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Fernando Sampaio Goes, M.D.

Photo of Dr. Fernando Sampaio Goes, M.D.

Assistant Professor of Psychiatry and Behavioral Sciences

Male

Languages: English, Portuguese

Expertise: Adult Psychiatry, Affective Disorders, Bipolar Disorder, Depression, Mood Disorders, Psychiatry, Psychiatry and Behavioral Sciences

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410-955-6114
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410-464-6641
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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-6114

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-6114

Background

Titles

  • Assistant Professor of Psychiatry and Behavioral Sciences

Education

Degrees

  • MD, Johns Hopkins University School of Medicine (2002)

Residencies

  • Johns Hopkins University School of Medicine / Psychiatry (2006)

Fellowships

  • Johns Hopkins University School of Medicine / Psychiatry (2008)

Board Certifications

  • American Board of Psychiatry & Neurology / Psychiatry (2007)

Research & Publications

Research Summary

I am a psychiatrist with post-doctoral training in mood disorders and psychiatric genetics. Most of my research focus has been on the genetics of bipolar disorder and I have participated in a number of clinically based genetic studies, being involved in patient recruitment, phenotype assessment and data analyses.

Our research group is involved in a number mood disorder related projects, ranging from laboratory efforts to clinically based pharmacogenetic studies.  As a disease oriented clinician-scientist my goal is to help identify etiological clues that will ultimately facilitate development of novel treatments. I have led a number of genome-wide association analyses of “intermediate” phenotypes between mood and psychotic disorders that may have relevance for both gene discovery and psychiatric nosology. The more recent focus on my work has been to utilize next-generation sequencing technology to uncover the role of rare variation in mood disorder.   I am involved in a number of large-scale studies of bipolar disorder, including both family based and case-control approaches and I also play an active role in the Bipolar Sequencing Consortium, which is performing an ongoing meta-analysis of bipolar sequencing studies

As a complement to the genetic studies, we have also become more involved in functional studies using both post-mortem samples and induced pluripotent stem cell models of mood disorders. This is perform in collaboration with scientists in the division of neuroscience and in the Lieber Institute for Brain Development.

Selected Publications

Goes FS, Pirooznia M, Parla J, Kramer M, Ghiban E, Mavruk S, Chen YC, Monson E, Willour VL, Karchin R, Flickinger M, Locke AE, Levy S, Scott LJ, Boehnke M, BRIDGES Study investigators, Stahl E, Moran JL, Hultman CM, Landén M, Purcell SM, Sklar P, Zandi PP, McCombie WR, Potash JB. Exome sequencing of familial bipolar disorder. JAMA Psychiatry, in press

Pirooznia, M, Wang, T, Aramopoulos D, Potash J, Zandi, P, Goes F. High-throughput Sequencing of the Synaptome in Major Depressive Disorder. Molecular Psychiatry. Jul 28. doi: 10.1038/mp.2015.98

Goes FS, Hamshere M, Seifuddin-F, Mahon-P, Pirooznia-M, The Bipolar Genome Study (BiGS) Consortium, Cichon S, Nothen M, Rietschel M, Schulze TG, Potash JB, and Zandi PP Craddock N, and Potash JB. Genome-wide association of mood-incongruent psychotic bipolar disorder. Translational Psychiatry 2012 Oct 23;2:e180.

Leonpacher, A, Liebers D, Schweizer B, MacKinnon D, Mondimore F, Potash JB, Zandi PP, Goes FS. Distinguishing Bipolar from Unipolar Depression: the importance of clinical symptoms and illness features. Psychol Med. 2015 Aug;45(11):2437-46

Goes,FS, McGrath J, Avramopoulos D, Wolyniec P, Pirooznia M, Ruczinski I, Nestadt G, Kenny E, Vacic V, Peters I, Lencz T, Darvarsi A, Mulle J, Warren ST, Ann E Pulver. Genome-wide association of schizophrenia in the Ashkenazi Jews. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):649-59. doi: 10.1002/ajmg.b.32349. Epub 2015 Jul 21.

Activities & Honors

Honors

  • K99/R00 Transition to Independence Award, NIMH
  • Young Investigator Award, NARSAD
  • Samuel Gershon Young Investigator Award, International Society of Bipolar Disorders
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