Dr. Milstone’s research focuses on the prevention of hospital- acquired infections (HAIs) and the emergence of antibiotic resistance in children.
His work is helping to define the prevalence and transmission of multi-drug-resistant bacteria in hospitalized children and to identify interventions to reduce their spread and prevent HAIs.
Dr. Milstone is investigating topics that include:
- Interventions to reduce the spread of multi-drug-resistant bacteria and prevent HAIs in hospitalized children
- Safety and efficacy of chlorhexidine antisepsis in preventing HAIs in children
- Epidemiology and prevention of central line-associated bloodstream infections
- Whether rapid diagnostic tests can enable early access to therapy and reduce transmission of respiratory viruses among hospitalized children
Some of Dr. Milstone’s recent work has focused on understanding the mechanisms of bacterial drug-resistance and on developing strategies to prevent hospital-acquired infections among critically ill children. His research findings have fueled innovative risk-reduction protocols—including the use of daily antiseptic baths to reduce the risk of bloodstream infections in critically ill children—and led to their widespread practice in pediatric hospitals across the U.S.
Milstone AM, Reich NG, Advani S, Yuan G, Bryant K, Coffin SE, Huskins WC, Livingston R, Saiman L, Smith RB, Song X. "Catheter Dwell Time and CLABSIs in Neonates with PICCs: A Multicenter Cohort Study." Pediatrics 2013 Dec;132(6):e1609-15. Epub 2013 Nov 11
Popoola VO, Carroll KC, Ross T, Reich NG, Perl TM, Milstone AM. "Impact of Colonization Pressure and Strain Type on MRSA Transmission in Children." Clin Infect Dis 2013 Nov;57(10):1458-60. Epub 2013 Aug 13.
Jumani K, Advani S, Gosey L, Reich NG, Milstone AM. "Risk Factors for Peripherally Inserted Central Venous Catheter Complications in Children." JAMA Pediatr. 2013 May 1;167(5):429-35. Epub 2013 Mar 18
Milstone AM, Elward A, Song X, Zerr DM, Orscheln R, Speck K, Obeng D, Reich NG, Coffin SE, Perl TM. "Daily Chlorhexidine Bathing to Reduce Bacteraemia in Critically Ill Children: a Multicentre, Cluster-Randomised, Crossover Trial." Lancet. 2013 Mar 30;381(9872):1099-106. Epub 2013 Jan 28.
Milstone AM, Goldner BW, Ross R, Shepard JW, Carroll KC, Perl TM. "Methicillin- Resistant Staphylococcus aureus Colonization and Risk of Subsequent Infection in Critically Ill Children: Importance of Prevention Nosocomial Transmission." Clin Infect Dis. 2011 Nov;53(9):853-9. Epub 2011 Aug 29.