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Esther Seunghee Oh, MD

Co-Director, Johns Hopkins Memory and Alzheimer''s Treatment Center
Assistant Professor of Medicine
Female
Appointment Phone

410-550-6337

Main Location

Johns Hopkins Bayview Center on Aging and Health-East

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Co-Director, Johns Hopkins Memory and Alzheimer''s Treatment Center
  • Assistant Professor of Medicine
  • Instructor of Pathology

Centers & Institutes

  • Memory and Alzheimer's Disease Treatment Center

Expertise

Geriatric Medicine, Geriatric Psychiatry, Mood Disorders

Research Interests

Development of biomarkers for different stages of dementia, as markers of early detection as well as for markers of treatment response

Languages

  • English

Memberships

1996 present Christian Medical & Dental Associations
2001 present American Geriatrics Society
2006 present Society for Neuroscience
2010 present International College of Geriatric Psychoneuropharmacology

Additional Resources

Additional Resources +
  • Education +

    Training

    • Chicago Medical School/Univ of Hlth Science (Chicago IL) (1998)

    Residencies

    • University of Illinois at Chicago / Internal Medicine (Chicago IL) (2002)

    Fellowships

    • Johns Hopkins University School of Medicine / Geriatric Medicine and Gerontology (Baltimore MD) (2005)

    Certifications

    • American Board of Internal Medicine / Geriatrics (2004)
  • Research & Publications +

    Selected Publications

    Publications: Peer-Reviewed Original Science Research

    1. Tabuchi A, Sano K, Oh E, Tsuchiya T, Tsuda M. Modulation of AP-I Activity by Nitric Oxide (NO) in vitro: NO-Mediated Modulation of AP-I. FEBS Letters, 1994;351:123-127.
    2. Ohtani K, Sakurai H, Oh E, Iwata E, Tsuchiya T, Tsuda M. Involvement of Protein Kinase C in Calcium Signaling Pathway to Activation of AP-I DNA-binding Activity Evoked via NMDA and Voltage-gated Calcium Channels. Journal of Neurochemistry, 1995;65(2):605-614.
    3. Tabuchi A, Oh E, Taoka A, Sakurai H, Tsuchiya T, and Tsuda M. Rapid Attenuation of AP-I Transcriptional Factors Associated with Nitric Oxide (NO) Mediated Neuronal Cell Death. The Journal of Biological Chemistry, 1996;271:31061-31067.
    4. Oh ES, Troncoso JC, Fangmark-Tucker SM. Maximizing the Potential of Plasma Amyloid-beta as a Diagnostic Biomarker for Alzheimers Disease. Neuromolecular Medicine, 2008;10(3):195-207. PMID 18543125, PMC 2558671.
    5. Oh ES, Savonenko AV, King JF, Fangmark-Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC, Amyloid Precursor Protein Increases Cortical Neuron Size in Transgenic Mice. Neurobiology of Aging, 2009; 30(8) 1238-44. PMID 18304698, PMC 2796369.
    6. Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakous JM, Lyketsos CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int. Jr. of Geriatric Psychiatry, Epub (9/10). PMID:20845402
    7. Oh ES, Mielke MM, Rosenberg PB, Jain A, Fedarko NS, Lyketsos CG, Mehta PD. Comparison of Conventional ELISA with Electrochemiluminescence Technology for Detection of Amyloid-beta (Aβ) in Plasma. J Alzheimers Dis, 2010; 21(3):769-73. PMID 20634583 PMC 255878
    8. Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, Oh ES. Immunotherapy attenuates monoaminergic neurodegeneration in transgenic mice. J Alzheimers Dis, 2010. PMID: 20966549

    Book Chapter
    1. Oh ES, Lyketsos CG, Wong PC, Mouse models of Alzheimers disease. In The Principles and Practice of Geriatric Psychiatry, 3rd Ed. Wiley-Blackwell, 2010 in press
    Web Publications

    1. Oh E, A Case of Depression in a Patient with Dementia [educational module for Johns Hopkins Geriatric Education Center] 2006 http://www.hopkinsmedicine.org/gec/studies/depression_dementia.html

    Abstracts

    1. Sakurai H, Oh E, Sano K, Tsuchiya T, Tsuda M. Induction of Novel DNA-Binding Activity in the Cerebellar Granule Cells Stimulated via Glutamate Receptors. 1st UBMB Conference, Biochemistry of Diseases, June 1, 1992.
    2. Sakurai H, Oh E, Sano K, Tabuchi A, Tsuchiya T, Tsuda M. Induction of TRE Binding Activities Mediated by Glutamate Receptors and Its Regulation by Nitric Oxide (NO). Japanese Biochemical Society Meeting. December 9-12, 1992.
    3. Khan A, Oh E, Weisman D, Lesky L. End-Of-Life Curriculum Development at a University Hospital. The Journal of Palliative Medicine, 2001;4:4,533.
    4. Oh, ES., Tucker S, Jankowsky J, Borchelt D,Troncoso J. Peripheral administration of monoclonal antibody as a diagnostic tool to detect soluble amyloid beta. J Am Geriatr Soc., 2005; 53, S19. (Poster presentation).
    5. Oh ES, Tucker SM, Rudow GL, Jankowsky JL, Borchelt DR, Troncoso JC. Passive immunization with monoclonal antibody A 1-11 in transgenic mouse models of Alzheimers disease. American Association of Neuropathologists 2005 Annual Meeting. June 9-12, 2005. (Selected for Podium presentation)
    6. Oh E, Tucker S, Riudavets M, Borchelt D, Troncoso J. The Effect of Anti-amyloid beta Antibody 7B6 on Neuronal Cell Volume. J Am Geriatr. Soc. 2006:54.S156 (Selected for Presidential Poster Session).
    7. Oh E, Tucker S, Smith A, Borchelt D, Troncoso J. Biotinylated anti-Aβ antibody as a tool to diagnose pre-clinical Alzheimers disease (AD). 36th Annual Meeting of the Society for Neuroscience, Oct, 2006 (Poster Presentation).
    8. Oh ES, Tucker S, Borchelt D, Troncoso J. Biotinylated antibody as a tool to diagnose pre-clinical stages of Alzheimer's Disease (AD). J Am Geriatr. Soc. 2007:55.S163 (Selected for Presidential Poster Session).
    9. Oh E, Tucker S, Borchelt D, Troncoso J. Use of a Biotinylated Anti-Aβ Antibody to Diagnose Preclinical Alzheimers Disease. Alzheimers Association Prevention Conference. Alzheimers & Dementia. 2007:3:3 S2 114 (Poster Presentation).
    10. Oh E, Savonenko A, Fangmark-Tucker S, Rudow G, Xu G, Borchelt D, Troncoso J. The Neurotrophic Effects of Amyloid Precursor Protein (APP) on Cortical Neuronal Volumes of Transgenic Mouse Models. 37th Annual Meeting of the Society for Neuroscience, Nov 5, 2007 (Poster Presentation).
    11. K. Abalos, Y. Liu, G. Rudow, J. Troncoso, E. Oh. Attenuation of Catecholaminergic Axons in Asymptomatic Alzheimers disease (ASYMAD). J Am Geriatr.Soc. 2010:58.S180-181.
    12. Oh ES, Mielke MM, Rosenberg PB, Jain A, Fedarko N, Lyketsos CG, Mehta P. Comparison of Conventional ELISA with Electrochemiluminescence Technology for Detection of Amyloid-beta (Aβ) in Plasma. J Am Geriatr.Soc. 2010:58.S121 (Selected for Presidential Poster Session).
    13. Oh ES, Leoutsakos J, Mielke, MM, Rosenberg PB, Troncoso JC, Elahi D, Green PS, Lyketsos, CG, and S. Craft. Oral glucose tolerance test for Alzheimers disease biomarker development. The Rosalinde and Arthur Gilbert Foundation/AFAR Grantee Meeting. June 8, 2010. Santa Barbara, CA. (Poster Presentation).
    14. Oh ES, Parker D, Mielke MM, Rosenberg PB, Jain A, Fedarko NS, Lyketsos CG. Plasma Neopterin Levels in aMCI and AD. International Congress of Geriatric Neuropsychopharmacology Meeting, September 17, 2010. Athens, Greece (Poster Presentation).
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    1990 1990 Student Researcher Department of Neurobiology and Anatomy, University of Rochester, Rochester, NY
    1990 1991 John A. Hartford Foundation Student Researcher Molecular Neurobiology Section, National Institutes of Health, National Institute on Aging, Baltimore, MD
    1991 1992 Student Researcher Department of Microbiology, Okayama University, Okayama, Japan
    1993 1994 Biologist Department of Molecular Cell Biology, American Type Culture Collection (ATCC), Rockville, MD
    1995 1995 Student Researcher National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD
    2002 2005 Post-doctoral Fellow Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD
    2002 2005 Post-doctoral Fellow Division of Neuropathology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
    2005 2008 Instructor Division of Geriatric Medicine and Gerontology, Department of Medicine (primary appointment), Division of Neuropathology, Department of Pathology (secondary appointment), Johns Hopkins University School of Medicine, Baltimore, MD
    2007 present Investigator Clinical Core, Johns Hopkins Alzheimers Disease Research Center
    2008 present Assistant Professor Division of Geriatric Medicine and Gerontology, Department of Medicine (primary appointment), Division of Neuropathology, Department of Pathology (secondary appointment), Johns Hopkins University School of Medicine, Baltimore, MD
  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Center on Aging and Health-East
    5200 Eastern Avenue
    Mason F. Lord Building, 7th Floor
    Baltimore, MD 21224
    Phone: 410-550-1318
    Appointment Phone: 410-550-6337
    Fax: 410-550-8701
    Location Map

    Department/Division

    • Medicine - Geriatric Medicine and Gerontology

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