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Photo of Dr. Franco D'Alessio

Franco Rafael D'Alessio, MD

Assistant Professor of Medicine

See Research on Pubmed

Male
Appointment Phone

410-550-5864

Primary Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Assistant Professor of Medicine

Expertise

Critical Care Medicine, Internal Medicine, Pulmonary Medicine

Research Interests

Acute lung injury and its resolution; Interactions between alveolar macrophages and regulatory T cells; Mechanisms underlying Resolution of lung inflammation and injury.

Languages

  • English
  • Spanish

Additional Resources

Additional Resources +
  • Education +

    Training

    • Universidad Peruana Cayetano Heredia ( Lima 31) (2000)

    Residencies

    • Johns Hopkins University School of Medicine/Internal Medicine ( Baltimore MD ) (2004)

    Fellowships

    • Institute Tropical Medicine Alexander Von Humboldt ( Lima) (2001)
    • Johns Hopkins University School of Medicine/Pulmonary and Critical Care Medicine ( Baltimore MD ) (2008)

    Certifications

    • Critical Care Medicine, American Board of Internal Medicine (2011)
    • Pulmonary Disease, American Board of Internal Medicine (2009)
    • Internal Medicine, American Board of Internal Medicine (2004)
  • Research & Publications +

    Selected Publications View all on PubMed

    1. Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May;48(5):635-46. doi: 10.1165/rcmb.2012-0351OC. PMID: 23349051 
    2. Garibaldi BT, D'Alessio FR, Mock JR, Files DC, Chau E, Eto Y, Drummond MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol. 2013 Jan;48(1):35-43. doi: 10.1165/rcmb.2012-0198OC. Epub 2012 Sep 20. PMID: 23002097 
    3. D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 1;189(5):2234-45. doi: 10.4049/jimmunol.1102606. Epub 2012 Jul 27. PMID: 22844117 
    4. Sidhaye VK, Chau E, Srivastava V, Sirimalle S, Balabhadrapatruni C, Aggarwal NR, D'Alessio FR, Robinson DN, King LS. A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS One. 2012;7(6):e38717. doi: 10.1371/journal.pone.0038717. Epub 2012 Jun 8. PMID: 22715407 
    5. Files DC, D'Alessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15;185(8):825-34. doi: 10.1164/rccm.201106-1150OC. Epub 2012 Feb 3. PMID: 22312013
    6. Gurkan OU, He C, Zielinski R, Rabb H, King LS, Dodd-o JM, D'Alessio FR, Aggarwal N, Pearse D, Becker PM. Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury. Exp Lung Res. 2011 Dec;37(10):575-84. doi: 10.3109/01902148.2011.620680. Epub 2011 Nov 1. PMID: 22044313 
    7. Dodd-o JM, Lendermon EA, Miller HL, Zhong Q, John ER, Jungraithmayr WM, D'Alessio FR, McDyer JF. CD154 blockade abrogates allospecific responses and enhances CD4(+) regulatory T-cells in mouse orthotopic lung transplant. Am J Transplant. 2011 Sep;11(9):1815-24. doi: 10.1111/j.1600-6143.2011.03623.x. Epub 2011 Aug 9. PMID: 21827610 
    8. Calvi CL, Podowski M, D'Alessio FR, Metzger SL, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, Cheadle C, Talbot CC Jr, Jie C, McGrath-Morrow S, King LS, Walston J, Neptune ER. Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS One. 2011;6(6):e20712. doi: 10.1371/journal.pone.0020712. Epub 2011 Jun 21. PMID: 21713037 
    9. Rentsendorj O, Damarla M, Aggarwal NR, Choi JY, Johnston L, D'Alessio FR, Crow MT, Pearse DB. Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L161-70. doi: 10.1152/ajplung.00073.2011. Epub 2011 May 13. PMID: 21571906
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Appointment Phone: 410-550-5864
    Location Map
    Johns Hopkins Bayview Medical Center
    5501 Hopkins Bayview Circle
    Asthma and Allergy Center
    Baltimore, MD 21224
    Phone: 410-550-1282
    Appointment Phone: 410-550-5864
    Location Map

    Department/Division

    • Medicine - Pulmonary and Critical Care Medicine

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