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Photo of Dr. Lisa Christopher

Lisa Christopher, M.D.

Director, Johns Hopkins Myositis Center
Associate Professor of Medicine

Female

Appointment Phone

410-550-6962

Main Location

Johns Hopkins Bayview Medical Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Johns Hopkins Myositis Center
  • Associate Professor of Medicine
  • Associate Professor of Neurology

Centers & Institutes

Departments

Locations

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-6962

4940 Eastern Avenue
Myositis Center
Baltimore, MD 21224 map
Phone: 410-550-6962
Fax: 410-550-3542

Expertise

Myositis, Rheumatology

Biography

Dr. Christopher-Stine is an Associate Professor of Medicine and Neurology and is  the Director of the Johns Hopkins Myositis Center, a multidisciplinary clinic formally established in 2007 on the Johns Hopkins Bayview campus and one of the largest, most comprehensive centers of its kind worldwide. Over the past 14 years, she has been involved in clinical research related to idiopathic inflammatory myopathies (“myositis”) and has authored or co-authored over 40 publications.

Dr. Christopher-Stine and her colleagues recently discovered that some statin-related myopathies are, in fact, autoimmune in nature. This discovery is a true example of the excellent collaboration and translational research opportunities at Johns Hopkins that has helped to solve a medical mystery and has benefitted patients directly. In her role as the attending inpatient consult rheumatologist, she investigates a wide variety of autoimmune rheumatic diseases including vasculitis, systemic sclerosis, and lupus.

In addition, she serves as a member of The Johns Hopkins Institutional Review Board and enjoys teaching both formally and informally at all levels of medical education from students to fellows to faculty. She takes pleasure in the interplay of her roles as clinician, scientist, and educator.

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    Additional Information

  • Education +

    Degrees

    • Hahnemann University School of Medicine / MD (1997)

    Residencies

    • Drexel University College of Medicine / Internal Medicine (2001)

    Fellowships

    • Johns Hopkins University School of Medicine / Rheumatology (2003)

    Certifications

    • American Board of Internal Medicine / Internal Medicine (2000, 2023)
    • American Board of Internal Medicine / Rheumatology (2003, 2014)
  • Research & Publications +

    Clinical Trial Keywords: Statins, Myositis

    Selected Publications View all on PubMed

      1. Christopher-Stine L, Astor B Petri M, Fine D. Protein:Creatinine Ratio is A Reliable Measure of Proteinuria in Lupus Nephritis. J Rheumatol 2004;31:1557-9.
      2. Kalluri M, Sahn SA, Oddis CV, Gharib, Christopher-Stine, L, Danoff SK, Casciola-Rosen L, Hong G3, Dellaripa PF, Highland KB. Clinical profile of anti-PL-12 autoantibody: Cohort Study and Review of the Literature. Chest. 2009 Jun;135(6):1550-6.
      3. Valiyil R, Hong G, Casciola- Rosen L, Mammen AL, Christopher-Stine, L. Rituximab is an Effective Therapy for Myopathy Associated with Anti-Signal Recognition Particle Antibodies: A Case Series. Arthritis Care Res. 2010 Sep;62(9):1328-34
      4. Christopher-Stine L, Hong G, Casciola-Rosen L, Corse A, Mammen AL. A novel autoantibody recognizing 200 and 100 kDa proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010 Sep;62(9):2757-66
      5. Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme a reductase (HMGCR) in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21.
      6. Petri MA, Kiani AN, Post W, Christopher-Stine L, Magder LS. Lupus Atherosclerosis Prevention Study (LAPS).Ann Rheum Dis. 2011 May;70(5):760-5.
      7. Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-HMG-CoA reductase-associated autoimmune myopathy. Arthritis Care Res. 2012 Aug;64(8):1233-7.
      8. Casciola-Rosen L, Hall JC, Christopher-Stine L, Mammen AL, Rosen A. Isolated elevation of aldolase in the serum of myositis patients: a potential biomarker of damaged early regenerating muscle cells. Clin Exp Rheumatol. 2012 Jul-Aug;30(4):548-53.
      9. Werner JL, Christopher-Stine L, Ghazarian SR, Pak KS, Kus JE, Daya NR, Lloyd TE Mammen AL. Antibody Levels Correlate with Creatine Kinase Levels and Strength in Anti-HMG-CoA Reductase-Associated Autoimmune Myopathy. Arthritis Rheum. 2012 Dec;64(12):4087-93.
      10. Alexanderson H, Del Grande M, Bingham III CO, Orbai AM, Sarver C, Clegg-Smith K, Lundberg IE, Song YW, Christopher-Stine L. Patient Reported outcomes and Adult Patients’ disease experience in the Idiopathic Inflammatory Myopathies. A report from the OMERACT 11 Myositis Special Interest Group. J Rheumatol. 2014 Apr;41(4):792-8.
      11. ENMC Myositis Muscle Biopsy Study Group. 193rd ENMC International workshop pathology diagnosis of idiopathic inflammatory myopathies 30 November – 2 December 2012, Naarden, The Netherlands. Neuromuscular Disorders 2013 (23): 945–951.
      12. Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L.Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1-gamma. Arthritis Rheum. 2013 Nov;65(11):2954-62.
      13. Sharma K, Orbai AM, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S. Brief Report: Antisynthetase Syndrome-Associated Myocarditis. J Card Fail. 2014 Jul 29
      14. Johnson C, Connors GR, Oaks J, Han S, Truong A, Richardson B, Lechtzin N, Mammen AL, Casciola-Rosen L, Christopher-Stine L, Danoff SK. Clinical and pathologic differences in interstitial lung disease based on antisynthetase antibody type. Respir Med. 2014 Sep 18
  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Phi Beta Kappa Honor Society, 1992
    • Betty Ford Center Professional-in-Residence participant, 1995
    • Scholarship, William Goldman Foundation , 1995
    • Alpha Omega Alpha Honor Society, 1996
    • Memorial Scholarship , Alpha Phi Sorority Howell , 1996
    • Elizabeth Blackwell Memorial Award to the Outstanding Senior Woman, 1997
    • Hahnemann Physicians Society Award, Hahnemann Physicians Society, 1997
    • Van Buren O. Hammet Memorial Award Prize, 1997
    • William Likoff, M.D. Award, 1997
    • C. Nelson Davis Award , 1998
    • Wyeth-Ayerst Award for Excellence in Infectious Diseases, 1998
    • The Golden Stethoscope Award Nominee, 2000
    • The Golden Stethoscope Award Winner, 2001
    • Who's Who in Science and Engineering, Marquis , 2007
    • Castle Connolly Medical Ltd. Americas Top Doctors, 2008
    • Who's Who of American Women, Marquis , 2008
    • Whos Who in America, Marquis , 2009

    Memberships

    • Alpha Omega Alpha

    Professional Activities

    • Graduate Medical Education Committee, MCP Hahnemann University, 1998 - 2001
    • Pharmacy and Therapeutics Committee, MCP Hospital, 2000 - 2001
    • Barker Firm Faculty , Johns Hopkins University, 2005
    • Intern Selection Sub-committee, Johns Hopkins University, 2005
    • Abstract Selection Committee on Myositis and Myopathies, ACR, 2006
    • WorkLife Advisory Group, Johns Hopkins, 2007
    • Medical Advisory Board, The Myositis Association, 2009
  • Videos & Media +
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