Dr. Kim’s chief research interest is in the pathogenesis of sepsis and central nervous system (CNS) infections, using microbial genomics and proteomics. Sepsis and CNS infections are prevalent and remain the major causes of mortality and morbidity throughout the world; attempts to control such diseases have been hampered by incomplete knowledge of the pathogenesis. Dr. Kim’s group is the first to show, using E. coli, how bacteria translocate from blood to the CNS. His group is also one of the first to show that endotoxin requires soluble CD14 for activating endothelial cells. His continued investigations of microbes-host interactions pertaining to pathogenesis will lead to development of novel strategies (e.g., vaccines) to prevent sepsis and CNS infections.
Clinical Trial Keywords:
antimicrobial agents, vaccines
Agostoni C, Kim KS. "Nutrition and the microbiome 2015." Pediatr Res. 2015 Jan;77(1-2):113-4. doi: 10.1038/pr.2014.195.
Kumar G, Date OS, Kim KS, Manjunath R. "Infection of human amniotic and endothelial cells by Japanese encephalitis virus: Increased expression of HLA-F." Virology. 2014 Dec;471-473:29-37. doi: 10.1016/j.virol.2014.09.022. Epub 2014 Oct 20.
Tan YC, Gill AK, Kim KS. "Treatment strategies for central nervous system infections: an update." Expert Opin Pharmacother. 2015 Feb;16(2):187-203. doi: 10.1517/14656566.2015.973851. Epub 2014 Oct 18.
Kim MJ, Yang KW, Kim SS, Park SM, Park KJ, Kim KS, Choi YH, Cho KK, Hyun CG. "Chemical composition and anti-inflammation activity of essential oils from Citrus unshiu flower." Nat Prod Commun. 2014 May;9(5):727-30.
Tarazi C, Agostoni C, Kim KS. "The placental microbiome and pediatric research." Pediatr Res. 2014 Sep;76(3):218-9. doi: 10.1038/pr.2014.95. Epub 2014 Jul 8. No abstract available.