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Ben Ho Park, M.D., Ph.D.

Professor of Oncology


Appointment Phone


Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

Appointment Phone: 410-955-8964

401 N. Broadway
Baltimore, MD 21231 map
Phone: 410-502-7399
Fax: 410-614-8397


Breast Cancer, Medical Oncology

Research Interests

breast cancer

    Additional Information

  • Education +


    • University of Pennsylvania School of Medicine / MD (1995)


    • University of Pennsylvania School of Medicine / Internal Medicine (1998)


    • American Board of Internal Medicine / Medical Oncology (2002)
  • Research & Publications +

    Clinical Trial Keywords: breast cancer

    Selected Publications View all on PubMed

    Abukhdeir, A.M.; Blair, B.G.; Brenner, K.; Karakas, B.; Konishi, H.; Lim, J.; Sahasranaman, V.; Huang, Y.; Keen, J.; Davidson, N.; Vitolo, M.I.; Bachman, K.E.; Park, B.H. Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells. Breast Cancer Res Treat. 2006 Sep;99(1):23-33.

    Huang, Y.; Keen, J.C.; Pledgie, A.; Marton, L.J.; Zhu, T.; Sukumar, S.; Park, B.H.; Blair, B.; Brenner, K.; Casero, R.A., Jr.; Davidson, N.E. Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells. J Biol Chem. 2006 Jul 14;281(28):19055-19063.
    Karakas, B.; Bachman, K.E.; Park, B.H. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer. 2006 Feb 27;94(4):455-459.

    Karakas, B.; Weeraratna, A.; Abukhdeir, A.; Blair, B.G.; Konishi, H.; Arena, S.; Becker, K.; Wood, W., 3rd; Argani, P.; De Marzo, A.M.; Bachman, K.E.; Park, B.H. Interleukin-1 alpha mediates the growth proliferative effects of transforming growth factor-beta in p21 null MCF-10A human mammary epithelial cells. Oncogene. 2006 Sep 7;25(40):5561-5569.

    Sjoblom, T.; Jones, S.; Wood, L.D.; Parsons, D.W.; Lin, J.; Barber, T.D.; Mandelker, D.; Leary, R.J.; Ptak, J.; Silliman, N.; Szabo, S.; Buckhaults, P.; Farrell, C.; Meeh, P.; Markowitz, S.D.; Willis, J.; Dawson, D.; Willson, J.K.; Gazdar, A.F.; Hartigan, J.; Wu, L.; Liu, C.; Parmigiani, G.; Park, B.H.; Bachman, K.E.; Papadopoulos, N.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E. The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-274.

    Karakas, B.; Weeraratna, A.; Abukhdeir, A.M.; Konishi, H.; Gustin, J.P.; Vitolo, M.I.; Bachman, K.E.; Park, B.H. p21 gene knock down does not identify genetic effectors seen with gene knock out. Cancer Biol Ther. 2007;6:1025-1030.
    Konishi, H.; Karakas, B.; Abukhdeir, A.M.; Lauring, J.; Gustin, J.P.; Garay, J.P.; Konishi, Y.; Gallmeier, E.; Bachman, K.E.; Park, B.H. Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation. Cancer Res. 2007 Sep 15;67(18):8460-8467.

    Konishi, H.; Lauring, J.; Garay, J.P.; Karakas, B.; Abukhdeir, A.M.; Gustin, J.P.; Konishi, Y.; Park, B.H. A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting. Nat Protoc. 2007;2(11):2865-2874.

    Park, B.H.; Davidson, N.E. PI3 kinase activation and response to Trastuzumab Therapy: what''s neu with herceptin resistance? Cancer Cell. 2007 Oct;12(4):297-299.

    Weiss, M.B.; Vitolo, M.I.; Baerenfaller, K.; Marra, G.; Park, B.H.; Bachman, K.E. Persistent mismatch repair deficiency following targeted correction of hMLH1. Cancer Gene Ther. 2007 Jan;14(1):98-104.

    Wood, L.D.; Parsons, D.W.; Jones, S.; Lin, J.; Sjoblom, T.; Leary, R.J.; Shen, D.; Boca, S.M.; Barber, T.; Ptak, J.; Silliman, N.; Szabo, S.; Dezso, Z.; Ustyanksky, V.; Nikolskaya, T.; Nikolsky, Y.; Karchin, R.; Wilson, P.A.; Kaminker, J.S.; Zhang, Z.; Croshaw, R.; Willis, J.; Dawson, D.; Shipitsin, M.; Willson, J.K.; Sukumar, S.; Polyak, K.; Park, B.H.; Pethiyagoda, C.L.; Pant, P.V.; Ballinger, D.G.; Sparks, A.B.; Hartigan, J.; Smith, D.R.; Suh, E.; Papadopoulos, N.; Buckhaults, P.; Markowitz, S.D.; Parmigiani, G.; Kinzler, K.W.; Velculescu, V.E.; Vogelstein, B. The genomic landscapes of human breast and colorectal cancers. Science. 2007 Nov 16;318(5853):1108-1113.

    Abukhdeir, A.M.; Vitolo, M.I.; Argani, P.; De Marzo, A.M.; Karakas, B.; Konishi, H.; Gustin, J.P.; Lauring, J.; Garay, J.P.; Pendleton, C.; Konishi, Y.; Blair, B.G.; Brenner, K.; Garrett-Mayer, E.; Carraway, H.; Bachman, K.E.; Park, B.H. Tamoxifen-stimulated growth of breast cancer due to p21 loss. Proc Natl Acad Sci U S A. 2008 Jan 8;105(1):288-293.

    Chaerkady, R.; Harsha, H.C.; Nalli, A.; Gucek, M.;
    Vivekanandan, P.; Akhtar, J.; Cole, R.N.; Simmers, J.; Schulick, R.D.; Singh, S.; Torbenson, M.; Pandey, A.; Thuluvath, P.J. A quantitative proteomic approach for identification of potential biomarkers in hepatocellular carcinoma. J Proteome Res. 2008 Oct;7(10):4289-4298.

    Lauring, J.; Abukhdeir, A.M.; Konishi, H.; Garay, J.P.; Gustin, J.P.; Wang, Q.; Arceci, R.J.; Matsui, W.; Park, B.H. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. Blood. 2008 Jan 15;111(2):856-864.

    Leary, R.J.; Lin, J.C.; Cummins, J.; Boca, S.; Wood, L.D.; Parsons, D.W.; Jones, S.; Sjoblom, T.; Park, B.H.; Parsons, R.; Willis, J.; Dawson, D.; Willson, J.K.; Nikolskaya, T.; Nikolsky, Y.; Kopelovich, L.; Papadopoulos, N.; Pennacchio, L.A.; Wang, T.L.; Markowitz, S.D.; Parmigiani, G.; Kinzler, K.W.; Vogelstein, B.; Velculescu, V.E. Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16224-16229.

    Woo, J.; Chae, Y.K.; Jang, S.J.; Kim, M.S.; Baek, J.H.; Park, J.C.; Trink, B.; Ratovitski, E.; Lee, T.; Park, B.; Park, M.; Kang, J.H.; Soria, J.C.; Lee, J.; Califano, J.; Sidransky, D.; Moon, C. Membrane trafficking of AQP5 and cAMP dependent phosphorylation in bronchial epithelium. Biochem Biophys Res Commun. 2008 Feb 8;366(2):321-327.

    Woo, J.; Lee, J.; Chae, Y.K.; Kim, M.S.; Baek, J.H.; Park, J.C.; Park, M.J.; Smith, I.M.; Trink, B.; Ratovitski, E.; Lee, T.; Park, B.; Jang, S.J.; Soria, J.C.; Califano, J.A.; Sidransky, D.; Moon, C. Overexpression of AQP5, a putative oncogene, promotes cell growth and transformation. Cancer Lett. 2008 Jun 8;264(1):54-62.

    Chaerkady, R.; Kerr, C.L.; Marimuthu, A.; Kelkar, D.S.; Kashyap, M.K.; Gucek, M.; Gearhart, J.D.; Pandey, A. Temporal analysis of neural differentiation using quantitative proteomics. J Proteome Res. 2009 Mar;8(3):1315-1326.

    Gustin, J.P.; Karakas, B.; Weiss, M.B.; Abukhdeir, A.M.; Lauring, J.; Garay, J.P.; Cosgrove, D.; Tamaki, A.; Konishi, H.; Konishi, Y.; Mohseni, M.; Wang, G.; Rosen, D.M.; Denmeade, S.R.; Higgins, M.J.; Vitolo, M.I.; Bachman, K.E.; Park, B.H. Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2835-2840.

    Hansel, D.E.; Nakayama, M.; Luo, J.; Abukhdeir, A.M.; Park, B.H.; Bieberich, C.J.; Hicks, J.L.; Eisenberger, M.; Nelson, W.G.; Mostwin, J.L.; De Marzo, A.M. Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate. Prostate. 2009 May 1;69(6):603-609.

    Harsha, H.C.; Kandasamy, K.; Ranganathan, P.; Rani, S.; Ramabadran, S.; Gollapudi, S.; Balakrishnan, L.; Dwivedi, S.B.; Telikicherla, D.; Selvan, L.D.; Goel, R.; Mathivanan, S.; Marimuthu, A.; Kashyap, M.; Vizza, R.F.; Mayer, R.J.; Decaprio, J.A.; Srivastava, S.; Hanash, S.M.; Hruban, R.H.; Pandey, A. A compendium of potential biomarkers of pancreatic cancer. PLoS Med. 2009 Apr 7;6(4):e1000046.

    Kandasamy, K.; Keerthikumar, S.; Goel, R.; Mathivanan, S.; Patankar, N.; Shafreen, B.; Renuse, S.; Pawar, H.; Ramachandra, Y.L.; Acharya, P.K.; Ranganathan, P.; Chaerkady, R.; Keshava Prasad, T.S.; Pandey, A. Human Proteinpedia: a unified discovery resource for proteomics research. Nucleic Acids Res. 2009 Jan;37(Database issue):D773-781.

    Kandasamy, K.; Keerthikumar, S.; Raju, R.; Keshava Prasad, T.S.; Ramachandra, Y.L.; Mohan, S.; Pandey, A. PathBuilder-open source software for annotating and developing pathway resources. Bioinformatics. 2009 Nov 1;25(21):2860-2862.

    Kashyap, M.K.; Marimuthu, A.; Kishore, C.J.; Peri, S.; Keerthikumar, S.; Prasad, T.S.; Mahmood, R.; Rao, S.; Ranganathan, P.; Sanjeeviah, R.C.; Vijayakumar, M.; Kumar, K.V.; Montgomery, E.A.; Kumar, R.V.; Pandey, A. Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers. Cancer Biol Ther. 2009 Jan;8(1):36-46.

    Keerthikumar, S.; Bhadra, S.; Kandasamy, K.; Raju, R.; Ramachandra, Y.L.; Bhattacharyya, C.; Imai, K.; Ohara, O.; Mohan, S.; Pandey, A. Prediction of candidate primary immunodeficiency disease genes using a support vector machine learning approach. DNA Res. 2009 Dec;16(6):345-351.

    Keerthikumar, S.; Raju, R.; Kandasamy, K.; Hijikata, A.; Ramabadran, S.; Balakrishnan, L.; Ahmed, M.; Rani, S.; Selvan, L.D.; Somanathan, D.S.; Ray, S.; Bhattacharjee, M.; Gollapudi, S.; Ramachandra, Y.L.; Bhadra, S.; Bhattacharyya, C.; Imai, K.; Nonoyama, S.; Kanegane, H.; Miyawaki, T.; Pandey, A.; Ohara, O.; Mohan, S. RAPID: Resource of Asian Primary Immunodeficiency Diseases. Nucleic Acids Res. 2009 Jan;37(Database issue):D863-867.

    Keshava Prasad, T.S.; Goel, R.; Kandasamy, K.; Keerthikumar, S.; Kumar, S.; Mathivanan, S.; Telikicherla, D.; Raju, R.; Shafreen, B.; Venugopal, A.; Balakrishnan, L.; Marimuthu, A.; Banerjee, S.; Somanathan, D.S.; Sebastian, A.; Rani, S.; Ray, S.; Harrys Kishore, C.J.; Kanth, S.; Ahmed, M.; Kashyap, M.K.; Mohmood, R.; Ramachandra, Y.L.; Krishna, V.; Rahiman, B.A.; Mohan, S.; Ranganathan, P.; Ramabadran, S.; Chaerkady, R.; Pandey, A. Human Protein Reference Database-2009 update. Nucleic Acids Res. 2009 Jan;37(Database issue):D767-772.

    Ranganathan, P.; Harsha, H.C.; Pandey, A. Molecular alterations in exocrine neoplasms of the pancreas. Arch Pathol Lab Med. 2009 Mar;133(3):405-412.

    Vitolo, M.I.; Weiss, M.B.; Szmacinski, M.; Tahir, K.; Waldman, T.; Park, B.H.; Martin, S.S.; Weber, D.J.; Bachman, K.E. Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. Cancer Res. 2009 Nov 1;69(21):8275-8283.

    Colak, D.; Chishti, M.A.; Al-Bakheet, A.B.; Al-Qahtani, A.; Shoukri, M.M.; Goyns, M.H.; Ozand, P.T.; Quackenbush, J.; Park, B.H.; Kaya, N. Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old. Mol Cancer. 2010;9:146.

    Karnan, S.; Mohseni, M.; Konishi, Y.; Tamaki, A.; Hosokawa, Y.; Park, B.H.; Konishi, H. Controversial BRCA1 allelotypes in commonly used breast cancer cell lines. Breast Cancer Res Treat. 2010 Jan;119(1):249-251.

    Lauring, J.; Cosgrove, D.P.; Fontana, S.; Gustin, J.P.; Konishi, H.; Abukhdeir, A.M.; Garay, J.P.; Mohseni, M.; Wang, G.M.; Higgins, M.J.; Gorkin, D.; Reis, M.; Vogelstein, B.; Polyak, K.; Cowherd, M.; Buckhaults, P.J.; Park, B.H. Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. Oncogene. 2010 Apr 22;29(16):2337-2345.

    Lewis, G.H.; Subhawong, A.P.; Nassar, H.; Vang, R.; Illei, P.; Park, B.H.; Argani, P. Relationships between Molecular Subtype of Invasive Breast Carcinoma (IBC) and Expression of Gross Cystic Disease Fluid Protein 15 (GCDFP) and Mammaglobin (MGB). American Journal of Clinical Pathology. 2010;In Press.

    Li, H.; Keeton, A.; Maddox, C.; Rasmussen, L.; Hobrath, J.; White, E.L.; Piazza, G.A.; Kim, J.S.; Vitolo, M.; Park, B.H.; Waldman, T. A High Throughput Screen with Isogenic PTEN+/+ and PTEN -/- Cells Identifies CID1340132 As a novel Compound That Induces Apoptosis in PTEN and PIK3CA Mutant Human Cancer Cells. J Biomol Screen. 2010;In Press.
    Weiss, M.B.; Vitolo, M.I.; Mohseni, M.; Rosen, D.M.; Denmeade, S.R.; Park, B.H.; Weber, D.J.; Bachman, K.E. Deletion of p53 in human mammary epithelial cells causes chromosomal instability and altered therapeutic response. Oncogene. 2010 Aug 19;29(33):4715-4724.

    Higgins, M.J.; Beaver, J.A.; Wong, H.Y.; Gustin, J.P.; Lauring, J.D.; Garay, J.P.; Konishi, H.; Mohseni, M.; Wang, G.M.; Cidado, J.; Jelovac, D.; Cosgrove, D.P.; Tamaki, A.; Abukhdeir, A.M.; Park, B.H. PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells. Cancer Biol Ther. 2011 Feb 1;11(3):35-44.
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