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Lisa Christopher, MD

Director, Johns Hopkins Myositis Center
Associate Professor of Medicine

See Research on Pubmed

Female
Appointment Phone

410-550-6962

Main Location

Johns Hopkins Bayview Medical Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Johns Hopkins Myositis Center
  • Associate Professor of Medicine
  • Associate Professor of Neurology

Centers & Institutes

  • Myositis Center

Expertise

Myositis, Rheumatology

Research Interests

Myositis

Biography

Dr. Christopher-Stine is an Associate Professor of Medicine and Neurology and is  the Director of the Johns Hopkins Myositis Center, a multidisciplinary clinic formally established in 2007 on the Johns Hopkins Bayview campus and one of the largest, most comprehensive centers of its kind worldwide. Over the past 14 years, she has been involved in clinical research related to idiopathic inflammatory myopathies (“myositis”) and has authored or co-authored over 40 publications.

Dr. Christopher-Stine and her colleagues recently discovered that some statin-related myopathies are, in fact, autoimmune in nature. This discovery is a true example of the excellent collaboration and translational research opportunities at Johns Hopkins that has helped to solve a medical mystery and has benefitted patients directly. In her role as the attending inpatient consult rheumatologist, she investigates a wide variety of autoimmune rheumatic diseases including vasculitis, systemic sclerosis, and lupus.

In addition, she serves as a member of The Johns Hopkins Institutional Review Board and enjoys teaching both formally and informally at all levels of medical education from students to fellows to faculty. She takes pleasure in the interplay of her roles as clinician, scientist, and educator.

Languages

  • English

Memberships

Alpha Omega Alpha
Phi Beta Kappa
The American College of Rheumatology (Fellow)
The Myositis Association (Board Member)
Maryland Society for the Rheumatic Diseases (President)

Clinical Trial Keywords

  • Statins
  • Myositis
Additional Resources +
  • Education +

    Training

    • Johns Hopkins Bloomberg School of Public Health (Baltimore MD ) (2004)
    • Hahnemann University School of Medicine (Philadelphia PA ) (1997)

    Residencies

    • Drexel University College of Medicine / Internal Medicine (Philadelphia PA ) (2001)

    Fellowships

    • Johns Hopkins University School of Medicine / Rheumatology (Baltimore MD ) (2003)

    Certifications

    • Rheumatology, American Board of Internal Medicine (2014)
    • Internal Medicine, American Board of Internal Medicine (2000)
  • Research & Publications +

    Research Summary

    Dr. Christopher-Stine’s primary research focus is clinical research pertaining to inflammatory myopathies – specifically describing unique phenotypes, novel therapeutic approaches, and novel disease subsets among patients with inflammatory myopathies who are part of the growing cohort of over 1500 patients evaluated clinically for confirmed or suspected muscle disease at the Myositis Center who agree to be part of the Johns Hopkins Myositis database. Dr. Christopher-Stine and her colleagues made the novel discovery of an autoimmune myopathy closely linked to statins. She has a continued interest in statins and their toxicities toward muscle, both as a direct muscle toxin as well as its contribution to autoimmune muscle injury.

    Dr. Christopher-Stine and her team are currently investigating the burden of calcinosis in adult dermatomyositis by patient self-report and then utilizing novel imaging modalities to examine the extent of calcinosis in these patients. In addition, as patient reported outcomes are growing increasingly important, especially in the context of clinical trials, they are an increasing focus of investigative efforts at the Myositis Center. Specifically, Dr. Christopher-Stine and her team are undertaking an international effort to determine the most appropriate patient-driven outcome measures in the inflammatory myopathies.

    Selected Publications View all on PubMed

      1. Christopher-Stine L, Astor B Petri M, Fine D. Protein:Creatinine Ratio is A Reliable Measure of Proteinuria in Lupus Nephritis. J Rheumatol 2004;31:1557-9.
      2. Kalluri M, Sahn SA, Oddis CV, Gharib, Christopher-Stine, L, Danoff SK, Casciola-Rosen L, Hong G3, Dellaripa PF, Highland KB. Clinical profile of anti-PL-12 autoantibody: Cohort Study and Review of the Literature. Chest. 2009 Jun;135(6):1550-6.
      3. Valiyil R, Hong G, Casciola- Rosen L, Mammen AL, Christopher-Stine, L. Rituximab is an Effective Therapy for Myopathy Associated with Anti-Signal Recognition Particle Antibodies: A Case Series. Arthritis Care Res. 2010 Sep;62(9):1328-34
      4. Christopher-Stine L, Hong G, Casciola-Rosen L, Corse A, Mammen AL. A novel autoantibody recognizing 200 and 100 kDa proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010 Sep;62(9):2757-66
      5. Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase (HMGCR) in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21.
      6. Petri MA, Kiani AN, Post W, Christopher-Stine L, Magder LS. Lupus Atherosclerosis Prevention Study (LAPS).Ann Rheum Dis. 2011 May;70(5):760-5.
      7. Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-HMG-CoA reductase-associated autoimmune myopathy. Arthritis Care Res. 2012 Aug;64(8):1233-7.
      8. Casciola-Rosen L, Hall JC, Christopher-Stine L, Mammen AL, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol. 2012 Jul-Aug;30(4):548-53.
      9. Werner JL, Christopher-Stine L, Ghazarian SR, Pak KS, Kus JE, Daya NR, Lloyd TE Mammen AL. Antibody Levels Correlate with Creatine Kinase Levels and Strength in Anti-HMG-CoA Reductase-Associated Autoimmune Myopathy. Arthritis Rheum. 2012 Dec;64(12):4087-93.
      10. Alexanderson H, Del Grande M, Bingham III CO, Orbai AM, Sarver C, Clegg-Smith K, Lundberg IE, Song YW, Christopher-Stine L. Patient Reported outcomes and Adult Patients’ disease experience in the Idiopathic Inflammatory Myopathies. A report from the OMERACT 11 Myositis Special Interest Group. J Rheumatol. 2014 Apr;41(4):792-8.
      11. ENMC Myositis Muscle Biopsy Study Group. 193rd ENMC International workshop pathology diagnosis of idiopathic inflammatory myopathies 30 November – 2 December 2012, Naarden, The Netherlands. Neuromuscular Disorders 2013 (23): 945–951.
      12. Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L.Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1-gamma. Arthritis Rheum. 2013 Nov;65(11):2954-62.
      13. Sharma K, Orbai AM, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S. Brief Report: Antisynthetase Syndrome-Associated Myocarditis. J Card Fail. 2014 Jul 29
      14. Johnson C, Connors GR, Oaks J, Han S, Truong A, Richardson B, Lechtzin N, Mammen AL, Casciola-Rosen L, Christopher-Stine L, Danoff SK. Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type. Respir Med. 2014 Sep 18
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    2009 Marquis Whos Who in America

    2008 Castle Connolly Medical Ltd. Americas Top Doctors

    2008 Marquis Who''s Who of American Women, 27th Edition (2008-2009)

    2007 Marquis Who''s Who in Science and Engineering, 10th Anniversary (2008-2009) Edition
    2001 The Golden Stethoscope Award Winner
    Presented by the Class of 2001 for excellence in teaching
    2000 The Golden Stethoscope Award Nominee
    1998 C. Nelson Davis Award
    Awarded to a Philadelphia area physician who demonstrates excellence in research and service devoted to addictive disorders
    1998 Wyeth-Ayerst Award for Excellence in Infectious Diseases
    1997 Elizabeth Blackwell Memorial Award to the Outstanding Senior Woman
    1997 Hahnemann Physicians Society Award
    1997 Van Buren O. Hammet Memorial Award Prize for Outstanding Performance in
    Psychiatry
    1997 William Likoff, M.D. Award
    For distinction in patient care and commitment to academic excellence
    1996 Alpha Omega Alpha Honor Society
    1996 Alpha Phi Sorority Howell Memorial Scholarship
    1995 William Goldman Foundation Scholarship
    1995 Betty Ford Center Professional-in-Residence participant
    1992 Phi Beta Kappa Honor Society

    Professional Activities

    2009 The Myositis Association Medical Advisory Board
    2007 Johns Hopkins WorkLife Advisory Group
    2006 ACR Abstract Selection Committee on Myositis and Myopathies
    2005-present Johns Hopkins University Barker Firm Faculty
    2005-present Johns Hopkins University Intern Selection Sub-committee
    2000-2001 Pharmacy and Therapeutics Committee, MCP Hospital, Philadelphia, Pennsylvania
    1998-2001 Graduate Medical Education Committee, MCP Hahnemann University, Philadelphia, Pennsylvania

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Myositis Center
    Baltimore, MD 21224
    Phone: 410-550-6962
    Appointment Phone: 410-550-6962
    Fax: 410-550-3542
    Location Map

    Department/Division

    • Medicine - Clinical and Molecular Rheumatology

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