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Brett Morrison, MD

Brett Michael Morrison, MD
Assistant Professor of Neurology

See Research on Pubmed

Male
Appointment Phone

410-955-2229

Main Location

Johns Hopkins Outpatient Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Assistant Professor of Neurology

Centers & Institutes

  • ALS Clinic
  • Muscular Dystrophy Clinic

Expertise

Amyotrophic Lateral Sclerosis, Myopathy, Neurology, Neuromuscular Disease, Neuromuscular Disorders, Neuropathies

Research Interests

Dr. Morrison's research interests include investigations into the basic mechanisms of cellular metabolism in the nervous system and of neurodegeneration in amyotrophic lateral sclerosis (ALS). Current research focuses on developing novel treatments for ALS and peripheral neuropathies based on augmenting the supply of the energy metabolite, lactate.

Biography

Dr. Brett Morrison specializes in neuromuscular disorders in adults including amyotrophic lateral sclerosis, motor neuropathies, myasthenia gravis and muscle diseases including myopathy and muscular dystrophy.

Dr. Morrisons research interests include investigations into the basic mechanisms of acute denervation and the development of treatments for chronic denervating diseases such amyotrophic lateral sclerosis or motor neuropathies. Current research focuses on treatments designed to reduce muscle loss and atrophy, and thus preserve function, following denervation.

Dr. Brett Morrison received his M.D. and Ph.D. from Mount Sinai Medical School in New York City. He completed his medical internship at the University of Maryland and residency in neurology at The Johns Hopkins Hospital. He then completed a fellowship in Clinical Neurophysiology at The Johns Hopkins Hospital.
Additional Resources +
  • Education +

    Training

    • Mount Sinai Medical Center ( New York NY ) (2001)

    Residencies

    • The Johns Hopkins Hospital/Neurology ( Baltimore MD ) (2005)

    Fellowships

    • The Johns Hopkins Hospital/Clinical Neurophysiology ( Baltimore MD ) (2006)

    Certifications

    • Neuromuscular Medicine, American Board of Psychiatry & Neurology (2008)
    • Neurology, American Board of Psychiatry & Neurology (2006)
  • Research & Publications +

    Selected Publications View all on PubMed

    PEER-REVIEWED PUBLICATIONS:
    1) Morrison, B.M., Gordon, J.W., Ripps, M.E., and Morrison, J.H. (1996) Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability. J. Comp. Neurol. 373 (4): 619-631.
    2) Morrison, B.M., Janssen, W.G., Gordon, J.W., and Morrison, J.H. (1998) Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice. J. Comp. Neurol 391 (1): 64-77.
    3) Morrison, B.M., Janssen, W.G., Gordon, J.W., and Morrison, J.H. (1998) Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice. J. Comp. Neurol. 395: 523-534.
    4) Morrison, B.M., Shu, I-Wei, Wilcox, A.L., Gordon, J.W., and Morrison, J.H. (2000) Early and selective pathology of light chain neurofilament in the spinal cord and sciatic nerve of G86R mutant superoxide dismutase transgenic mice. Exp. Neurol. 165: 207-220.
    5) Kiaei, M., Bush, A.I., Morrison, B.M., Morrison, J.H., Cherny, R.A., Volitakis, I., Beal, M.F., and Gordon, J.W. (2004) Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 24: 7945-7950.
    6) Morrison, B.M., Lang C.H., Vary T.C., Seehra J.S., Wagner K.R. (2007) Pharmacological inhibition of myostatin leads to hypertrophy of denervated and non-denervated muscle by activating protein synthesis. Muscle Nerve, submitted.

    REVIEW ARTICLES AND BOOK CHAPTERS:
    1) Morrison, B.M., Morrison, J.H., and Gordon, J.W. (1998) Superoxide dismutase and neurofilament transgenic models of amyotrophic lateral sclerosis. J. Exp. Zoology 282: 32-47.
    2) Morrison, B.M., Hof, P.R., and Morrison, J.H. (1998) Determinants of neuronal vulnerability in neurodegenerative diseases. Ann. Neurol. 44 (Suppl. 1): S32-S44.
    3) Morrison, B.M., Hof, P.R., and Morrison, J.H. (1998) Determinants of neuronal vulnerability in neurodegenerative diseases. Olanow, C.W. and Jenner, P., eds. Neuroprotection in Parkinsons disease. Beyond the Decade of the Brain, Volume 3. Royal Turnbridge Wells, UK: Wells Medical Limited.
    4) Morrison, B.M., and Morrison, J.H. (1999) Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration. Brain Res. Rev. 29: 121-135.
    5) Morrison, B.M., and Hoke, A. (2004) Clinical cases in neurology from Johns Hopkins. Case 6: when is a headache not just a headache? MedGenMed. 6: 48.

    ABSTRACTS:
    1) Morrison, B.M., Gordon, J.W., Hof, P.R., Ripps, M.E., and Morrison J.H. (1995) Immunohistochemical characterization of degenerating neurons in the spinal cord of mutant superoxide dismutase transgenic mice. Society for Neuroscience Abstract 21, 387.14.
    2) Morrison, B.M., Gordon, J.W., and Morrison, J.H. (1996) Neurochemical markers of vulnerability and protection in mutant superoxide dismutase transgenic mice. Society for Neuroscience Abstract 22, 648.6.
    3) Morrison, B.M, Gordon, J.W. Janssen, W.G., and Morrison J.H. (1997) Distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and mutant superoxide dismutase transgenic mice. Society for Neuroscience Abstract 23, 742-7.
    4) Morrison, B.M., Shetty R.S., Wagner K.R. (2007) Myostatin null mice or mice treated with a pharmacological inhibitor of myostatin have less muscle atrophy in response to denervation than wild-type mice. American Academy of Neurology Annual Meeting: P07.041.
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    Passano Foundation Young Investigator Award, 2006
    Jay Slotkin Research Award, Johns Hopkins Hospital, 2005
    Inductee into Alpha Omega Alpha Honor Society, 2000
    Mount Sinai School of Medicine Doctoral Dissertation Award, 1999
    Morris Bender Award in Clinical Neurology, 1999
    Amyotrophic Lateral Sclerosis Association Research Grant, 1996-1999
    Magna Cum Laude in Neuroscience, Amherst College, 1992
    James Olds Memorial Neuroscience Award, Amherst College, 1992
    Inductee into Sigma Xi Honor Society, 1992
  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    5th floor
    Baltimore, MD 21287
    Phone: 410-502-0796
    Appointment Phone: 410-955-2229
    Location Map

    Department/Division

    • Neurology - Neuromuscular

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