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Marc Kenneth Halushka, M.D., Ph.D.

Photo of Dr. Marc Kenneth Halushka, M.D., Ph.D.

Director, Oncology Tissue Services (formerly the Tissue Microarray Core)

Associate Professor of Pathology

Male

Expertise: Cardiovascular Diseases, Pathology , Transplant Pathology

Research Interests: Cardiac transplantation; Sudden cardiac death; Endothelial cell biology; MicroRNA expression; Diabetic vascular disease

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-502-7261

600 N. Wolfe Street
Ross Research Building 632L
Baltimore, MD 21287 map
Phone: 410-502-7261

Background

Dr. Marc Halushka is an associate professor of pathology and oncology at the Johns Hopkins University School of Medicine. His areas of clinical expertise include cardiovascular pathology, autopsy pathology, and transplant pathology. He is a world-renown expert on cardiovascular tissue microarrays. Dr. Halushka is director of Johns Hopkins University Oncology Tissue Services (formerly the Tissue Microarray Core).

He earned his M.D. and Ph.D. from Case Western Reserve University School of Medicine. He completed both a residency and fellowship in pathology at the Johns Hopkins School of Medicine.

Dr. Halushka''s research interests include diabetic vascular disease, microRNA expression, endothelial cell biology, sudden cardiac death and cardiac transplantation.

In addition to his many roles at Johns Hopkins University School of Medicine, Dr. Halushka is an adjunct associate professor at Perdana University Graduate School of Medicine in Malaysia.

Dr. Halushka was honored with a 2013 Johns Hopkins University School of Medicine International Medical Education Award. He is a member of the American Society of Human Genetics, the American Diabetes Association, the International Society of Heart and Lung Transplantation, and the Society of Cardiovascular Pathology.

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Titles

  • Director, Oncology Tissue Services (formerly the Tissue Microarray Core)
  • Associate Professor of Pathology
  • Associate Professor of Oncology

Education

Degrees

  • MD, Case Western Reserve University School of Medicine (2001)

Residencies

  • Johns Hopkins University School of Medicine / Pathology (2004)

Fellowships

  • Johns Hopkins University School of Medicine / Pathology (2004)

Board Certifications

  • American Board of Pathology / Anatomic Pathology (2005)

Research & Publications

Research Summary

Dr. Halushka’s laboratory is currently working to identify biomarkers of sudden cardiac death and expression patterns of microRNAs in tissues and cells. MicroRNAs are key post-translational regulators of genes. He is interested in determining how microRNAs are altered in human diseases.

His laboratory is also involved in a number of collaborative projects relating to cardiovascular diseases such as sudden cardiac death, cardiac citrullination and neonatal lupus.

Core Facility: Oncology Tissue Services

Selected Publications

View all on Pubmed

  1. Sharma K, Orbai AM, Desai D, Cingolani OH, Halushka MK, Christopher-Stine L, Mammen AL, Wu KC, Zakaria S. "Brief Report: Antisynthetase Syndrome-Associated Myocarditis." J Card Fail. 2014 Jul 29. pii: S1071-9164(14)00685-X.
  2. Kent OA, McCall MN, Cornish TC, Halushka MK. "Lessons from miR-143/145: the importance of cell-type localization of miRNAs." Nucleic Acids Res. 2014 Aug 1;42(12):7528-38. doi: 10.1093/nar/gku461. Epub 2014 May 29.
  3. Kim MS, Pinto SM, Getnet D, Nirujogi RS, Manda SS, Chaerkady R, Madugundu AK, Kelkar DS, Isserlin R, Jain S, Thomas JK, Muthusamy B, Leal-Rojas P, Kumar P, Sahasrabuddhe NA, Balakrishnan L, Advani J, George B, Renuse S, Selvan LD, Patil AH, Nanjappa V, Radhakrishnan A, Prasad S, Subbannayya T, Raju R, Kumar M, Sreenivasamurthy SK, Marimuthu A, Sathe GJ, Chavan S, Datta KK, Subbannayya Y, Sahu A, Yelamanchi SD, Jayaram S, Rajagopalan P, Sharma J, Murthy KR, Syed N, Goel R, Khan AA, Ahmad S, Dey G, Mudgal K, Chatterjee A, Huang TC, Zhong J, Wu X, Shaw PG, Freed D, Zahari MS, Mukherjee KK, Shankar S, Mahadevan A, Lam H, Mitchell CJ, Shankar SK, Satishchandra P, Schroeder JT, Sirdeshmukh R, Maitra A, Leach SD, Drake CG, Halushka MK, Prasad TS, Hruban RH, Kerr CL, Bader GD, Iacobuzio-Donahue CA, Gowda H, Pandey A. "A draft map of the human proteome." Nature. 2014 May 29;509(7502):575-81. doi: 10.1038/nature13302.
  4. Outeda P, Huso DL, Fisher SA, Halushka MK, Kim H, Qian F, Germino GG, Watnick T. "Polycystin signaling is required for directed endothelial cell migration and lymphatic development." Cell Rep. 2014 May 8;7(3):634-44. doi: 10.1016/j.celrep.2014.03.064. Epub 2014 Apr 24.
  5. Steppan J, Sikka G, Jandu S, Barodka V, Halushka MK, Flavahan NA, Belkin AM, Nyhan D, Butlin M, Avolio A, Berkowitz DE, Santhanam L. "Exercise, vascular stiffness, and tissue transglutaminase." J Am Heart Assoc. 2014 Apr 10;3(2):e000599. doi: 10.1161/JAHA.113.000599.

McCall MN, Kent OA, Yu J, Fox-Talbot K, Zaiman AL, Halushka MK. MicroRNA profiling of diverse endothelial cell types. BMC Med Genomics, 4(1):78, 2011.

Gupta S*, Halushka MK*, Hilton GM, Arking DE. Postmortem cardiac tissue maintains gene expression profile even after late harvesting. BMC Genomics, 13(1):26, 2012.

Giles JT, Fert-Bober J, Park JK, Bingham CO 3rd, Andrade F, Fox-Talbot K, Pappas D, Rosen A, van Eyk J, Bathon JM, Halushka MK. Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study.. Arth Res Ther. 14(1):R39, 2012.

Kent OA, Fox-Talbot K, Halushka MK. RREB1 repressed miR-143/145 modulates KRAS signaling through down regulation of multiple targets. In Press Oncogene, 2012.

Maleszewski JJ, Murray DL, Dispenzieri A, Grogan M, Judge DP, Caturegli P, Vrana JA, Theis JD, Dogan A, Halushka MK. Relationship between monoclonal gammopathy and cardiac amyloid type. Cardiovasc Pathol, In Press 2012.

Activities & Honors

Honors

  • International Medical Education Award, Johns Hopkins University School of Medicine, 2013
  • Basic Sciences Faculty Teaching Award, Johns Hopkins University School of Medicine, 2011

Memberships

  • American Diabetes Association
  • American Society of Human Genetics
  • International Society of Heart and Lung Transplantation
  • Society of Cardiovascular Pathology
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