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Maria Roselle Abraham, MD

Co-Director, Hypertrophic Cardiomyopathy Center of Excellence
Assistant Professor of Medicine
Appointment Phone


Main Location

Johns Hopkins Outpatient Center

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Out-of-State & International Patients +
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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Co-Director, Hypertrophic Cardiomyopathy Center of Excellence
  • Assistant Professor of Medicine

Centers & Institutes

  • Heart and Vascular Institute
  • Hypertrophic Cardiomyopathy Service


Arrhythmia, Cardiac Disease, Cardiac Electrophysiology, Cardiology, Cardiomyopathy, Cardiovascular Disease, Chest Pain, Clinical Cardiology, Congestive Heart Failure, Electrophysiology, Event Monitors, General Cardiology, Heart, Heart Attack, Heart Block, Heart Disease, Heart Failure, Holter Monitoring, Hypertrophic Cardiomyopathy, Inherited Arrhythmia Disorders, Inherited Heart Diseases, Irregular Heartbeat, Ischemic Heart Disease, Myocardial Infarction, Myocardial Perfusion Imaging, Palpitations, Paroxysmal Supraventricular Tachycardia, Stress Testing, Stress-induced Cardiomyopathy, Sudden Cardiac Death, Supraventricular Tachycardia, Tachycardias, Valvular Heart Disease

Research Interests

Stem cell engineering; Use of stem cells to repair damaged hearts


Dr. Roselle Abraham is co-director of the Hypertrophic Cardiomyopathy Center of Excellence in the Johns Hopkins Heart and Vascular Institute. She is also the center’s director of research. Dr. Roselle’s research ranges from diagnostic techniques and standards for cardiomyopathy to bioengineering stem cells to improve their effectiveness as therapy for cardiovascular disease, and she holds patents for stem cell applications.

Dr. Abraham graduated from Goa Medical College in India. She completed her internship in internal medicine at Wake Forest University in Winston-Salem, North Carolina and her residency in internal medicine at Parkland Hospital in Dallas, Texas. Dr. Abraham performed fellowships in cardiovascular diseases and in electrophysiology at the Mayo Clinic before joining Johns Hopkins University as a research associate in cardiovascular diseases. She joined the faculty of the Johns Hopkins School of Medicine in 2003 and also teaches bioengineering at Johns Hopkins University.

Dr. Abraham established the Hypertrophic Cardiomyopathy Basic and Translational Research Program at Johns Hopkins Medicine. She has published over 50 journal articles and book chapters, and has functioned as peer reviewer for over a dozen journals.


  • English


1999-Present: Member, American Heart Association (Member, Councils on Clinical Cardiology and Basic Cardiovascular Sciences)

1999-Present: Member, Heart Rhythm society

1999-Present: American College of Cardiology

Additional Resources +
  • Education +


    • Goa Medical College (Panaji - 403001 India) (1989)


    • University of Texas Southwestern Medical School / Internal Medicine (Dallas TX ) (1998)
    • Wake Forest University Baptist Medical Center / Internal Medicine (Winston - Salem NC ) (1996)
    • Goa Medical College / Internal Medicine (Panaji - 403001 India) (1994)
    • Goa Medical College / Pediatrics (Panaji - 403001 India) (1991)


    • Mayo Clinic Medical School College of Medicine / Cardiovascular Disease (Rochester MN ) (2002)
  • Research & Publications +

    Selected Publications

    Recent Publications

    Rachel Ruckdeschel Smith; Lucio Barile; Hee Cheol Cho; Michelle K. Leppo; Joshua M. Hare; Elisa Messina; Alessandro Giacomello; M Roselle Abraham; Eduardo Marbán. Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation. 2007;115(7):896-908.

    Circulation Research. 2005;97(2):159-167.

    Antonio J. Carrasco; Petras P. Dzeja; Alexey E. Alekseev; Darko Pucar; Leonid V. Zingman; M. Roselle Abraham; Denice Hodgson; Martin Bienengraeber; Michel Puceat; Edwin Janssen; et al. Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 2001;98(13):7623-7628.

    Zhou L, Solhjoo S, Millare B, Plank G, Abraham MR, Cortassa S, Trayanova N, O’Rourke B. Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol. 2014 Feb 1;7(1):143-51.

    Soleimanifard S, Abd-Elmoniem KZ, Sasano T, Agarwal HK, Abraham MR, Abraham TP, Prince JL. Three-dimensional regional strain analysis in porcine myocardial infarction: a 3T magnetic resonance tagging study. J Cardiovasc Magn Reson. 2012 Dec 13;14(1):85.

    Saha S, Corona-Villalobos C, Hurtado-de-Mendoza D, Noureldin R, Zimmerman SL, Bluemke DA, Kamel I, Abraham TP, Abraham MR. Higher Cornell product and QTc on exercise stress testing are correlated with lower T1 times by cardiac MRI in hypertrophic Cardiomyopathy. In review

    Rischpler C, Fukushima K, Isoda T, Javadi MS, Dannals RF, Abraham MR, Wahl R, Bengel FM, Higuchi T. Discrepant uptake of the radiolabeled norepinephrine analogues hydroxyephedrine (HED) and Metaiodobenzylguanidine (MIBG) in rat hearts. Eur J Nucl Med Mol Imaging. 2013 Jul;40(7):1077-83.

    Reid B, Afzal JM, McCartney AM, Abraham MR, O’Rourke B, Elisseeff JH. Enhanced tissue production through redox control in stem cell-laden hydrogels. Tissue Eng Part A. 2013 Sep;19(17-18):2014-23.

    Rahman QA, Tereshchenko LG, Kongkatong M, Abraham TP, Abraham MR, Shatkay H. Identifying hypertrophic cardiomyopathy patients by classifying individual heart beats from 12-lead ECG signals. In review.


    Reviews, Book Chapters and Editorials

    Wu JC, Abraham MR, Kraitchman D. Perspectives on imaging cardiac stem cell therapy. J of Nuclear Medicine, 2010 May 1:51 Suppl 1:128S-136S. Epub 2010 Apr 15

    Vakrou S, Abraham MR. Hypertrophic cardiomyopathy: a heart in need of an energy bar?Front Physiol. 2014 Aug 19;5:309

    Stastna M, Abraham MR, Van Eyk JE. Cardiac stem/progenitor cells, secreted proteins and proteomics. FEBS Lett. 2009, Jun 5;583(11):1800-7. Epub 2009 Mar 20.

    Chan A, Abraham MR. SPECT and PET to optimize cardiac stem cell therapy. J. Nucl Cardiol., 2012 Feb;19(1):118-25.

    Bonios M, Terrovitis J, Abraham MR. Stem cell: ‘Kant’ you see it? J. of Cardiovasc. Trans. Res. 2008, 1:103–105.

    Abraham MR, Jahangir A, Terzic A. Channelopathies of inwardly rectifying potassium channels. FASEB J 1999; 13: 1901-1910.

    Abraham MR, Hare JM. Is skeletal myoblast transplantation proarrhythmic? The jury is still out. Heart Rhythm, 2006, Apr;3(4):462-3.

    Abraham MR, Gerstenblith G. Preconditioning stem cells for cardiovascular disease: An important step forward. Circulation Research, 2007 Mar 2;100(4):447-9.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    1998: Guidant/NASPE Electrophysiology Research Award

    1999: Mayo Foundation Clinical Research Award

    2002: American College of Cardiology Career Development Award

    2004: Finalist, AHA Melvin Marcus Young Investigator Award

    2005: Johns Hopkins University Clinician Scientist Award

  • Videos & Media +

    Lectures and Presentations

    • 2011Stem cell therapy: secrets to success. Hellenic Heart Failure Society Meeting, Greece
    • 2011Hypertrophic cardiomyopathy. Institute of Genetic Medicine, JHU
    • 2011SPECT and PET to Assess Cardiac Stem Cell Therapy. ACC Scientific Sessions, New Orleans
    • 2010Promises and pitfalls of stem cell therapy for cardiac regeneration. Cardiology Grand Rounds, JHU
    • 2010Imaging of regenerative therapy. Cardiac PET/CT and SPECT/CT course, JHU
    • 2009Update on Genetics And Sudden Cardiac Death. Keynote address-Women in Electrophysiology conference, Washington D.C.
    • 2009Cardiac-derived stem cell imaging using PET, SPECT. Cardiovascular Molecular Imaging Conference, NIH, Bethesda
  • Events +

    Speaking Engagements

    Stem cell therapy: secrets to success.
    Hellenic Heart Failure Society Meeting

    Hypertrophic cardiomyopathy
    Institute of Genetic Medicine
    Johns Hopkins University

    SPECT and PET to Assess Cardiac Stem Cell Therapy
    ACC Scientific Sessions
    New Orleans

    Imaging of regenerative therapy
    Cardiac PET/CT and SPECT/CT course
    Johns Hopkins University

    Update on Genetics And Sudden Cardiac Death (Keynote address)
    Women in Electrophysiology conference
    Washington, D.C.

    Cardiac-derived stem cell imaging using PET, SPECT
    Cardiovascular Molecular Imaging Conference
    NIH, Bethesda, Md.

    Grand Rounds Lectures

    Promises and pitfalls of stem cell therapy for cardiac regeneration. Cardiology Grand Rounds, JHU, 2010

  • Contact & Locations +


    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    7th Floor
    Baltimore, MD 21287
    Phone: 410-502-2685
    Appointment Phone: 410-502-7974
    Location Map


    • Medicine - Cardiology

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