I am a psychiatrist with post-doctoral training in mood disorders and psychiatric genetics. Most of my research focus has been on the genetics of bipolar disorder and I have participated in a number of clinically based genetic studies, being involved in patient recruitment, phenotype assessment and data analyses.
Our research group is involved in a number mood disorder related projects, ranging from laboratory efforts to clinically based pharmacogenetic studies. As a disease oriented clinician-scientist my goal is to help identify etiological clues that will ultimately facilitate development of novel treatments. I have led a number of genome-wide association analyses of “intermediate” phenotypes between mood and psychotic disorders that may have relevance for both gene discovery and psychiatric nosology. The more recent focus on my work has been to utilize next-generation sequencing technology to uncover the role of rare variation in mood disorder. I am involved in a number of large-scale studies of bipolar disorder, including both family based and case-control approaches and I also play an active role in the Bipolar Sequencing Consortium, which is performing an ongoing meta-analysis of bipolar sequencing studies
As a complement to the genetic studies, we have also become more involved in functional studies using both post-mortem samples and induced pluripotent stem cell models of mood disorders. This is perform in collaboration with scientists in the division of neuroscience and in the Lieber Institute for Brain Development.
Goes FS, Pirooznia M, Parla J, Kramer M, Ghiban E, Mavruk S, Chen YC, Monson E, Willour VL, Karchin R, Flickinger M, Locke AE, Levy S, Scott LJ, Boehnke M, BRIDGES Study investigators, Stahl E, Moran JL, Hultman CM, Landén M, Purcell SM, Sklar P, Zandi PP, McCombie WR, Potash JB. Exome sequencing of familial bipolar disorder. JAMA Psychiatry, in press
Pirooznia, M, Wang, T, Aramopoulos D, Potash J, Zandi, P, Goes F. High-throughput Sequencing of the Synaptome in Major Depressive Disorder. Molecular Psychiatry. Jul 28. doi: 10.1038/mp.2015.98
Goes FS, Hamshere M, Seifuddin-F, Mahon-P, Pirooznia-M, The Bipolar Genome Study (BiGS) Consortium, Cichon S, Nothen M, Rietschel M, Schulze TG, Potash JB, and Zandi PP Craddock N, and Potash JB. Genome-wide association of mood-incongruent psychotic bipolar disorder. Translational Psychiatry 2012 Oct 23;2:e180.
Leonpacher, A, Liebers D, Schweizer B, MacKinnon D, Mondimore F, Potash JB, Zandi PP, Goes FS. Distinguishing Bipolar from Unipolar Depression: the importance of clinical symptoms and illness features. Psychol Med. 2015 Aug;45(11):2437-46
Goes,FS, McGrath J, Avramopoulos D, Wolyniec P, Pirooznia M, Ruczinski I, Nestadt G, Kenny E, Vacic V, Peters I, Lencz T, Darvarsi A, Mulle J, Warren ST, Ann E Pulver. Genome-wide association of schizophrenia in the Ashkenazi Jews. Am J Med Genet B Neuropsychiatr Genet. 2015 Dec;168(8):649-59. doi: 10.1002/ajmg.b.32349. Epub 2015 Jul 21.