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Marc Kenneth Halushka, M.D., Ph.D.

Photo of Dr. Marc Kenneth Halushka, M.D., Ph.D.

Director, Oncology Tissue Services (formerly the Tissue Microarray Core)

Associate Professor of Pathology

Male

Expertise: Cardiovascular Diseases, Pathology , Transplant Pathology

Research Interests: Cardiac transplantation; Sudden cardiac death; Endothelial cell biology; MicroRNA expression; Diabetic vascular disease

Locations

The Johns Hopkins Hospital

600 N. Wolfe Street
Ross Research Building 632L
Baltimore, MD 21287 map
Phone: 410-955-9790

Background

Dr. Marc Halushka is an associate professor of pathology and oncology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include cardiovascular pathology, autopsy pathology, and transplant pathology. He is a world-renown expert on cardiovascular tissue microarrays. Dr. Halushka is director of Oncology Tissue Services (formerly the Tissue Microarray Core) for the Johns Hopkins Kimmel Cancer Center.

He earned his M.D. and Ph.D. from Case Western Reserve University School of Medicine. He completed both a residency and fellowship in pathology at the Johns Hopkins School of Medicine.

Dr. Halushka's research interests include diabetic vascular disease, microRNA expression, endothelial cell biology, sudden cardiac death and cardiac transplantation.

In addition to his many roles at Johns Hopkins University School of Medicine, Dr. Halushka is an adjunct associate professor at Perdana University Graduate School of Medicine in Malaysia.

Dr. Halushka was honored with a 2013 Johns Hopkins University School of Medicine International Medical Education Award. He is a member of the American Society of Human Genetics, the American Diabetes Association, the International Society of Heart and Lung Transplantation, and the Society of Cardiovascular Pathology.

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Titles

  • Director, Oncology Tissue Services (formerly the Tissue Microarray Core)
  • Associate Professor of Pathology
  • Associate Professor of Oncology

Education

Degrees

  • MD, Case Western Reserve University School of Medicine (2001)

Residencies

  • Johns Hopkins University School of Medicine / Pathology (2004)

Fellowships

  • Johns Hopkins University School of Medicine / Pathology (2004)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (2005)

Research & Publications

Research Summary

Dr. Halushka’s laboratory is currently working to identify biomarkers of sudden cardiac death and expression patterns of microRNAs in tissues and cells. MicroRNAs are key post-translational regulators of genes. He is interested in determining how microRNAs are altered in human diseases.

His laboratory is also involved in a number of collaborative projects relating to cardiovascular diseases such as sudden cardiac death, cardiac citrullination and neonatal lupus.

Core Facility: Oncology Tissue Services

Selected Publications

View all on Pubmed

Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association For European Cardiovascular Pathology: II. Noninflammatory degenerative diseases - nomenclature and diagnostic criteria. Halushka MK, Angelini A, Bartoloni G, Basso C, Batoroeva L, Bruneval P, Buja LM, Butany J, d'Amati G, Fallon JT, Gallagher PJ, Gittenberger-de Groot AC, Gouveia RH, Kholova I, Kelly KL, Leone O, Litovsky SH, Maleszewski JJ, Miller DV, Mitchell RN, Preston SD, Pucci A, Radio SJ, Rodriguez ER, Sheppard MN, Stone JR, Suvarna SK, Tan CD, Thiene G, Veinot JP, van der Wal AC. Cardiovasc Pathol. 2016 May-Jun;25(3):247-57. doi: 10.1016/j.carpath.2016.03.002. Epub 2016 Mar 12. Review. PMID: 27031798

A benchmark for microRNA quantification algorithms using the OpenArray platform. McCall MN, Baras AS, Crits-Christoph A, Ingersoll R, McAlexander MA, Witwer KW, Halushka MK. BMC Bioinformatics. 2016 Mar 22;17:138. doi: 10.1186/s12859-016-0987-8.

miRge - A Multiplexed Method of Processing Small RNA-Seq Data to Determine MicroRNA Entropy. Baras AS, Mitchell CJ, Myers JR, Gupta S, Weng LC, Ashton JM, Cornish TC, Pandey A, Halushka MK. PLoS One. 2015 Nov 16;10(11):e0143066. doi: 10.1371/journal.pone.0143066. eCollection 2015. PMID: 26571139

Extracellular vesicle microRNA transfer in cardiovascular disease. Das S, Halushka MK. Cardiovasc Pathol. 2015 Jul-Aug;24(4):199-206. doi: 10.1016/j.carpath.2015.04.007. Epub 2015 Apr 28. Review. PMID: 25958013

A draft map of the human proteome. Kim MS, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, Madugundu AK, Kelkar DS, Isserlin R, Jain S, Thomas JK, Muthusamy B, Leal-Rojas P, Kumar P, Sahasrabuddhe NA, Balakrishnan L, Advani J, George B, Renuse S, Selvan LD, Patil AH, Nanjappa V, Radhakrishnan A, Prasad S, Subbannayya T, Raju R, Kumar M, Sreenivasamurthy SK, Marimuthu A, Sathe GJ, Chavan S, Datta KK, Subbannayya Y, Sahu A, Yelamanchi SD, Jayaram S, Rajagopalan P, Sharma J, Murthy KR, Syed N, Goel R, Khan AA, Ahmad S, Dey G, Mudgal K, Chatterjee A, Huang TC, Zhong J, Wu X, Shaw PG, Freed D, Zahari MS, Mukherjee KK, Shankar S, Mahadevan A, Lam H, Mitchell CJ, Shankar SK, Satishchandra P, Schroeder JT, Sirdeshmukh R, Maitra A, Leach SD, Drake CG, Halushka MK, Prasad TS, Hruban RH, Kerr CL, Bader GD, Iacobuzio-Donahue CA, Gowda H, Pandey A. Nature. 2014 May 29;509(7502):575-81. doi: 10.1038/nature13302. PMID: 24870542

Activities & Honors

Honors

  • International Medical Education Award, Johns Hopkins University School of Medicine, 2013
  • Basic Sciences Faculty Teaching Award, Johns Hopkins University School of Medicine, 2011

Memberships

  • American Diabetes Association
  • American Society of Human Genetics
  • International Society of Heart and Lung Transplantation, 2006 - 2015
  • Society of Cardiovascular Pathology
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