won K. Lee, Murugappan Ramanathan, Jr., and Andrew P. Lane. Dust Mite Antigen Modulates Innate Immune Gene Expression By Human Sinonasal Epithelial Cells. Am. J. Rhinol Allergy 2009 Jan-Feb; 23(1)8-14
Douglas Reh, Yadong Wang, Leda Pawliuk, Murugappan Ramanathan, Jr., and Andrew P. Lane. Treatment-recalcitrant chronic rhinosinusitis with polyps is associated with altered epithelial cell expression of interleukin-33. Am J. Rhinol Allergy 2010 Mar;24(2):105-9.
Murugappan Ramanathan, Jr., Justin Turner, and Andrew P. Lane. Technological Advances in Rhinologic Basic Science Research. Otolaryngology Clinics 2009. Oct; 42(5):867-81
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