Dr. Paul Nyquist has an ongoing interest in any translational research project that incorporates well-founded biologic models into patient care in brain injury. He has been involved in a number of clinical trials that have been at the forefront of new technologic innovations in brain injury and has extensive experience in clinical trials in both military and civilian settings. These trials often have involved protocols with high clinical impact on those enrolled.
Dr. Nyquist also has a theoretical focus that emphasizes the role of inflammation in cerebrovascular disease, with particular attention to the effects of inflammation on endothelial activation. He is interested in how inflammation and endothelial activation affect the neurovascular unit. To that end, he is investigating the role of genetic variation on the proclivity of the endothelium to become transformed into a procoagulant state in carotid atherosclerosis.
Using extensive clinical testing for commonly detected risk factors in cerebral vascular disease, Dr. Nyquist is exploring how cerebrovascular small-vessel disease in patients who are predisposed to atherosclerosis may be influenced by inflammation and genetic history. He is also investigating how biomarkers may be used to detect damage in each compartment of the neurovascular unit in the settings of vasospasm and cerebral salt wasting in patients with subarachnoid hemorrhage.
Dr. Nyquist believes that an interrelationship exists between small-vessel disease of the brain and small-vessel disease of the heart and that a number of potential genes may predispose to both. In a study that he conducted in a group of patients who had asymptomatic small-vessel disease of the heart, he found a cross-correlation with silent small-vessel strokes in the brain. His goal is to identify the genes that are associated with cerebral vascular disease in the hopes of developing new treatments for this condition that afflicts millions worldwide.
NIH/NINDS RO-1, Funded, Principal Investigator 1R01NS062059-01A1, GRANT00431125, Occult Small Vessel Cerebrovascular Disease in High Risk Families.
Investigator / Inteventional Management of Stroke (IMS) III NIH Sponsored Clinical Trial
Principal Investigator/ Clinical Trial of rFVIIa (Novoseven) in Patients with
Intracerebral Hemorrhage at Johns Hopkins University, Sponsored by NOVONORDISK
Principal Investigator/ Desmotaplase in Acute Stroke at Johns Hopkins University (DIAS), Sponsored by Forest Pharmaceuticals
Investigator, CLEAR, Use of rt-PA for the Resolution of Clot in Intra-
ventricular Hemorrhage, Sponsored by FDA Orphan Drug Program
Investigator / CREST, Carotid Revascularization Endarterectomy vs. Stent Trial, NIH Sponsored Clinical Trial
Principal Investigator/ Siblings with Ischemic Stroke Study Stroke, INOVA Fairfax Hospital
Department of Defense Sponsored Research Projects
Principle Investigator, Project Officer-1993-1996: Complement Levels in Experimental Divers Before and After Dives with a High Predicted Risk of Decompression Sickness.
Project Officer, Principle Investigator -1994-1996: Desmopressin in Submersion Diueresis in Dives of Long Duration.
Project Officer-1995 - 1997: Human Decompression Trial with 1.3 ATA Oxygen in Helium.63713N.M0099.01A.1510.
Medical Monitor-1995 - 1997: Hyperbarcia Recognition and Thermal Status of Exercising Divers Exposed to Cold Water and Elevated PCO2. 63713N.M0099.01B.1428.
Paul A. Nyquist MD, MPH , Cherie A. Winkler, PhD , Louise M. McKenzie, PhD , Lisa R. Yanek, MPH , Lewis C. Becker, MD , Diane M. Becker, ScD, MPH Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis, Cerebrovascular Disease, accepted.
Paul A Nyquist, Wityck R., Lisa R. Yanek, David Yousem, Lewis C. Becker, Diane M. Becker, High Prevalence of Silent Small Vessel Cerebrovascular Disease and Co-occurrence with Occult Coronary Disease in Healthy Individuals from High Risk Families. Neuroepidemiology accepted
Nyquist P, Stevens RD, Mirski MA. Neurologic injury and mechanical ventilation.
Neurocrit Care. 2008;9(3):400-8. Epub 2008 Aug 12
Stevens RD, Nyquist PA.Types of brain dysfunction in critical illness. Neurol Clin. 2008 May;26(2):469-86, ix
Naval NS, Nyquist PA, Carhuapoma JR.Management of spontaneous intracerebral hemorrhage. Neurol Clin. 2008 May;26(2):373-84, vii.
Toung TJ, Nyquist P, Mirski MA. Effect of hypertonic saline concentration on cerebral and visceral organ water in an uninjured rodent model. Crit Care Med. 2007 Oct 23;
Nyquist P, LeDroux S, Geocadin R. Thrombolytics in intraventricular hemorrhage. Curr Neurol Neurosci Rep. 2007 Nov;7(6):522-8.
Nyquist P, Ball R, Sheridan MJ, Complement levels before and after dives with a high risk of DCS,Undersea Hyperbaric Medicine, UHM 2007, 34(3), 191.
Stevens RD, Nyquist PA. Coma, delirium, and cognitive dysfunction in critical illness.
Crit Care Clin. 2006 Oct;22(4):787-804;
Nyquist PA, Ball R, Sheridan MJ. Complement levels before and after dives with a high predicted risk of decompression sickness. Naval Medical Research Center, Silver Spring, MD. Technical report No. 2006-001; June 2006.
Nyquist P.A., Buttolph T, Dick C., "Detection of leukocyte activation in pigs with neurologic decompression sickness", Aviat Space Environ Med. 2004 Mar;75(3):211-4.
Lattimore SU, Chalela J, Davis L, Degraba T, Ezzeddine M, Haymore J, Nyquist P, Baird AE, Hallenbeck J, Warach S, Impact of establishing a primary stroke center at a community hospital on the use of thrombolytic therapy: the NINDS Suburban Hospital Stroke Center experience. Stroke. 2003 Jun;34(6): 2003 May 15
Worrall BB, Azhar S, Nyquist PA, Ackerman RH, Hamm TL, DeGraba TJ. Interleukin-1 receptor antagonist gene polymorphisms in carotid atherosclerosis. Stroke. 2003 Mar;34(3):790-3
Nyquist PA, Cascino GD, McClelland RL, Annegers JF, Rodriguez M. Incidence of seizures in patients with multiple sclerosis: a population-based study. Mayo Clin. Proc. 2002 Sep;77(9):910-2.
Nyquist PA, Cascino GD, Rodriguez M. Seizures in patients with multiple sclerosis seen at Mayo Clinic, Rochester, Minn., 1990-1998. Mayo Clin. Proc. 2001 Oct;76(10):983-6.
Nyquist P.A., R.D. Brown, Jr., D.O. Wiebers, C.S. Crowson, and W.M. OFallon Circadian and seasonal occurrence of subarachnoid and intracerebral hemorrhage
Neurology. 2001 56: 190-193.
Nyquist P, Laws ER, Elliot E, Novel features of tumors that secrete both growth hormone and prolactin in acromegally, Neurosurgery. Vol. 35, No. 2, 179-185, 1995.