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Thomas Grader-Beck, M.D., Ph.D.

Photo of Dr. Thomas Grader-Beck, M.D., Ph.D.

Assistant Professor of Medicine

Male

Languages: English, French, German

Expertise: Rheumatology, Sjogren's Syndrome, Systemic Lupus Erythematosus

Research Interests: Pathogenesis of systemic autoimmune diseases, systemic lupus erythematosus and Sjogren''s

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Locations

Johns Hopkins Bayview Medical Center
Appointment Phone: 443-997-1552

Sjogrens Center
301 Mason Lord Drive
Baltimore, MD 21224 map
Phone: 410-550-1887

Johns Hopkins Bayview Medical Center
Appointment Phone: 443-997-1552

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-8089
Fax: 410-550-5601

Background

Dr. Grader-Beck is an Assistant Professor of Medicine in the Rheumatology Division. 

Dr. Grader-Beck’s clinical interests include systemic lupus erythematosus and Sjögren’s syndrome, with emphasis on complex patients that are difficult to treat, as well as patients with vaginal sicca.

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Titles

  • Assistant Professor of Medicine

Education

Degrees

  • MD, Heidelberg University School of Medicine (1997)

Residencies

  • University of Massachusetts Medical Center / Internal Medicine (2003)

Fellowships

  • Dana-Farber Cancer Institute (2000)
  • Johns Hopkins University School of Medicine / Rheumatology (2006)

Board Certifications

  • American Board of Internal Medicine / Internal Medicine (2003, 2017)
  • American Board of Internal Medicine / Rheumatology (2005, 2017)

Research & Publications

Research Summary

His research interests include systemic lupus erythematosus and Sjögren’s syndrome. The pathogenesis of SLE and Sjogren’s syndrome, two closely related and common systemic autoimmune diseases, remains unknown. Antibodies that target self-molecules (autoantibodies) are thought to play an important role in the disease process. Dr. Grader-Beck’s laboratory is investigating mechanisms that may render self-structures immunogenic and hypothesizes that specific posttranslational modifications of antigens that may occur during infections or malignant transformation lead to expression of neoepitopes that propagate autoimmunity in the right setting. By combining studies using a variety of mouse strains, specific gene-deficient mice as well as human biological specimens, Dr. Grader-Beck’s team is taking a translational approach to answer these questions.

Selected Publications

Mathews PM, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer AN, Akpek
EK. Ocular Complications of Primary Sjögren Syndrome in Men. Am J Ophthalmol.
2015 Sep;160(3):447-452.e1. doi: 10.1016/j.ajo.2015.06.004. Epub 2015 Jun 17.
PubMed PMID: 26093285.

Akpek EK, Mathews P, Hahn S, Hessen M, Kim J, Grader-Beck T, Birnbaum J, Baer
AN. Ocular and systemic morbidity in a longitudinal cohort of Sjögren's syndrome.
Ophthalmology. 2015 Jan;122(1):56-61. doi: 10.1016/j.ophtha.2014.07.026. Epub
2014 Aug 30. PubMed PMID: 25178806.

Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. Antibodies
recognising sulfated carbohydrates are prevalent in systemic sclerosis and
associated with pulmonary vascular disease. Ann Rheum Dis. 2011
Dec;70(12):2218-24. doi: 10.1136/ard.2011.153130. Epub 2011 Aug 26. PubMed PMID:
21873333; PubMed Central PMCID: PMC3409247.

O'Shaughnessy MJ, Chen ZM, Gramaglia I, Taylor PA, Panoskaltsis-Mortari A,
Vogtenhuber C, Palmer E, Grader-Beck T, Boussiotis VA, Blazar BR. Elevation of
intracellular cyclic AMP in alloreactive CD4(+) T Cells induces
alloantigen-specific tolerance that can prevent GVHD lethality in vivo. Biol
Blood Marrow Transplant. 2007 May;13(5):530-42. PubMed PMID: 17448912.

Park JK, Subhawong AP, Ziminski CM, Grader-Beck T. Dermatomyositis as the
initial presentation of a large anaplastic T-cell lymphoma. J Clin Oncol. 2011
May 1;29(13):e378-80. doi: 10.1200/JCO.2010.33.2528. Epub 2011 Feb 22. PubMed
PMID: 21343565.

Grader-Beck T, Casciola-Rosen L, Lang TJ, Puliaev R, Rosen A, Via CS.
Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose)
polymerase 1 in a murine model of lupus. J Immunol. 2007 Jan 1;178(1):95-102.
PubMed PMID: 17182544.

Grader-Beck T, Wigley FM. Raynaud's phenomenon in mixed connective tissue
disease. Rheum Dis Clin North Am. 2005 Aug;31(3):465-81, vi. Review. PubMed PMID:
16084319.

Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA. cAMP inhibits
both Ras and Rap1 activation in primary human T lymphocytes, but only Ras
inhibition correlates with blockade of cell cycle progression. Blood. 2003 Feb
1;101(3):998-1006. Epub 2002 Sep 19. PubMed PMID: 12393539

Appleman LJ, Tzachanis D, Grader-Beck T, van Puijenbroek AA, Boussiotis VA.
Helper T cell anergy: from biochemistry to cancer pathophysiology and
therapeutics. J Mol Med (Berl). 2001;78(12):673-83. Review. PubMed PMID:
11434720.

Appleman LJ, Tzachanis D, Grader-Beck T, Van Puijenbroek AA, Boussiotis VA.
Induction of immunologic tolerance for allogeneic hematopoietic cell
transplantation. Leuk Lymphoma. 2002 Jun;43(6):1159-67. Review. PubMed PMID:
12152983

Activities & Honors

Memberships

  • American College of Physicians, 2006
  • American College Of Rheumatology, 2003
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