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Photo of Dr. Nishant Agrawal

Nishant Agrawal, M.D.

Associate Professor of Otolaryngology - Head and Neck Surgery

Male  | Languages: English, Hindi

Appointment Phone


Main Location

Johns Hopkins Outpatient Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Associate Professor of Otolaryngology - Head and Neck Surgery
  • Associate Professor of Oncology

Centers & Institutes



Johns Hopkins Outpatient Center

Appointment Phone: 443-997-6467

601 N. Caroline Street
Baltimore, MD 21287 map
Phone: 410-502-9827
Fax: 410-955-0035

The Johns Hopkins Hospital

Appointment Phone: 443-997-6467

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-502-9827
Fax: 410-955-0035


Benign Tumors of the Head and Neck, Head and Neck Cancers, Laryngeal Cancer, Oral Cancers, Oral Pathology, Oropharynx Cancers, Otolaryngology, Parathyroid Surgery, Parotid Gland Tumors, Pharynx Cancer, Salivary Gland Disorders, Sinonasal Tumors, Skin Cancer of the Head and Neck, Skull Base Tumors, Thyroid Cancer, Thyroid Masses, Thyroid Nodules, Thyroid Surgery, Tonsil Cancer

Research Interests

Head and Neck Cancer Genetics and Diagnostics


Dr. Agrawal specializes in the treatment of benign and malignant tumors of the head and neck.  He has published widely, including a landmark paper on the genomic landscape of head and neck squamous cell carcinoma.  In addition to the genetics of head and neck tumors, Dr. Agrawal's research is focused on the development of biomarkers for screening, monitoring and surveillance of head and neck tumors.  He serves on several committees of national organizations, including American Head and Neck Society and American Thyroid Association. more

Featured Video

Meet Our Experts: Dr. Nishant Agrawal, Head and Neck Surgeon

    Additional Information

  • Education +


    • Johns Hopkins University School of Medicine / MD (2001)


    • Johns Hopkins University School of Medicine / Otolaryngology (2007)


    • Memorial Sloan-Kettering Cancer Center / Oncology (2008)


    • American Board of Otolaryngology / Otolaryngology (2009)
  • Research & Publications +

    Research Summary

    Dr Agrawal’s research is focused on the genetics of head and neck cancer and the development of diagnostic biomarkers for screening, monitoring and surveillance of head and neck cancer.

    Clinical Trials:

    Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx Squamous Cell Carcinoma of Oropharynx (Recruiting)

    Clinical Trial Keywords: head and neck cancer, Squamous Cell Carcinoma of Oropharynx

    Selected Publications View all on PubMed

    Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1. Science. 2011; 333(6046): 1154-1157.

    Bettegowda C, Agrawal N, Jiao Y, Sausen M, Wood LD, Hruban RH, Rodriguez FJ, Cahill DP, McLendon R, Riggins G, Velculescu VE, Oba-Shinjo SM, Marie SK, Vogelstein B, Bigner D, Yan H, Papadopoulos N, Kinzler KW. Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science. 2011; 333(6048): 1453-1455.

    Holdhoff M, Schmidt K, Diehl F, Agrawal N, Angenendt P, Romans K, Edelstein D, Torbenson MS, Kinzler K, Vogelstein B, Choti MA, Diaz LA. Detection of tumor DNA at the margins of colorectal cancer liver metastasis. Clin Cancer Res. 2011; 17(11): 3551-3557.

    Sen N, Hara MR, Ahmad AS, Cascio MB, Kamiya A, Ehmsen JT, Agrawal N, Hester L, Dore S, Synder SH, Sawa A. GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation. Neuron. 2009; 63(1): 81-91.

    Diehl F, Schmidt K, Choti M, Romans K, Goodman S, Li M, Thornton K, Agrawal N, Sokoll L, Szabo SA, Kinzler KW, Vogelstein B, Diaz LA. Circulating tumor DNA to assess tumor dynamics. Nature Medicine. 2008; 14(9): 985-990.

    Farrag TY, Agrawal N, Sheth S, Bettegowda C, Ewertz M, Kim M, Tufano RP. An algorithm for safe and effective re-operative thyroid bed surgery for recurrent/persistent papillary thyroid carcinoma. Head and Neck. 2007; 29(12): 1069-1074.

    Bettegowda C, Foss CA, Cheong I, Wang Y, Diaz LA, Agrawal N, Fox J, Dick J, Dang LH, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging bacterial infections with radiolabeled 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil. PNAS. 2005; 102: 1145-1150.

    Hara MR, Agrawal N, Kim SF, Cascio MB, Fujimuro M, Ozeki Y, Takahashi M, Cheah JH, Tankou SK, Hester LD, Ferris CD, Hayward SD, Snyder SH, Sawa A. S-nitrosylated glyceraldehyde-3-phosphate dehydrogenase initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nature Cell Biology. 2005; 7: 665-674.

    Bae BI, Xu H, Igarashi S, Fujimuro M, Agrawal N, Taya Y, Hayward SD, Moran TH, Montell C, Ross CA, Snyder SH, Sawa A. p53 mediates cellular dysfunction and behavioral abnormalities in Huntington’s disease. Neuron. 2005; 47: 29-41.

    Agrawal N, Bettegowda C, Cheong I, Geschwind J, Drake CG, Hipkiss EL, Tatsumi M, Dang LH, Diaz LA, Pomper M, Abusedera M, Wahl RL, Kinzler KW, Zhou S, Huso DL, Vogelstein B. Bacteriolytic therapy can generate a potent immune response against experimental tumors. PNAS. 2004; 101: 15172-15177.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Waksman Endowment Scholarship, 1994 - 1995
    • Bell Atlantic Scholarship, 1995 - 1996
    • Center for Advanced Biotechnology and Medicine Fellowship, 1995 - 1996
    • Merit Scholarship, Rutgers College , 1996 - 1997
    • Betty Falk Yatvin Memorial Award, 1997
    • Henry Rutgers Scholar, 1997
    • Highest Honors in Biological Sciences, 1997
    • Marvin Harold Cheiten Award, Rutgers College , 1997
    • Scholarship, Johns Hopkins University School of Medicine, 1997 - 1999
    • Owsei Temkin Scholarship, 1999 - 2001
    • Richard Westcott Appleton Scholarship, 2000 - 2001
  • Videos & Media +

    Recent News Articles & Media Coverage

    McCaskey's Steve Powell gets big assists in battle against oral cancer, Lancaster Online (12/11/2014)

    Breakthrough in cancer research at Johns Hopkins' Ludwig Center, WBFF-TV (02/05/2014)

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