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Photo of Dr. Enid Neptune

Enid Rose Neptune, M.D.

Associate Professor of Medicine

Female  | Languages: English, Spanish

Appointment Phone


Main Location

Johns Hopkins Bayview Medical Center

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Associate Professor of Medicine

Centers & Institutes



Johns Hopkins Bayview Medical Center

Appointment Phone: 410-550-5864

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-955-3467

The Johns Hopkins Hospital

Appointment Phone: 410-955-3467

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map


Chronic Obstructive Pulmonary Disease, Critical Care Medicine, Marfan Syndrome, Pulmonary Disease and Critical Care Medicine, Pulmonary Medicine

Research Interests

Therapeutic strategies in Marfan syndrome; Mechanisms and prevention of progression of COPD; Hepatocyte growth factor signaling in airspace homeostasis


Dr. Enid Neptune is an associate professor of medicine at the Johns Hopkins University School of Medicine. Her areas of clinical expertise include chronic obstructive pulmonary disease, critical care medicine and Marfan syndrome. 

Dr. Neptune earned her M.D. from Harvard Medical School. She completed her residency and performed a fellowship in pulmonary and critical care at the University of California, San Francisco. She also performed a fellowship in genetics at Johns Hopkins. 

Her research interests include therapeutic strategies in Marfan syndrome; mechanisms and prevention of progression of COPD; and hepatocyte growth factor signaling in airspace homeostasis.

Dr. Neptune serves on the Compliance Compensation Subcommittee for the Department of Medicine. more

    Additional Information

  • Education +


    • Harvard Medical School / MD (1988)


    • University of California San Francisco / Internal Medicine (1991)


    • University of California San Francisco / Pulmonary and Critical Care Medicine (1998)
    • Johns Hopkins University School of Medicine / Genetics (2001)


    • American Board of Internal Medicine / Critical Care Medicine (1999)
    • American Board of Internal Medicine / Pulmonary Disease (1996)
  • Research & Publications +

    Selected Publications View all on PubMed

    Hansel NN, Paré PD, Rafaels N, Sin DD, Sandford A, Daley D, Vergara C, Huang L, Elliott WM, Pascoe CD, Arsenault BA, Postma DS, Boezen HM, Bossé Y, van den Berge M, Hiemstra PS, Cho MH, Litonjua AA, Sparrow D, Ober C, Wise RA, Connett J, Neptune ER, Beaty TH, Ruczinski I, Mathias RA, Barnes KC; Lung Health Study. "Genome-wide association study identification of novel loci associated with airway responsiveness in chronic obstructive pulmonary disease." Am J Respir Cell Mol Biol. 2015 Aug;53(2):226-34. doi: 10.1165/rcmb.2014-0198OC.

    Lambert AA, Kirk GD, Astemborski J, Neptune ER, Mehta SH, Wise RA, Drummond MB. "A cross sectional analysis of the role of the antimicrobial peptide cathelicidin in lung function impairment within the ALIVE cohort." PLoS One. 2014 Apr 17;9(4):e95099. doi: 10.1371/journal.pone.0095099.

    Poonyagariyagorn HK, Metzger S, Dikeman D, Mercado AL, Malinina A, Calvi C, McGrath-Morrow S, Neptune ER. "Superoxide dismutase 3 dysregulation in a murine model of neonatal lung injury." Am J Respir Cell Mol Biol. 2014 Sep;51(3):380-90. doi: 10.1165/rcmb.2013-0043OC.

    Calvi C, Podowski M, Lopez-Mercado A, Metzger S, Misono K, Malinina A, Dikeman D, Poonyagariyon H, Ynalvez L, Derakhshandeh R, Le A, Merchant M, Schwall R, Neptune ER. "Hepatocyte growth factor, a determinant of airspace homeostasis in the murine lung." PLoS Genet. 2013;9(2):e1003228. doi: 10.1371/journal.pgen.1003228. Epub 2013 Feb 14.

    Hansel NN, Ruczinski I, Rafaels N, Sin DD, Daley D, Malinina A, Huang L, Sandford A, Murray T, Kim Y, Vergara C, Heckbert SR, Psaty BM, Li G, Elliott WM, Aminuddin F, Dupuis J, O'Connor GT, Doheny K, Scott AF, Boezen HM, Postma DS, Smolonska J, Zanen P, Mohamed Hoesein FA, de Koning HJ, Crystal RG, Tanaka T, Ferrucci L, Silverman E, Wan E, Vestbo J, Lomas DA, Connett J, Wise RA, Neptune ER, Mathias RA, Paré PD, Beaty TH, Barnes KC. "Genome-wide study identifies two loci associated with lung function decline in mild to moderate COPD." Hum Genet. 2013 Jan;132(1):79-90. doi: 10.1007/s00439-012-1219-6. Epub 2012 Sep 18.

    Calvi CL, Podowski M, D'Alessio FR, Metzger SL, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, Cheadle C, Talbot CC Jr, Jie C, McGrath-Morrow S, King LS, Walston J, Neptune ER. Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS One. 2011;6(6):e20712. doi: 10.1371/journal.pone.0020712. Epub 2011 Jun 21. PMID: 21713037

  • Academic Affiliations & Courses +
  • Activities & Honors +

    Professional Activities

    • Compliance Compensation Subcommittee, Johns Hopkins Department of Medicine, Baltimore, MD
  • Videos & Media +

    Recent News Articles & Media Coverage

    Fighting To Breathe: Living With COPD,” NPR, June 12, 2013

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