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Kwang Sik Kim, M.D.

Photo of Dr. Kwang Sik Kim, M.D.

Director, Pediatric Infectious Diseases

Professor of Pediatrics

Male

Expertise: Infectious Diseases, Meningitis, Pediatric Infectious Disease, Septic Shock

Research Interests: central nervous sytem infection; sepsis

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410-614-0732
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410-464-6641
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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-614-0732

600 N. Wolfe Street
David Rubenstein Child Health Building
Baltimore, MD 21287 map
Phone: 410-614-3917
Fax: 410-614-1491

Background

Dr. Kwang Sik Kim is a professor of pediatrics at the Johns Hopkins University School of Medicine. Dr. Kim serves as the director of the Eudowood Division of Pediatric Infectious Diseases at the Johns Hopkins Children’s Center. He holds a joint appointment in molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health.

As a researcher, his chief interest is in the pathogenesis of sepsis and central nervous system (CNS) infections, using microbial genomics and proteomics. Sepsis and CNS infections are prevalent and remain the major causes of mortality and morbidity throughout the world; attempts to control such diseases have been hampered by incomplete knowledge of the pathogenesis. Dr. Kim’s group is the first to show, using E. coli, how bacteria translocate from blood to the CNS. His group is also one of the first to show that endotoxin requires soluble CD14 for activating endothelial cells. His continued investigations of microbes-host interactions pertaining to pathogenesis will lead to development of novel strategies (e.g., vaccines) to prevent sepsis and CNS infections.

Dr. Kim received his medical degree in 1971 from the Seoul National University in Korea. After serving three years in the Korean Air Force, he trained in pediatrics at Ellis Hospital in New York and Louisiana State University Division, Charity Hospital of Louisiana. A former fellow in pediatric infectious diseases at Harbor-UCLA Medical Center, UCLA School of Medicine, he left his post there as director of infectious diseases to join Johns Hopkins in 2000 as director of pediatric infectious diseases. At Johns Hopkins, he holds a joint appointment in molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health.

He has authored 250 peer-reviewed publications and has received several major awards, including the NIH's Fogarty Senior International Fellowship. He is a member of the American Association for the Advancement of Science, the Infectious Diseases Society of America, and the American Pediatric Society, among others.

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Titles

  • Director, Pediatric Infectious Diseases
  • Professor of Pediatrics

Departments / Divisions

Education

Degrees

  • MD, Seoul National University College of Medicine (1971)

Residencies

  • Medical Center of Louisiana at New Orleans-LSU Div / Pediatrics (1978)

Fellowships

  • Los Angeles County-Harbor-UCLA Medical Center / Pediatric Infectious Diseases (1980)

Board Certifications

  • American Board of Pediatrics / Pediatric Infectious Diseases (1994, 2008)
  • American Board of Pediatrics / Pediatrics (1979)

Research & Publications

Research Summary

Dr. Kim’s chief research interest is in the pathogenesis of sepsis and central nervous system (CNS) infections, using microbial genomics and proteomics. Sepsis and CNS infections are prevalent and remain the major causes of mortality and morbidity throughout the world; attempts to control such diseases have been hampered by incomplete knowledge of the pathogenesis. Dr. Kim’s group is the first to show, using E. coli, how bacteria translocate from blood to the CNS. His group is also one of the first to show that endotoxin requires soluble CD14 for activating endothelial cells. His continued investigations of microbes-host interactions pertaining to pathogenesis will lead to development of novel strategies (e.g., vaccines) to prevent sepsis and CNS infections.

Clinical Trial Keywords

antimicrobial agents, vaccines

Selected Publications

View all on Pubmed

Agostoni C, Kim KS. "Nutrition and the microbiome 2015." Pediatr Res. 2015 Jan;77(1-2):113-4. doi: 10.1038/pr.2014.195.

Kumar G, Date OS, Kim KS, Manjunath R. "Infection of human amniotic and endothelial cells by Japanese encephalitis virus: Increased expression of HLA-F." Virology. 2014 Dec;471-473:29-37. doi: 10.1016/j.virol.2014.09.022. Epub 2014 Oct 20.

Tan YC, Gill AK, Kim KS. "Treatment strategies for central nervous system infections: an update." Expert Opin Pharmacother. 2015 Feb;16(2):187-203. doi: 10.1517/14656566.2015.973851. Epub 2014 Oct 18.

Kim MJ, Yang KW, Kim SS, Park SM, Park KJ, Kim KS, Choi YH, Cho KK, Hyun CG. "Chemical composition and anti-inflammation activity of essential oils from Citrus unshiu flower." Nat Prod Commun. 2014 May;9(5):727-30.

Tarazi C, Agostoni C, Kim KS. "The placental microbiome and pediatric research." Pediatr Res. 2014 Sep;76(3):218-9. doi: 10.1038/pr.2014.95. Epub 2014 Jul 8. No abstract available.

Activities & Honors

Honors

  • Fogarty Senior International Fellowship, National Institutes of Health

Memberships

  • American Association for the Advancement of Science
  • Infectious Diseases Society of America
  • American Pediatric Society
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