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Dung Thi Le, M.D.

Photo of Dr. Dung Thi Le, M.D.

Associate Professor of Oncology


Languages: English, Vietnamese

Expertise: Anal Cancer, Bile Duct Cancer, Carcinoid Syndrome, Carcinoid Tumors, Cholangiocarcinoma, Colon Cancer, Colorectal Cancer, Gastric Cancer, Gastroesophageal Junction Cancer, Gastrointestinal Cancers, Gastrointestinal Tumors, Hepatocellular Cancer, Liver Cancer, Medical Oncology, Neuroendocrine Tumors, Pancreatic Cancer, Rectal Cancer, Small Bowel Cancer, Small Intestine Cancer, Stomach Cancer more

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Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
Appointment Phone: 410-955-8893

401 N. Broadway
Baltimore, MD 21231 map
Phone: 443-287-0002
Fax: 443-287-4653



Dung Le, M.D. is an assistant professor of gastrointestinal cancers at The Johns Hopkins Kimmel Cancer Center.  Her research interests include novel approaches to patients with gastrointestinal malignancies. She has served as the principal investigator (PI) on many clinical trials focused on testing immunotherapy in patients with gastrointestinal malignancies and she has also served as tthe national PI on several studies including: anti-programmed death-1 (PD-1_ in tumors with mismatch repair deficiency; a clinical trial in advanced pancreatic cancer patients evaluating the safety, tolerability and immune response to CRS-207, a listeria vaccine platform which has been modified to express teh tumor antigen mesothelin; a multi-center, phase 2 study testing CRS-207 as a boost to allogenic pancreatic tumor cells transfected with GM-CSF gene (GVAX) for treatment of advanced pancreatic adenocarcinoma (PDA); a trial testing GVAX/ipilimumab in the maintenance setting for metastatic pancreatic cancer; and GVAX/CRS-207 +/- nivolumab in metastatic pancreatic cancer.

These studies incorporate extensive laboratory correlates and have involved collaborations with clinicians and bench scientists with expertise in the fields of immunotherapy and cancer genomics. Dung Le's experience will contribute to the success of the proposals in this application. more


  • Associate Professor of Oncology

Departments / Divisions



  • MD, Johns Hopkins University School of Medicine (2001)


  • Johns Hopkins University School of Medicine / Medicine (2004)


  • Johns Hopkins University School of Medicine / Oncology (2007)

Board Certifications

  • American Board of Internal Medicine / Medical Oncology (2007)

Research & Publications

Selected Publications

View all on Pubmed

Alphs, H.H.; Eisele, D.W.; Westra, W.H. The role of fine needle aspiration in the evaluation of parotid masses. Curr Opin Otolaryngol Head Neck Surg. 2006 Apr;14(2):62-66.

Sauerwald, T.M.; Figueroa, B., Jr.; Hardwick, J.M.; Oyler, G.A.; Betenbaugh, M.J. Combining caspase and mitochondrial dysfunction inhibitors of apoptosis to limit cell death in mammalian cell cultures. Biotechnol Bioeng. 2006 Jun 5;94(2):362-372.

Han, L.; Witmer, P.D.; Casey, E.; Valle, D.; Sukumar, S. DNA methylation regulates MicroRNA expression. Cancer Biol Ther. 2007 Aug;6(8):1284-1288.

Karp, J.E.; Lancet, J.E. Development of farnesyltransferase inhibitors for clinical cancer therapy: focus on hematologic malignancies. Cancer Invest. 2007 Sep;25(6):484-494.

Cameron, D.; Casey, M.; Press, M.; Lindquist, D.; Pienkowski, T.; Romieu, C.G.; Chan, S.; Jagiello-Gruszfeld, A.; Kaufman, B.; Crown, J.; Chan, A.; Campone, M.; Viens, P.; Davidson, N.; Gorbounova, V.; Raats, J.I.; Skarlos, D.; Newstat, B.; Roychowdhury, D.; Paoletti, P.; Oliva, C.; Rubin, S.; Stein, S.; Geyer, C.E. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat. 2008 Dec;112(3):533-543.

Forastiere, A.A.; Ang, K.K.; Brizel, D.; Brockstein, B.E.; Burtness, B.A.; Cmelak, A.J.; Colevas, A.D.; Dunphy, F.; Eisele, D.W.; Goepfert, H.; Hicks, W.L., Jr.; Kies, M.S.; Lydiatt, W.M.; Maghami, E.; Martins, R.; McCaffrey, T.; Mittal, B.B.; Pfister, D.G.; Pinto, H.A.; Posner, M.R.; Ridge, J.A.; Samant, S.; Schuller, D.E.; Shah, J.P.; Spencer, S.; Trotti, A., 3rd; Weber, R.S.; Wolf, G.T.; Worden, F. Head and neck cancers. J Natl Compr Canc Netw. 2008 Aug;6(7):646-695.

Gao, P.; Dang, C.V.; Watson, J. Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. J Am Assoc Lab Anim Sci. 2008 Nov;47(6):37-40.

Inge, L.J.; Rajasekaran, S.A.; Wolle, D.; Barwe, S.P.; Ryazantsev, S.; Ewing, C.M.; Isaacs, W.B.; Rajasekaran, A.K. alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling. Mol Cancer Ther. 2008 Jun;7(6):1386-1397.

Laheru, D.; Lutz, E.; Burke, J.; Biedrzycki, B.; Solt, S.; Onners, B.; Tartakovsky, I.; Nemunaitis, J.; Le, D.; Sugar, E.; Hege, K.; Jaffee, E. Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation. Clin Cancer Res. 2008 Mar 1;14(5):1455-1463.

Le, D.; Jaffee, E.M.; Laheru, D.A. Development of Vaccine Therapy for Pancreas Cancer. In: Andrew Lowy, S.L., Philip Philip, editor. 1 ed, Pancreatic Cancer. New York: Springer; 2008.

Le, D.; Kim, P.; Jaffee, E.M. Current Cancer Therapeutics. In: David Ettinger, R.D., editor, Cancer Vaccines. Philadelphia: Current Medicine, LLC; 2008.

Le, D.T.; Kim, P.S.; Jaffee, E.M. Role of Tolerance in Cancer Immunotherapy. In: Vincent T. Devita, T.S.L., Steven Rosenber, editor, Principles and Practice of Oncology Focus Series. New York: Wolters Kluwer Health; 2008.

Sun, J.; Lange, E.M.; Isaacs, S.D.; Liu, W.; Wiley, K.E.; Lange, L.; Gronberg, H.; Duggan, D.; Carpten, J.D.; Walsh, P.C.; Xu, J.; Chang, B.L.; Isaacs, W.B.; Zheng, S.L. Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients. Prostate. 2008 Apr 1;68(5):489-497.

Wu, J.M.; Fackler, M.J.; Halushka, M.K.; Molavi, D.W.; Taylor, M.E.; Teo, W.W.; Griffin, C.; Fetting, J.; Davidson, N.E.; De Marzo, A.M.; Hicks, J.L.; Chitale, D.; Ladanyi, M.; Sukumar, S.; Argani, P. Heterogeneity of breast cancer metastases: comparison of therapeutic target expression and promoter methylation between primary tumors and their multifocal metastases. Clin Cancer Res. 2008 Apr 1;14(7):1938-1946.

Zhang, L.; Fried, F.B.; Guo, H.; Friedman, A.D. Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood. 2008 Feb 1;111(3):1193-1200.

Hulleman, E.; Kazemier, K.M.; Holleman, A.; VanderWeele, D.J.; Rudin, C.M.; Broekhuis, M.J.; Evans, W.E.; Pieters, R.; Den Boer, M.L. Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. Blood. 2009 Feb 26;113(9):2014-2021.

Keerthikumar, S.; Raju, R.; Kandasamy, K.; Hijikata, A.; Ramabadran, S.; Balakrishnan, L.; Ahmed, M.; Rani, S.; Selvan, L.D.; Somanathan, D.S.; Ray, S.; Bhattacharjee, M.; Gollapudi, S.; Ramachandra, Y.L.; Bhadra, S.; Bhattacharyya, C.; Imai, K.; Nonoyama, S.; Kanegane, H.; Miyawaki, T.; Pandey, A.; Ohara, O.; Mohan, S. RAPID: Resource of Asian Primary Immunodeficiency Diseases. Nucleic Acids Res. 2009 Jan;37(Database issue):D863-867.

Fonseca, R.; Richardson, P.; Giralt, S.; Lonial, S.; Rajkumar, S.V.; Stewart, A.K.; Bensinger, W.; Somlo, G.; Vescio, R.; Mikhael, J.; Reeder, C.; Tiedemann, R.; Tricot, G.; Rifkin, R.; Shaughnessy, J.; Munshi, N.; Raje, N.; Ghobrial, I.; Laubach, J.; Schlossman, R.; Treon, S.; Mahindra, A.; Avigan, D.; Rosenblatt, J.; Jagannath, S.; Niesvizky, R.; Landau, H.; Chen-Kiang, S.; Siegel, D.S.; Zimmerman, T.; Mehta, J.; Vesole, D.; Rosen, S.; Hofmeister, C.; Lacy, M.; Dispenzieri, A.; Borrello, I.; Hayman, S.R.; Kumar, S.; Buadi, F.; Dingli, D.; Russell, S.; Melissa Alsina, M.A.; Fernandez, H.; Roy, V.; Pereira, D.; Stadtmauer, E.; Vij, R.; Jakubowiak, A.; Lentzsch, S.; Song, K.; Trudel, S.; Chen, C.; Reece, D.; Stewart, D.; Singhal, S.; Comenzo, R.; Gertz, M.A.; Greipp, P.R.; Durie, B.; Barlogie, B.; Anderson, K.; Dalton, W.; Coleman, M.; Novis, S.; Kyle, R.A. Conflicts of interest, authorship, and disclosures in industry-related scientific publications. Mayo Clin Proc. 2010 Feb;85(2):197-199; author reply 201-194.

Huang, C.R.; Schneider, A.M.; Lu, Y.; Niranjan, T.; Shen, P.; Robinson, M.A.; Steranka, J.P.; Valle, D.; Civin, C.I.; Wang, T.; Wheelan, S.J.; Ji, H.; Boeke, J.D.; Burns, K.H. Mobile interspersed repeats are major structural variants in the human genome. Cell. 2010 Jun 25;141(7):1171-1182.

Kavran, J.M.; Ward, M.D.; Oladosu, O.O.; Mulepati, S.; Leahy, D.J. All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 2010 Aug 6;285(32):24584-24590.

Kohli, R.M.; Maul, R.W.; Guminski, A.F.; McClure, R.L.; Gajula, K.S.; Saribasak, H.; McMahon, M.A.; Siliciano, R.F.; Gearhart, P.J.; Stivers, J.T. Local sequence targeting in the AID/APOBEC family differentially impacts retroviral restriction and antibody diversification. J Biol Chem. 2010 Dec 24;285(52):40956-40964.

Le, D.T.; Ladle, B.H.; Lee, T.; Weiss, V.; Yao, X.; Leubner, A.; Armstrong, T.D.; Jaffee, E.M. CD8(+)Foxp3(+) tumor infiltrating lymphocytes accumulate in the context of an effective anti-tumor response. Int J Cancer. 2010 Sep 20.
Le, D.T.; Pardoll, D.M.; Jaffee, E.M. Cellular vaccine approaches. Cancer J. 2010 Jul-Aug;16(4):304-310.

Lutz, E.; Yeo, C.J.; Lillemoe, K.D.; Biedrzycki, B.; Kobrin, B.; Herman, J.; Sugar, E.; Piantadosi, S.; Cameron, J.L.; Solt, S.; Onners, B.; Tartakovsky, I.; Choi, M.; Sharma, R.; Illei, P.B.; Hruban, R.H.; Abrams, R.A.; Le, D.; Jaffee, E.; Laheru, D. A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation. Ann Surg. 2011 Jan 6;Epub 1/11/11.
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