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Photo of Dr. Franco D'Alessio

Franco Rafael D'Alessio, M.D.

Assistant Professor of Medicine

Male  | Languages: English, Spanish

Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Assistant Professor of Medicine

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 410-550-5864

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864

5501 Hopkins Bayview Circle
Asthma and Allergy Center
Baltimore, MD 21224 map
Phone: 410-550-1282


Critical Care Medicine , Internal Medicine, Pulmonary Medicine

Research Interests

Mechanisms underlying Resolution of lung inflammation and injury.; Interactions between alveolar macrophages and regulatory T cells; Acute lung injury and its resolution


Dr. Franco Rafael D'Alessio is an assistant professor of medicine at the Johns Hopkins University School of Medicine. His areas of clinical expertise include critical care medicine, internal medicine and pulmonary medicine.

Dr. D'Alessio earned his M.D. from Universidad Peruana Cayetano Heredia. He completed his residency at Johns Hopkins. He performed a fellowship at the Institute Tropical Medicine Alexander Von Humboldt and a fellowship in pulmonary and critical care medicine at Johns Hopkins.

His research interests include mechanisms underlying resolution of lung inflammation and injury and interactions between alveolar macrophages and regulatory T cells. more

    Additional Information

  • Education +


    • Universidad Peruana Cayetano Heredia / MD (2000)


    • Johns Hopkins University School of Medicine / Internal Medicine (2004)


    • Institute Tropical Medicine Alexander Von Humboldt (2001)
    • Johns Hopkins University School of Medicine / Pulmonary and Critical Care Medicine (2008)


    • American Board of Internal Medicine / Critical Care Medicine (2011, 2021)
    • American Board of Internal Medicine / Pulmonary Disease (2009, 2019)
  • Research & Publications +

    Research Summary

    Dr. D’Alessio’s research focuses on immunological determinants of acute lung inflammation and repair, regulatory T cells in lung injury and repair, modulation of alveolar macrophage innate immune response in ARDS, and age-dependent lung immune responses in acute lung injury and ARDS.

    Selected Publications View all on PubMed

    Singer BD, D'Alessio FR. "Histone/protein deacetylase 3 dictates critical aspects of regulatory T cell development and function." Cell Mol Immunol. 2015 Jun 15. doi: 10.1038/cmi.2015.51. [Epub ahead of print] No abstract available.

    Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O. "Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting." Sci Transl Med. 2015 Mar 11;7(278):278ra32. doi: 10.1126/scitranslmed.3010283.

    Singer BD, Mock JR, Aggarwal NR, Garibaldi BT, Sidhaye VK, Florez MA, Chau E, Gibbs KW, Mandke P, Tripathi A, Yegnasubramanian S, King LS, D'Alessio FR. "Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation." Am J Respir Cell Mol Biol. 2015 May;52(5):641-52. doi: 10.1165/rcmb.2014-0327OC.

    D'Alessio FR, Zhong Q, Jenkins J, Moldobaeva A, Wagner EM. "Lung angiogenesis requires CD4(+) forkhead homeobox potein-3(+) regulatory T cells." Am J Respir Cell Mol Biol. 2015 May;52(5):603-10. doi: 10.1165/rcmb.2014-0278OC.

    Rentsendorj O, D'Alessio FR, Pearse DB. "Phosphodiesterase 2A is a major negative regulator of iNOS expression in lipopolysaccharide-treated mouse alveolar macrophages." J Leukoc Biol. 2014 Nov;96(5):907-15. doi: 10.1189/jlb.3A0314-152R. Epub 2014 Jul 25.

    Aggarwal NR, D'Alessio FR, Eto Y, Chau E, Avalos C, Waickman AT, Garibaldi BT, Mock JR, Files DC, Sidhaye V, Polotsky VY, Powell J, Horton M, King LS. Macrophage A2A adenosinergic receptor modulates oxygen-induced augmentation of murine lung injury. Am J Respir Cell Mol Biol. 2013 May;48(5):635-46. doi: 10.1165/rcmb.2012-0351OC. PMID: 23349051

    Garibaldi BT, D'Alessio FR, Mock JR, Files DC, Chau E, Eto Y, Drummond MB, Aggarwal NR, Sidhaye V, King LS. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment. Am J Respir Cell Mol Biol. 2013 Jan;48(1):35-43. doi: 10.1165/rcmb.2012-0198OC. Epub 2012 Sep 20. PMID: 23002097

    D'Alessio FR, Tsushima K, Aggarwal NR, Mock JR, Eto Y, Garibaldi BT, Files DC, Avalos CR, Rodriguez JV, Waickman AT, Reddy SP, Pearse DB, Sidhaye VK, Hassoun PM, Crow MT, King LS. Resolution of experimental lung injury by monocyte-derived inducible nitric oxide synthase. J Immunol. 2012 Sep 1;189(5):2234-45. doi: 10.4049/jimmunol.1102606. Epub 2012 Jul 27. PMID: 22844117

    Sidhaye VK, Chau E, Srivastava V, Sirimalle S, Balabhadrapatruni C, Aggarwal NR, D'Alessio FR, Robinson DN, King LS. A novel role for aquaporin-5 in enhancing microtubule organization and stability. PLoS One. 2012;7(6):e38717. doi: 10.1371/journal.pone.0038717. Epub 2012 Jun 8. PMID: 22715407

    Files DC, DAlessio FR, Johnston LF, Kesari P, Aggarwal NR, Garibaldi BT, Mock JR, Simmers JL, DeGorordo A, Murdoch J, Willis MS, Patterson C, Tankersley CG, Messi ML, Liu C, Delbono O, Furlow JD, Bodine SC, Cohn RD, King LS, Crow MT. A critical role for muscle ring finger-1 in acute lung injury-associated skeletal muscle wasting. Am J Respir Crit Care Med. 2012 Apr 15;185(8):825-34. doi: 10.1164/rccm.201106-1150OC. Epub 2012 Feb 3. PMID: 22312013

    Gurkan OU, He C, Zielinski R, Rabb H, King LS, Dodd-o JM, D'Alessio FR, Aggarwal N, Pearse D, Becker PM. Interleukin-6 mediates pulmonary vascular permeability in a two-hit model of ventilator-associated lung injury. Exp Lung Res. 2011 Dec;37(10):575-84. doi: 10.3109/01902148.2011.620680. Epub 2011 Nov 1. PMID: 22044313

    Dodd-o JM, Lendermon EA, Miller HL, Zhong Q, John ER, Jungraithmayr WM, D'Alessio FR, McDyer JF. CD154 blockade abrogates allospecific responses and enhances CD4(+) regulatory T-cells in mouse orthotopic lung transplant. Am J Transplant. 2011 Sep;11(9):1815-24. doi: 10.1111/j.1600-6143.2011.03623.x. Epub 2011 Aug 9. PMID: 21827610

    Calvi CL, Podowski M, D'Alessio FR, Metzger SL, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, Cheadle C, Talbot CC Jr, Jie C, McGrath-Morrow S, King LS, Walston J, Neptune ER. Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS One. 2011;6(6):e20712. doi: 10.1371/journal.pone.0020712. Epub 2011 Jun 21. PMID: 21713037

    Rentsendorj O, Damarla M, Aggarwal NR, Choi JY, Johnston L, D'Alessio FR, Crow MT, Pearse DB. Knockdown of lung phosphodiesterase 2A attenuates alveolar inflammation and protein leak in a two-hit mouse model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2011 Aug;301(2):L161-70. doi: 10.1152/ajplung.00073.2011. Epub 2011 May 13. PMID: 21571906

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