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Lisa Christopher, MD

Co-Director, Johns Hopkins Myositis Center
Assistant Professor of Medicine

See Research on Pubmed

Female
Appointment Phone

410-550-6962

Main Location

Johns Hopkins Bayview Medical Center

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Out-of-State & International Patients +
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Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Co-Director, Johns Hopkins Myositis Center
  • Assistant Professor of Medicine
  • Assistant Professor of Neurology

Centers & Institutes

  • Myositis Center

Expertise

Myositis, Rheumatology

Research Interests

Myositis

Biography

Dr. Christopher-Stine''s research work, funded by the National Institutes of Health (NIAMS), centers upon the development of a comprehensive database of patients evaluated at The National Institutes of Health with autoimmune myositis and related diseases. Dr. Christopher-Stine is utilizing her training in epidemiology and biostatistics to develop improved diagnostic and classification criteria for these diseases.
Dr. Christopher-Stine has established a prospective myositis cohort at Johns Hopkins Hospital to undertake a longitudinal cohort study and initiate future intervention protocols for patients with autoimmune myositis. She is the principal investigator or co-principal investigator for multiple myositis clinical trials taking place at Johns Hopkins.

She has been instrumental in developing a comprehensive, multidisciplinary center for clinical research in which clinical, serologic, imaging, and pathologic information is collected in a systematic manner, with standardized follow-up at quarterly clinic visits. Additionally, blood samples are collected, on average, twice yearly, including storage for future studies.

Languages

  • English

Memberships

Alpha Omega Alpha
Phi Beta Kappa
The American College of Rheumatology (Fellow)
The Myositis Association (Board Member)
Maryland Society for the Rheumatic Diseases (President)

Clinical Trial Keywords

  • Statins
  • Myositis

Additional Resources

Additional Resources +
  • Education +

    Training

    • Johns Hopkins Bloomberg School of Public Health ( Baltimore MD) (2004)
    • Hahnemann University School of Medicine ( Philadelphia PA) (1997)

    Residencies

    • Drexel University College of Medicine / Internal Medicine ( Philadelphia PA) (2001)

    Fellowships

    • Johns Hopkins University School of Medicine / Rheumatology ( Baltimore MD) (2003)

    Certifications

    • American Board of Internal Medicine / Internal Medicine (2000)
  • Research & Publications +

    Research Summary

    Dr. Christopher-Stine’s primary research focus is clinical research pertaining to inflammatory myopathies – specifically describing unique phenotypes, novel therapeutic approaches, and novel disease subsets among patients with inflammatory myopathies who are part of the growing cohort of over 1500 patients evaluated clinically for confirmed or suspected muscle disease at the Myositis Center who agree to be part of the Johns Hopkins Myositis database. Dr. Christopher-Stine and her colleagues made the novel discovery of an autoimmune myopathy closely linked to statins. She has a continued interest in statins and their toxicities toward muscle, both as a direct muscle toxin as well as its contribution to autoimmune muscle injury.

    Dr. Christopher-Stine and her team are currently investigating the burden of calcinosis in adult dermatomyositis by patient self-report and then utilizing novel imaging modalities to examine the extent of calcinosis in these patients. In addition, as patient reported outcomes are growing increasingly important, especially in the context of clinical trials, they are an increasing focus of investigative efforts at the Myositis Center. Specifically, Dr. Christopher-Stine and her team are undertaking an international effort to determine the most appropriate patient-driven outcome measures in the inflammatory myopathies.

    Selected Publications View all on PubMed

    1. Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L. Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ. Arthritis Rheum. 2013 Nov;65(11):2954-62. doi: 10.1002/art.38093. PMID: 24037894
    2. Park JK, Gelber AC, George M, Danoff SK, Qubti MA, Christopher-Stine L. Pulmonary impairment, not muscle injury, is associated with elevated ESR in the idiopathic inflammatory myopathies. Rheumatology (Oxford). 2013 Jul;52(7):1336-8. doi: 10.1093/rheumatology/ket162. Epub 2013 Apr 24. No abstract available. PMID: 23620561
    3. Subhawong TK, Wang X, Machado AJ, Mammen AL, Christopher-Stine L, Barker PB, Carrino JA, Fayad LM. 1H Magnetic resonance spectroscopy findings in idiopathic inflammatory myopathies at 3 T: feasibility and first results. Invest Radiol. 2013 Jul;48(7):509-16. doi: 10.1097/RLI.0b013e3182823562. PMID: 23563194 
    4. Hall JC, Casciola-Rosen L, Samedy LA, Werner J, Owoyemi K, Danoff SK, Christopher-Stine L. Anti-melanoma differentiation-associated protein 5-associated dermatomyositis: expanding the clinical spectrum. Arthritis Care Res (Hoboken). 2013 Aug;65(8):1307-15. doi: 10.1002/acr.21992. PMID: 23436757
    5. Christopher-Stine L, Robinson DR, Wu CC, Mark EJ. Case records of the Massachusetts General Hospital. Case 37-2012. A 21-year-old man with fevers, arthralgias, and pulmonary infiltrates. N Engl J Med. 2012 Nov 29;367(22):2134-46. doi: 10.1056/NEJMcpc1208147. No abstract available. PMID: 23190225 
    6. Albayda J, Christopher-Stine L. Novel approaches in the treatment of myositis and myopathies. Ther Adv Musculoskelet Dis. 2012 Oct;4(5):369-77. PMID: 23024713 
    7. Werner JL, Christopher-Stine L, Ghazarian SR, Pak KS, Kus JE, Daya NR, Lloyd TE, Mammen AL. Antibody levels correlate with creatine kinase levels and strength in anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Rheum. 2012 Dec;64(12):4087-93. doi: 10.1002/art.34673. PMID: 22933019 
    8. Casciola-Rosen L, Hall JC, Mammen AL, Christopher-Stine L, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol. 2012 Jul-Aug;30(4):548-53. Epub 2012 Aug 29. PMID: 22703875
    9. Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Care Res (Hoboken). 2012 Aug;64(8):1233-7. doi: 10.1002/acr.21671. PMID: 22422616
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    2009 Marquis Whos Who in America

    2008 Castle Connolly Medical Ltd. Americas Top Doctors

    2008 Marquis Who''s Who of American Women, 27th Edition (2008-2009)

    2007 Marquis Who''s Who in Science and Engineering, 10th Anniversary (2008-2009) Edition
    2001 The Golden Stethoscope Award Winner
    Presented by the Class of 2001 for excellence in teaching
    2000 The Golden Stethoscope Award Nominee
    1998 C. Nelson Davis Award
    Awarded to a Philadelphia area physician who demonstrates excellence in research and service devoted to addictive disorders
    1998 Wyeth-Ayerst Award for Excellence in Infectious Diseases
    1997 Elizabeth Blackwell Memorial Award to the Outstanding Senior Woman
    1997 Hahnemann Physicians Society Award
    1997 Van Buren O. Hammet Memorial Award Prize for Outstanding Performance in
    Psychiatry
    1997 William Likoff, M.D. Award
    For distinction in patient care and commitment to academic excellence
    1996 Alpha Omega Alpha Honor Society
    1996 Alpha Phi Sorority Howell Memorial Scholarship
    1995 William Goldman Foundation Scholarship
    1995 Betty Ford Center Professional-in-Residence participant
    1992 Phi Beta Kappa Honor Society

    Professional Activities

    2009 The Myositis Association Medical Advisory Board
    2007 Johns Hopkins WorkLife Advisory Group
    2006 ACR Abstract Selection Committee on Myositis and Myopathies
    2005-present Johns Hopkins University Barker Firm Faculty
    2005-present Johns Hopkins University Intern Selection Sub-committee
    2000-2001 Pharmacy and Therapeutics Committee, MCP Hospital, Philadelphia, Pennsylvania
    1998-2001 Graduate Medical Education Committee, MCP Hahnemann University, Philadelphia, Pennsylvania

  • Videos & Media +
  • Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Myositis Center
    Baltimore, MD 21224
    Phone: 410-550-6962
    Appointment Phone: 410-550-6962
    Fax: 410-550-3542
    Location Map

    Department/Division

    • Medicine - Clinical and Molecular Rheumatology

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