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Brett Morrison, M.D., Ph.D.

Brett Michael Morrison, M.D., Ph.D.

Photo of Dr. Brett Morrison, M.D., Ph.D.

Assistant Professor of Neurology

Male

Expertise: Amyotrophic Lateral Sclerosis, Myopathy, Neurology, Neuromuscular Disease, Neuromuscular Disorders, Neuropathies

Locations

Johns Hopkins Outpatient Center
Appointment Phone: 410-955-2229

601 N. Caroline St.
Baltimore, MD 21287 map
Phone: 410-502-0796

Background

Dr. Brett Morrison specializes in neuromuscular disorders in adults including amyotrophic lateral sclerosis, motor neuropathies, myasthenia gravis and muscle diseases including myopathy and muscular dystrophy.

Dr. Morrisons research interests include investigations into the basic mechanisms of acute denervation and the development of treatments for chronic denervating diseases such amyotrophic lateral sclerosis or motor neuropathies. Current research focuses on treatments designed to reduce muscle loss and atrophy, and thus preserve function, following denervation.

Dr. Brett Morrison received his M.D. and Ph.D. from Mount Sinai Medical School in New York City. He completed his medical internship at the University of Maryland and residency in neurology at The Johns Hopkins Hospital. He then completed a fellowship in Clinical Neurophysiology at The Johns Hopkins Hospital.
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Titles

  • Assistant Professor of Neurology

Departments / Divisions

Education

Degrees

  • MD, Mount Sinai Medical Center (2001)

Residencies

  • Johns Hopkins University School of Medicine / Neurology (2005)

Fellowships

  • Johns Hopkins University School of Medicine / Clinical Neurophysiology (2006)

Board Certifications

  • American Board of Psychiatry & Neurology / Neurology (2006)
  • American Board of Psychiatry & Neurology / Neuromuscular Medicine (2008)

Research & Publications

Research Summary

Dr. Morrison's research interests include investigations into the basic mechanisms of cellular metabolism in the nervous system and of neurodegeneration in amyotrophic lateral sclerosis (ALS).  Current research focuses on developing novel treatments for ALS and peripheral neuropathies based on augmenting the supply of the energy metabolite, lactate.

Selected Publications

View all on Pubmed

PEER-REVIEWED PUBLICATIONS:
1) Morrison, B.M., Gordon, J.W., Ripps, M.E., and Morrison, J.H. (1996) Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability. J. Comp. Neurol. 373 (4): 619-631.
2) Morrison, B.M., Janssen, W.G., Gordon, J.W., and Morrison, J.H. (1998) Time course of neuropathology in the spinal cord of G86R superoxide dismutase transgenic mice. J. Comp. Neurol 391 (1): 64-77.
3) Morrison, B.M., Janssen, W.G., Gordon, J.W., and Morrison, J.H. (1998) Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice. J. Comp. Neurol. 395: 523-534.
4) Morrison, B.M., Shu, I-Wei, Wilcox, A.L., Gordon, J.W., and Morrison, J.H. (2000) Early and selective pathology of light chain neurofilament in the spinal cord and sciatic nerve of G86R mutant superoxide dismutase transgenic mice. Exp. Neurol. 165: 207-220.
5) Kiaei, M., Bush, A.I., Morrison, B.M., Morrison, J.H., Cherny, R.A., Volitakis, I., Beal, M.F., and Gordon, J.W. (2004) Genetically decreased spinal cord copper concentration prolongs life in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci. 24: 7945-7950.
6) Morrison, B.M., Lang C.H., Vary T.C., Seehra J.S., Wagner K.R. (2007) Pharmacological inhibition of myostatin leads to hypertrophy of denervated and non-denervated muscle by activating protein synthesis. Muscle Nerve, submitted.

REVIEW ARTICLES AND BOOK CHAPTERS:
1) Morrison, B.M., Morrison, J.H., and Gordon, J.W. (1998) Superoxide dismutase and neurofilament transgenic models of amyotrophic lateral sclerosis. J. Exp. Zoology 282: 32-47.
2) Morrison, B.M., Hof, P.R., and Morrison, J.H. (1998) Determinants of neuronal vulnerability in neurodegenerative diseases. Ann. Neurol. 44 (Suppl. 1): S32-S44.
3) Morrison, B.M., Hof, P.R., and Morrison, J.H. (1998) Determinants of neuronal vulnerability in neurodegenerative diseases. Olanow, C.W. and Jenner, P., eds. Neuroprotection in Parkinsons disease. Beyond the Decade of the Brain, Volume 3. Royal Turnbridge Wells, UK: Wells Medical Limited.
4) Morrison, B.M., and Morrison, J.H. (1999) Amyotrophic lateral sclerosis associated with mutations in superoxide dismutase: a putative mechanism of degeneration. Brain Res. Rev. 29: 121-135.
5) Morrison, B.M., and Hoke, A. (2004) Clinical cases in neurology from Johns Hopkins. Case 6: when is a headache not just a headache? MedGenMed. 6: 48.

ABSTRACTS:
1) Morrison, B.M., Gordon, J.W., Hof, P.R., Ripps, M.E., and Morrison J.H. (1995) Immunohistochemical characterization of degenerating neurons in the spinal cord of mutant superoxide dismutase transgenic mice. Society for Neuroscience Abstract 21, 387.14.
2) Morrison, B.M., Gordon, J.W., and Morrison, J.H. (1996) Neurochemical markers of vulnerability and protection in mutant superoxide dismutase transgenic mice. Society for Neuroscience Abstract 22, 648.6.
3) Morrison, B.M, Gordon, J.W. Janssen, W.G., and Morrison J.H. (1997) Distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and mutant superoxide dismutase transgenic mice. Society for Neuroscience Abstract 23, 742-7.
4) Morrison, B.M., Shetty R.S., Wagner K.R. (2007) Myostatin null mice or mice treated with a pharmacological inhibitor of myostatin have less muscle atrophy in response to denervation than wild-type mice. American Academy of Neurology Annual Meeting: P07.041.

Activities & Honors

Honors

  • Young Investigator Award, Passano Foundation , 2006
  • Jay Slotkin Research Award, Johns Hopkins Hospital, 2005
  • Inductee into Alpha Omega Alpha Honor Society, 2000
  • Doctoral Dissertation Award, Mount Sinai School of Medicine, 1999
  • Morris Bender Award in Clinical Neurology, 1999
  • Research Grant, Amyotrophic Lateral Sclerosis Association , 1996 - 1999
  • Magna Cum Laude in Neuroscience, Amherst College, 1992
  • James Olds Memorial Neuroscience Award, Amherst College, 1992
  • Inductee into Sigma Xi Honor Society, 1992
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