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Photo of Dr. Arun Venkatesan

Arun Venkatesan, MD PhD

Associate Director, Neurology Residency Program
Assistant Professor of Neurology

See Research on Pubmed | See Research on Google Scholar

Male
Appointment Phone

410-614-1522

Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Associate Director, Neurology Residency Program
  • Assistant Professor of Neurology

Centers & Institutes

  • Encephalitis Center
  • Multiple Sclerosis Center

Expertise

Creutzfeldt-Jakob Disease, Encephalitis, Multiple Sclerosis, Neurology, Sarcoidosis, Transverse Myelitis

Research Interests

How to promote repair of the damaged nervous system; Understanding how infection and inflammation damage the nervous system

Biography

Dr. Arun Venkatesan specializes in immunological/inflammatory and infectious diseases that affect the nervous system. Examples include multiple sclerosis, sarcoidosis, transverse myelitis, central nervous system lupus, CNS vasculitis, viral encephalitis, Creutzfeld Jakob Disease, neurologic complications of HIV/AIDS, and paraneoplastic conditions.

Dr. Venkatesans laboratory seeks to: 1) to determine how to protect axons, which are the cables that connect neurons to each other, from inflammatory or infectious damage; and 2) to understand mechanisms by which new neurons can replace damaged cells within the brain and spinal cord. Dr. Venkatesan anticipates that this research will have applications toward a number of diseases, including multiple sclerosis and viral infections of the nervous system.

Dr. Arun Venkatesan received his Ph.D. in microbiology/immunology and his M.D. from the University of California, Los Angeles, followed by an internship in internal medicine at Santa Clara Valley Medical Center. He completed his residency in neurology at The Johns Hopkins Hospital.
Additional Resources +
  • Education +

    Training

    • University of California Los Angeles ( Los Angeles CA) (2002)

    Residencies

    • Johns Hopkins University School of Medicine / Neurology ( Baltimore MD) (2006)

    Certifications

    • American Board of Psychiatry & Neurology / Neurology (2008)
  • Research & Publications +

    Research Summary

    Dr. Venkatesan’s research interests focus on how infectious and immunologic diseases affect the brain. In particular, he is interested in understanding how HIV infection and co-morbid conditions associated with HIV (i.e. substance abuse) affect a process called neurogenesis, the formation of new neurons in the adult brain. Neurogenesis may play an important role in maintaining normal cognitive function, and disruption of neurogenesis by HIV infection, inflammation, or substance abuse may have significant clinical consequences. Through the use of both cell culture and animal model systems, Dr. Venkatesan has found that both HIV and drugs of abuse impair neurogenesis in the hippocampus, an area of the brain important for learning and memory. He is currently focused on developing therapies that restore neurogenesis during infection or inflammation. He is exploring both drug-based approaches and cell-based approaches (transplantation of cells into the brain) with the eventual goal of preventing or reversing cognitive dysfunction in patients with HIV infection, substance abuse, or neuroinflammatory disorders.

    Selected Publications View all on PubMed

    1. Das S, Ott M, Yamane A, Venkatesan A, Gupta S and Dasgupta A. 1998. Inhibition of internal entry site (IRES)-mediated translation by a small yeast RNA: a novel strategy to block hepatitis C virus protein synthesis. Front Biosci 3:1241-52.
    2. Venkatesan A, Das S and Dasgupta A. 1999. Structure and function of a small RNA that selectively inhibits internal ribosome entry site-mediated translation. Nucleic Acids Res 27:562-572.
    3. Venkatesan A and Dasgupta A. 2001. Novel fluorescence-based screen to identify small synthetic internal ribosome entry site elements. Mol Cell Biol 21:2826-2837.
    4. Venkatesan A and Dasgupta A. 2003. Cell cycle regulation of hepatitis C and encephalomyocarditis virus internal ribosome entry site-mediated translation in human embryonic kidney 293 cells. Virus Res 94:85-95.
    5. Dasgupta A, Das S, Izumi R, Venkatesan A, Bharat B. 2004. Targeting internal ribosome entry site (IRES)-mediated translation to block hepatitis C and other RNA viruses. FEMS Microbiol Lett 234:189-199.
    6. Jhaveri R, Kundu P, Shapiro AM, Venkatesan A, Dasgupta A. 2005. Effect of hepatitis C virus core protein on cellular gene expression: specific inhibition of cyclooxygenase 2. J Infect Dis 191:1498-1506.
    7. Venkatesan A, Spalding C, Speedie A, Sinha G, Rumbaugh J. 2005. Pseudomonas aeruginosa infective endocarditis presenting as bacterial meningitis. J Infection 51:199-202.
    8. Venkatesan A, Frucht S. 2006. Movement disorders after resuscitation from cardiac arrest. Neurol Clin 24:123-132.
    9. Steiner J, Haughey N, Wenxue L, Venkatesan A, Anderson C, Reid R, Malpica T, Butterfield A, and Nath A. 2006. Oxidative stress and therapeutic approaches in HIV dementia. Antioxidants and Redox Signaling in Neurodegenerative Disorders 8:2089-100.
    10. Venkatesan A, Selnes O, Wojna V, McArthur JC, and Nath A. 2006. Neuropsychological consequences of HIV and drug abuse. American Journal of Infectious Diseases 2: 90-97.
    11. Venkatesan A, Nath A, Ming G-L, Song H. 2007. Adult hippocampal neurogenesis: regulation by HIV and drugs of abuse. Cell Mol Life Sci.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    2007, Young Investigators Award for Outstanding Research, Society for Neuroimmune Pharmacology
    2006, Jay Slotkin Award, Outstanding Research on Neurologic Disease, Johns Hopkins Neurology
    2006, Guy M. McKhann Award, Excellence in Clinical Teaching, Johns Hopkins Neurology
    2005, Travel Award, Outstanding Potential to be a Future Leader in Academic Neurology, American Neurological Association
    2003, Most Outstanding Intern Award, Santa Clara Valley County Hospital
    2002, Distinguished Service in Medicine and Family Medicine, UCLA
    2001, Indian Medical Association Scholar
    1996, Howard Hughes Medical Institute Research Fellow
    1990-1994, Regents and Chancellors Scholar, U.C. Berkeley, 1990-1994
  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-614-1522
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-614-1522
    Location Map
    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-550-5624
    Location Map

    Department/Division

    • Neurology - Neuroimmunology

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