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Edward Matthew Schaeffer, M.D., Ph.D.

Director, International Urology
Associate Professor of Urology


Appointment Phone


Main Location

Johns Hopkins Outpatient Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Director, International Urology
  • Co-Director, Prostate Cancer Multi-Disciplinary Clinic
  • Associate Professor of Urology
  • Associate Professor of Oncology

Centers & Institutes


  • Oncology - Prostate Cancer and GU
  • Urology


Johns Hopkins Outpatient Center

Appointment Phone: 410-955-6100

601 N. Caroline Street
Suite 4064
Baltimore, MD 21287 map
Phone: 410-502-2733
Fax: 410-614-8487


Bladder Cancer, Kidney Cancer, Prostate Cancer, Robotic Prostatectomy, Robotic Surgery, Urology, Urology / Urologic Surgery

Research Interests

Urologic surgery; Urology; Robotic surgery; Robotic prostatectomy; Kidney cancer; Bladder cancer; Prostate cancer; Prostate development


Dr. Edward Schaeffer is associate professor of urology and oncology and assistant professor of pathology at the Johns Hopkins School of Medicine. Dr. Schaeffer has an active clinical practice in urologic oncology specializing in prostate, bladder and kidney cancer, and he has expertise in open, laparoscopic and robot treatment of these malignancies.

As an active member of the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Dr. Schaeffer participates in multidisciplinary approaches to the treatment of genitourinary cancers. He is the Director of International Urology and the Co-Director of the Prostate Cancer Multidisciplinary Clinic at Johns Hopkins.

Dr. Schaeffer received his medical training at the University of Chicago and scientific training at the National Institutes of Health. He completed his residency at the Brady Urological Institute at Johns Hopkins. Dr. Schaeffer joined the Johns Hopkins faculty in 2007.

Dr. Schaeffer is also a fully trained scientist and an expert in prostate development and prostate carcinogenesis. His laboratory currently investigates novel pathways of prostate and bladder carcinogenesis through utilization of experimental embryology and systems of epithelial injury repair.

Dr. Schaeffer's accomplishments in both medicine and science have been acknowledged with several awards including the American Urological Association/Astellas "Rising Star" award and a Howard Hughes Clinician-Scientist Early Careers Award. He is a member of Alpha Omega Alpha, the American Urological Association and the American Medical Association. more

Featured Video

Prostate Cancer - Patient Story

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    Additional Information

  • Education +


    • University of Chicago Pritzker School of Medicine / MD PhD (2001)


    • Johns Hopkins University School of Medicine / Urology (2007)


    • American Board of Urology / Urology (2009)
  • Research & Publications +

    Research Summary

    After his grandfather died of prostate cancer, Dr. Edward Schaeffer decided to pursue a career in research to help discover underlying causes of prostate cancer and new treatments for the disease.

    Dr. Schaeffer has been working to understand the molecular factors that create prostate cancer and cause it to spread. He believes clues to cancer’s origins, and its subsequent pathways for growth, lie in the early development of the prostate itself.

    Both prostate cancer and prostate development require male sex hormones called androgens. Dr. Schaeffer and his team have identified several new growth pathways that connect the two, and suggested that a molecule called PLA2 might link androgen-driven prostate cancer growth and prostate inflammation. He hopes that further research on inflammation, androgens, and developmental pathways may lead to new targeted therapies for prostate cancer.

    Additionally, Dr. Schaeffer and his team are working to identify and define molecular subtypes of prostate cancer in patients. Schaeffer has recently published research that defines a subset of very-high-risk localized prostate cancer. By defining and prescribing outcomes for these patients, researchers will be able to better able to tailor treatments, reducing overtreatment for some men and, conversely, increasing treatment intensity in others.

    Clinical Trial Keywords: Prostate Cancer

    Selected Publications View all on PubMed

    1. Sundi D, Wang VM, Pierorazio PM, Han M, Bivalacqua TJ, Ball MW, Antonarakis ES, Partin AW, Schaeffer EM, Ross AE. "Very-high-risk localized prostate cancer: definition and outcomes." Prostate Cancer and Prostatic Disease. 2013 Nov 5. doi: 10.1038/pcan.2013.46. [Epub ahead of print].

    2. Ross AE, Feng FY, Ghadessi M, Erho N, Crisan A, Buerki C, Sundi D, Mitra AP, Vergara IA, Thompson DJ, Triche TJ, Davicioni E, Bergstralh EJ, Jenkins RB, Karnes RJ, Schaeffer EM. "A genomic classifier predicting metastatic disease progression in men with biochemical recurrence after prostatectomy." Prostate Cancer and Prostatic Disease. 2013 Oct 22. doi: 10.1038/pcan.2013.49. [Epub ahead of print].

    3. Pierorazio PM, Gorin MA, Ross AE, Feng Z, Trock BJ, Schaeffer EM, Han M, Epstein JI, Partin AW, Walsh PC, Bivalacqua TJ. "Pathological and oncologic outcomes for men with positive lymph nodes at radical prostatectomy: The Johns Hopkins Hospital 30-year experience." The Prostate. 2013 Nov;73(15):1673-80. doi: 10.1002/pros.22702. Epub 2013 Sep 9.

    4. Sundi D, Ross AE, Humphreys EB, Han M, Partin AW, Carter HB, Schaeffer EM. "African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them?" Journal of Clinical Oncology. 2013 Aug 20;31(24):2991-7. doi: 10.1200/JCO.2012.47.0302. Epub 2013 Jun 17.

    5. Sundi D, Kryvenko ON, Carter HB, Ross AE, Epstein JI, Schaeffer EM. "Pathological examination of radical prostatectomy specimens in men with very low risk disease at biopsy reveals distinct zonal distribution of cancer in black american men." The Journal of Urology. 2014 Jan;191(1):60-7. doi: 10.1016/j.juro.2013.06.021. Epub 2013 Jun 14.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Dean’s List, Johns Hopkins University, 1988 - 1992
    • Third Prize, (ACMI-Circon) resident’s essay contest, 2000
    • First Prize, (Astro-Zeneca) resident’s essay contest, 2001
    • Pfizer scholar in urology, Johns Hopkins Hospital, 2002
    • Praecis scholar in urology, AUA, 2002
    • Prediction of biochemical (PSA) recurrence following radical prostatectomy for clinically localized prostate cancer,” 2002, 2002
    • Second Prize, (Astro-Zeneca) resident’s essay contest, 2002
    • Prostate Cancer SPORE career development award, Northwestern Memorial Hospital, 2003
    • Training Program Scholar, Northwestern University Clinical Investigator, 2003
    • Astellas Rising Star in Urology Award, American Urological Association, 2008 - 2013
    • Passano Foundation’s Clinician Scientist Award, 2008
    • Physician Scientist Early Careers Award, Howard Hughes Medical Institute, 2009
    • Clinician Scientist Award, Johns Hopkins Hospital, 2010


    • American Medical Association, 1994
    • American Urological Association, 2002
    • Alpha Omega Alpha, 2003
  • Videos & Media +


    Open or Robotic Prostate Cancer Surgery Which is Right for You?

    Common Ground: Hope for Prostate Cancer at Johns Hopkins Medicine

    Edward M. Schaeffer, M.D., Ph.D. , Johns Hopkins Medicine, Department of Urology

    Recent News Articles & Media Coverage

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