Dr. Stevens’ research centers on quantitative approaches to injury and repair within the central nervous system.
His group seeks to generate a comprehensive anatomical and functional map of neural injury and repair following insults such as trauma, stroke, anoxia and sepsis. Several projects have evaluated the relationship between critical illness and central or peripheral nervous system dysfunction. Ongoing projects deploy quantitative brain mapping to probe recovery of consciousness and cognitive function in patients who have experienced acute neurologic insults from trauma, stroke, cardiac arrest and sepsis.
Dr. Stevens is the principal investigator in a study funded by the Brain Science Institute to track recovery after severe traumatic brain injury using multiparametric MRI and tablet-based neuropsychological assessments. He leads the Neuroimaging for Coma Emergence and Recovery (NICER) project, a multi-site, prospective observational cohort study of patients with severe traumatic brain injury who are serially evaluated with MRI and detailed cognitive phenotype analysis. The overarching goal is to generate transformative interventions for neurological recovery.
Clinical Trial Keywords:
Traumatic brain injury, stroke, subarachnoid hemorrhage, delirium, sepsis, ICU-acquired weakness
Salluh JI, Wang H, Schneider EB, Nagaraja N, Yenokyan G, Damluji A, Serafim RB, Stevens RD. Outcome of delirium in critically ill patients: systematic review and meta-analysis. BMJ 2015;350:h2538. doi: 10.1136/bmj.h2538.
Sutter R, Stevens RD, Kaplan PW. Clinical and imaging correlates of EEG patterns in hospitalized patients with encephalopathy. J Neurol 2012;260:1087-98.
Polito A, Eischwald F, Le Maho AL, Polito A, Azabou E, Annane D, Chrétien F, Stevens RD, Carlier R, Sharshar T. Pattern of brain injury in the acute setting of human septic shock. Crit Care. 2013 Sep 18;17(5):R204.
Stevens RD, Sutter R. Prognosis in severe brain injury. Crit Care Med 2013; 41:1104-23.
Sutter R, Stevens RD, Kaplan PW. Significance of triphasic waves in patients with acute encephalopathy: a nine-year cohort study. Clin Neurophysiol. 2013;124(10):1952-8
Dinkel J, Drier A, Khalilzadeh O, Perlbarg V, Czernecki V, Gupta R, Gomas F, Sanchez P, Dormont D, Galanaud D, Stevens RD, Puybasset L Long-Term White Matter Changes after Severe Traumatic Brain Injury: A 5-Year Prospective Cohort. AJNR Am J Neuroradiol 2013
Galanaud D, Perlbarg V, Gupta R, Stevens RD, Sanchez P, Veber B, Tollard E, Faivre S, Soto-Ares G, Cottenceau V, Tourdias T, André E, Menjot de Champfleur E, Audibert G, Bracard S, Dailler F, Ibarrola D, Payen JF, Le Bas JF, Bruder N, Girard N, Vanhaudenhuyse A, Tshibanda L, Laureys S, Benali H, Puybasset L for the NICER (Neuro Imaging in Coma Emergence and Recovery). Assessment of White Matter Injury and Outcome in Severe Brain Trauma: a Prospective Multi-center Cohort. Anesthesiology 2012; 117:1300–1310
Luyt CE, Galanaud D, Perlbarg V, Vanhaudenhuyse A, Stevens RD, Gupta R, Besancenot H, Krainik A, Audibert G, Combes A, Chastre J, Benali H, Laureys S and Puybasset L. Diffusion tensor imaging to predict long-term outcome following cardiac arrest. Anesthesiology 2012; 117:1311–1321
Huff JS, Stevens RD, Weingart SD, Smith WS. Emergency neurological life support: approach to the patient with coma. Neurocrit Care. 2012;17Suppl 1:S54-9.
Hoesch RE, Lin E, Young M, Gottesman RF, Altaweel L, Nyquist PA, Stevens RD. Acute Lung Injury in Critical Neurological Illness. Crit Care Med 2012; 40:587-93.
Frattalone A, Stevens RD. Intracranial pressure and its surrogates. Intensive Care Med 2011; 37(7):1051-3
Stevens RD, Puybasset L. The brain-lung-brain axis. Intensive Care Medicine 2011;37(7):1054-6
Hua J, Stevens RD, Huang AJ, Pekar JJ, van Zijl PC. Physiological origin for the BOLD poststimulus undershoot in human brain: vascular compliance versus oxygen metabolism. J Cereb Blood Flow Metab 2011;31:1599-611
Duckworth J, Stevens RD. Imaging brain trauma. Current Opinion in Critical Care 2010'16:92–97
Stevens RD, Marshall S, Cornblath DC, De Johghe B, Ali N, Needham DM, Sharshar T. A Framework for Diagnosing and Classifying Intensive Care Unit Acquired Weakness. Critical Care Med 2009;37[Suppl.]:S299 –S308
Donahue MJ, Stevens RD, de Boorder M, van Zijl PC. Hemodynamic changes after visual stimulation and breath holding provide evidence for an uncoupling of cerebral blood flow and volume from oxygen metabolism. J Cereb Blood Flow Metab 2009;29:176-85
Koenig MA, Bryan M, Mirski MA, Geocadin RG, Stevens RD. Reversal of brain herniation with 23.4% saline. Neurology 2008; 70:1023-9.
Stevens RD, Pronovost PJ. The spectrum of encephalopathy in critical illness. Semin Neurol 2006;26:440–451 18.
Stevens RD, Bhardwaj A. Approach to the comatose patient. Crit Care Med 2006; 34:31-41.
Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular Dysfunction Acquired in Critical Illness. A Systematic Review. Intensive Care Med 2007;33:1876-91
Stevens RD, Bhardwaj A. Evolving paradigms in the management of traumatic brain injury. Crit Care Med 2005 2005;33:2415-7