Lab Website: Roselle Abraham Lab
Rachel Ruckdeschel Smith; Lucio Barile; Hee Cheol Cho; Michelle K. Leppo; Joshua M. Hare; Elisa Messina; Alessandro Giacomello; M Roselle Abraham; Eduardo Marbán. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation. 2007;115(7):896-908.
Circulation Research. 2005;97(2):159-167.
Antonio J. Carrasco; Petras P. Dzeja; Alexey E. Alekseev; Darko Pucar; Leonid V. Zingman; M. Roselle Abraham; Denice Hodgson; Martin Bienengraeber; Michel Puceat; Edwin Janssen; et al. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 2001;98(13):7623-7628.
Zhou L, Solhjoo S, Millare B, Plank G, Abraham MR, Cortassa S, Trayanova N, O’Rourke B. Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol. 2014 Feb 1;7(1):143-51.
Soleimanifard S, Abd-Elmoniem KZ, Sasano T, Agarwal HK, Abraham MR, Abraham TP, Prince JL. Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study. J Cardiovasc Magn Reson. 2012 Dec 13;14(1):85.
Saha S, Corona-Villalobos C, Hurtado-de-Mendoza D, Noureldin R, Zimmerman SL, Bluemke DA, Kamel I, Abraham TP, Abraham MR. Higher Cornell product and QTc on exercise stress testing are correlated with lower T1 times by cardiac MRI in hypertrophic Cardiomyopathy. In review
Rischpler C, Fukushima K, Isoda T, Javadi MS, Dannals RF, Abraham MR, Wahl R, Bengel FM, Higuchi T. Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and Metaiodobenzylguanidine (MIBG) in rat hearts. Eur J Nucl Med Mol Imaging. 2013 Jul;40(7):1077-83.
Reid B, Afzal JM, McCartney AM, Abraham MR, O’Rourke B, Elisseeff JH. Enhanced tissue production through redox control in stem cell-laden hydrogels. Tissue Eng Part A. 2013 Sep;19(17-18):2014-23.
Rahman QA, Tereshchenko LG, Kongkatong M, Abraham TP, Abraham MR, Shatkay H. Identifying hypertrophic cardiomyopathy patients by classifying individual heart beats from 12-lead ECG signals. In review.
Reviews, Book Chapters and Editorials
Wu JC, Abraham MR, Kraitchman D. Perspectives on imaging cardiac stem cell therapy. J of Nuclear Medicine, 2010 May 1:51 Suppl 1:128S-136S. Epub 2010 Apr 15
Vakrou S, Abraham MR. Hypertrophic cardiomyopathy: a heart in need of an energy bar?Front Physiol. 2014 Aug 19;5:309
Stastna M, Abraham MR, Van Eyk JE. Cardiac stem/progenitor cells, secreted proteins and proteomics. FEBS Lett. 2009, Jun 5;583(11):1800-7. Epub 2009 Mar 20.
Chan A, Abraham MR. SPECT and PET to optimize cardiac stem cell therapy. J. Nucl Cardiol., 2012 Feb;19(1):118-25.
Bonios M, Terrovitis J, Abraham MR. Stem cell: ‘Kant’ you see it? J. of Cardiovasc. Trans. Res. 2008, 1:103–105.
Abraham MR, Jahangir A, Terzic A. Channelopathies of inwardly rectifying potassium channels. FASEB J 1999; 13: 1901-1910.
Abraham MR, Hare JM. Is skeletal myoblast transplantation proarrhythmic? The jury is still out. Heart Rhythm, 2006, Apr;3(4):462-3.
Abraham MR, Gerstenblith G. Preconditioning stem cells for cardiovascular disease: An important step forward. Circulation Research, 2007 Mar 2;100(4):447-9.
Cardiac Stem Cells
Patent # WO2006052925 A3 | 05/14/2009
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for autologous, allogeneic, syngeneic, or xenogeneic therapeutic applications in patients. The stem cells can be genetically modified to enhance their therapeutic activity.
Preventing Arrhythmias Associated With Cell Transplantation
Patent # WO2005092033 A3 | 09/27/2007
Skeletal myoblasts are an attractive cell type for transplantation since they are autologous and resistant to ischemia. However, clinical trials of myoblasts transplantation in heart failure have been plagued by ventricular tachy-arrhythmias and sudden cardiac death. The pathogenesis of these arrhythmias is poorly understood, but may be related to the fact that skeletal muscle cells, unlike heart cells, are electrically isolated by the absence of gap junctions. An in vitro model of myoblasts transplantation into cardiomyocyte monolayers can be used to investigate the mechanisms of transplant-associated arrhythmias. Co-cultures of human skeletal myoblasts and rat cardiomyocytes result in reentrant arrhythmias (spiral waves) that reproduce the features of ventricular tachycardia seen in patients receiving myoblasts transplants. These arrhythmias can be terminated by nitrendipine, an L-type calcium channel Mocker, but not by the Na channel blocker lidocaine. Genetic modification of myoblasts to stably express the gap junction protein connexin 43 decreases arrhythmogenicity in co-cultures. It similarly can be used to increase the safety of myoblasts transplantation in patients.