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Michael Gilbert Goggins, M.B.B.Ch., M.D.

Photo of Dr. Michael Gilbert Goggins, M.B.B.Ch., M.D.

Professor of Pathology

Male

Expertise: Abdominal Pain, Bloating, Burping, Belching, Cancer, Celiac Disease, Chest Pain, Clinical Gastroenterology, Colon Polyps, Constipation, Diarrhea, Digestive Diseases, Diverticulitis, Diverticulosis, Eosinophilic Esophagitis, Family History of Cancer, Gallbladder Disorders, Gallstones, Gas, Gastroenterology, Heartburn, Hiccups, Hoarseness, Indigestion, Irritable Bowel Syndrome, Malabsorption, Nausea, Pancreatic Cancer, Pancreatic Disease, Peptic Ulcer, Rectal Bleeding, Rectal Problem, Reflux and Burning, Reflux Esophagitis, Stomach Pain, Stomach Ulcer, Swallowing Disorders, Vomiting, Weight Loss ...read more

Research Interests: Early detection of pancreatic cancer; markers of pancreatic cancer; pancreatic cancer screening; familial pancreatic cancer; pancreatic cancer epigenetics; pancreatic cancer genetics ...read more

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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-933-7495

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Community Physicians - Green Spring Station
Appointment Phone: 410-616-7350

2360 W. Joppa Road
Joppa Concourse
Lutherville, MD 21093 map

Johns Hopkins Medicine - Green Spring Station
Appointment Phone: 410-583-2888

Green Spring Station
10755 Falls Road
Pavilion I
Lutherville, MD 21093 map

Background

Dr. Michael G. Goggins is a professor of pathology, medicine and oncology at the Johns Hopkins University School of Medicine. He serves as director of the Pancreatic Cancer Early Detection Laboratory and is an attending physician in medicine in the Division of Gastroenterology and Hepatology at The Johns Hopkins Hospital, as well as a molecular biologist.

Dr. Goggins’ research interests include the role of germline BRCA2 mutations in pancreas cancer and characterizing the molecular genetic progression model for pancreas cancer.

He obtained his medical degree in 1988 from Trinity College of the University of Dublin, Ireland. He completed a residency in internal medicine and a fellowship in Gastroenterology at St. James' Hospital in Dublin. He obtained his Membership of the Royal College of Physicians of Ireland in 1991 and his European Diploma in Gastroenterology in 1995. He joined the Johns Hopkins faculty in 1999.

Dr. Goggins is a member of the Royal College of Physicians and the European Board of Gastroenterology. He sits on the editorial boards of Gut, Clinical Gastroenterology and Hepatology, and Cancer Biology and Therapy.

...read more

Titles

  • Professor of Pathology
  • Professor of Medicine
  • Professor of Oncology

Education

Degrees

  • MD, University of Dublin Trinity College (1988)

Residencies

  • St James's Hospital (1989)
  • St James's Hospital / Medicine (1991)

Fellowships

  • St James's Hospital / Internal Medicine (1995)
  • Johns Hopkins University School of Medicine (1998)

Research & Publications

Research Summary

Dr. Goggins’ current research is focused on discovering new markers of pancreatic adenocarcinoma using genetic, epigenetic and proteomic strategies, characterizing the epigenetic alterations in pancreatic cancers and normal tissues and identifying familial pancreatic cancer susceptibility genes through linkage, genome wide association and candidate gene approaches. Additional epigenetic studies are aimed at determining the functional and clinical significance of aberrant DNA methylation changes in pancreatic cancers.

Lab

In the Pancreatic Cancer Early Detection Laboratory, Dr. Goggins oversees research that focuses on gene expression patterns of pancreatic cancers using microarray technology. The lab is also studying DNA methylation patterns looking for genes that are methylated in pancreatic cancer but not in normal cells.

The lab has put together a profile of genes that are methylated in pancreatic cancer. Some pancreatic cancers methylate a lot of genes; most appear to methylate only a few genes. The lab is currently directing efforts to identify additional genes methylated in pancreatic cancer using novel techniques, and is studying the role of telomerase in pancreatic cancer and its potential as a marker for early detection.

Clinical Trials

The Cancer of the Pancreas Screening-5 CAPS5)Study

http://clinicaltrials.gov/show/NCT02000089

Selected Publications

Yu J, Blackford A, Dal Molin M, Wolfgang C, Goggins M. Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut 2015;epub Jan31. PMC4520782

Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M. KRAS and GNAS Mutations in Pancreatic Juice Collected From the Duodenum of Patients at High Risk for Neoplasia Undergoing Endoscopic Ultrasound. Clin Gastroenterol Hepatol 2015;13:963-9. PMC4404180.

Sadakari Y, Kanda M, Maitani K, Borges M, Canto MI, Goggins M. Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen. Clin Transl Gastroenterol 2014;in press. PMCID in process

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, Van Seuningen I, Maitra A, Goggins M. Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. Oncotarget 2014; 5:2575-2587. PMC4058028

Kim H, Saka B, Knight S, Borges M, Childs E, Klein AP, Wolfgang CL, Herman JM, Adsay V, Hruban RH, Goggins M. Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis. Clin Cancer Res 2014;20: 1865-72 PMC3975663

Academic Affiliations & Courses

Graduate Program Affiliation

Pathology

Pathobiology

Activities & Honors

Memberships

  • European Board of Gastroenterology
  • Royal College of Physicians of Ireland

Professional Activities

  • Ad hoc reviewer, Deafness Research Foundation, 2010
  • Ad hoc reviewer, Human Frontiers Science Program, 2010
  • Ad hoc reviewer, NIH Molecular, Cellular, and Developmental Neuroscience (MDCN) Special Emphasis Panel, 2013
  • Ad hoc reviewer, Communication Disorders Review Committee (CDRC) of the National Institute on Deafness and¬†Communication Disorders (NIDCD), 2013 - 2014
  • Ad hoc reviewer, Neurological Foundation New Zealand, 2013
  • Invited international reviewer, Deutsche Forschungs Gemeinschaft (DFG), Germany, 2014
  • NIH NIDCD, ad hoc reviewer, 2004
    RO3 study section
  • Publications Committee, Association for Research in Otolaryngology, 2014
  • Ad hoc reviewer, The Wellcome Trust, UK, 1998 - 2013
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