Skip Navigation
Search Menu
Find an Expert

 


Michael Gilbert Goggins, M.B.B.Ch., M.D.

Photo of Dr. Michael Gilbert Goggins, M.B.B.Ch., M.D.

Professor of Pathology

Male

Expertise: Abdominal Pain, Bloating, Burping, Belching, Cancer, Celiac Disease, Chest Pain, Clinical Gastroenterology, Colon Polyps, Constipation, Diarrhea, Digestive Diseases, Diverticulitis, Diverticulosis, Eosinophilic Esophagitis, Family History of Cancer, Gallbladder Disorders, Gallstones, Gas, Gastroenterology, Heartburn, Hiccups, Hoarseness, Indigestion, Irritable Bowel Syndrome, Malabsorption, Nausea, Pancreatic Cancer, Pancreatic Disease, Peptic Ulcer, Rectal Bleeding, Rectal Problem, Reflux and Burning, Reflux Esophagitis, Stomach Pain, Stomach Ulcer, Swallowing Disorders, Vomiting, Weight Loss ...read more

Research Interests: Early detection of pancreatic cancer; markers of pancreatic cancer; pancreatic cancer screening; familial pancreatic cancer; pancreatic cancer epigenetics; pancreatic cancer genetics ...read more

Request an Appointment

I live in Maryland

410-933-7495
Request an appointment through MyChart!

I live outside of Maryland

410-464-6641
Request Appointment

I live outside of the United States

+1-410-502-7683
Request Appointment

Locations

The Johns Hopkins Hospital
Appointment Phone: 410-933-7495

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Community Physicians - Green Spring Station
Appointment Phone: 410-616-7350

2360 W. Joppa Road
Joppa Concourse
Lutherville, MD 21093 map

Johns Hopkins Medicine - Green Spring Station
Appointment Phone: 410-583-2888

Green Spring Station
10755 Falls Road
Pavilion I
Lutherville, MD 21093 map

Background

Dr. Michael G. Goggins is a professor of pathology, medicine and oncology at the Johns Hopkins University School of Medicine. He serves as director of the Pancreatic Cancer Early Detection Laboratory and is an attending physician in medicine in the Division of Gastroenterology and Hepatology at The Johns Hopkins Hospital, as well as a molecular biologist.

Dr. Goggins’ research interests include the role of germline BRCA2 mutations in pancreas cancer and characterizing the molecular genetic progression model for pancreas cancer.

He obtained his medical degree in 1988 from Trinity College of the University of Dublin, Ireland. He completed a residency in internal medicine and a fellowship in Gastroenterology at St. James' Hospital in Dublin. He obtained his Membership of the Royal College of Physicians of Ireland in 1991 and his European Diploma in Gastroenterology in 1995. He joined the Johns Hopkins faculty in 1999.

Dr. Goggins is a member of the Royal College of Physicians and the European Board of Gastroenterology. He sits on the editorial boards of Gut, Clinical Gastroenterology and Hepatology, and Cancer Biology and Therapy.

...read more

Titles

  • Professor of Pathology
  • Professor of Medicine
  • Professor of Oncology

Education

Degrees

  • MD, University of Dublin Trinity College (1988)

Residencies

  • St James's Hospital (1989)
  • St James's Hospital / Medicine (1991)

Fellowships

  • St James's Hospital / Internal Medicine (1995)
  • Johns Hopkins University School of Medicine (1998)

Research & Publications

Research Summary

Dr. Goggins’ current research is focused on discovering new markers of pancreatic adenocarcinoma using genetic, epigenetic and proteomic strategies, characterizing the epigenetic alterations in pancreatic cancers and normal tissues and identifying familial pancreatic cancer susceptibility genes through linkage, genome wide association and candidate gene approaches. Additional epigenetic studies are aimed at determining the functional and clinical significance of aberrant DNA methylation changes in pancreatic cancers.

Lab

In the Pancreatic Cancer Early Detection Laboratory, Dr. Goggins oversees research that focuses on gene expression patterns of pancreatic cancers using microarray technology. The lab is also studying DNA methylation patterns looking for genes that are methylated in pancreatic cancer but not in normal cells.

The lab has put together a profile of genes that are methylated in pancreatic cancer. Some pancreatic cancers methylate a lot of genes; most appear to methylate only a few genes. The lab is currently directing efforts to identify additional genes methylated in pancreatic cancer using novel techniques, and is studying the role of telomerase in pancreatic cancer and its potential as a marker for early detection.

Clinical Trials

The Cancer of the Pancreas Screening-5 CAPS5)Study

http://clinicaltrials.gov/show/NCT02000089

Selected Publications

  1. Canto, M.I.; Goggins, M.; Hruban, R.H.; Petersen, G.M.; Giardiello, F.M.; Yeo, C.; Fishman, E.K.; Brune, K.; Axilbund, J.; Griffin, C.; Ali, S.; Richman, J.; Jagannath, S.; Kantsevoy, S.V.; Kalloo, A.N. Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol. 2006 Jun;4(6):766-781; quiz 665.
  2. Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Kamiyama, H.; Jimeno, A.; Hong, S.M.; Fu, B.; Lin, M.T.; Calhoun, E.S.; Kamiyama, M.; Walter, K.; Nikolskaya, T.; Nikolsky, Y.; Hartigan, J.; Smith, D.R.; Hidalgo, M.; Leach, S.D.; Klein, A.P.; Jaffee, E.M.; Goggins, M.; Maitra, A.; Iacobuzio-Donahue, C.; Eshleman, J.R.; Kern, S.E.; Hruban, R.H.; Karchin, R.; Papadopoulos, N.; Parmigiani, G.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26;321(5897):1801-1806.
  3. Axilbund, J.E.; Argani, P.; Kamiyama, M.; Palmisano, E.; Raben, M.; Borges, M.; Brune, K.A.; Goggins, M.; Hruban, R.H.; Klein, A.P. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. Cancer Biol Ther. 2009 Jan;8(2):131-135.
  4. Blackford, A.; Parmigiani, G.; Kensler, T.W.; Wolfgang, C.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Klein, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W.; Hruban, R.H. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15;69(8):3681-3688.
  5. Blackford, A.; Serrano, O.K.; Wolfgang, C.L.; Parmigiani, G.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Herman, J.M.; Laheru, D.; Klein, A.P.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Hruban, R.H. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15;15(14):4674-4679.
  6. Jones, S.; Hruban, R.H.; Kamiyama, M.; Borges, M.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Palmisano, E.; Brune, K.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Parmigiani, G.; Kern, S.E.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Eshleman, J.R.; Goggins, M.; Klein, A.P. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10;324(5924):217.
  7. Koorstra, J.B.; Hong, S.M.; Shi, C.; Meeker, A.K.; Ryu, J.K.; Offerhaus, G.J.; Goggins, M.G.; Hruban, R.H.; Maitra, A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod Pathol. 2009 Nov;22(11):1439-1445.
  8. Shi, C.; Chandrasekaran, A.; Thuluvath, P.J.; Karikari, C.; Argani, P.; Goggins, M.; Maitra, A.; Eshleman, J.R. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn. 2009 Nov;11(6):583-589.
  9. Wang, L.; Brune, K.A.; Visvanathan, K.; Laheru, D.; Herman, J.; Wolfgang, C.; Schulick, R.; Cameron, J.L.; Goggins, M.; Hruban, R.H.; Klein, A.P. Elevated cancer mortality in the relatives of patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2829-2834.
  10. Bisht, S.; Mizuma, M.; Feldmann, G.; Ottenhof, N.A.; Hong, S.M.; Pramanik, D.; Chenna, V.; Karikari, C.; Sharma, R.; Goggins, M.G.; Rudek, M.A.; Ravi, R.; Maitra, A. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther. 2010 Aug;9(8):2255-2264.
  11. Brune, K.A.; Lau, B.; Palmisano, E.; Canto, M.; Goggins, M.G.; Hruban, R.H.; Klein, A.P. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst. 2010 Jan 20;102(2):119-126.
  12. De Jong, M.C.; Hong, S.M.; Augustine, M.M.; Goggins, M.; Wolfgang, C.L.; Hirose, K.; Schulick, R.; Choi, M.; Anders, R.; Pawlik, T.M. Proximal cholangiocarcinoma: Tumor Depth Predicts Outcome. Arch Surg. 2010;In Press.
  13. Feldmann, G.; Mishra, A.; Hong, S.M.; Bisht, S.; Strock, C.J.; Ball, D.W.; Goggins, M.; Maitra, A.; Nelkin, B.D. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. Cancer Res. 2010 Jun 1;70(11):4460-4469.
  14. Gold, D.V.; Goggins, M.; Modrak, D.E.; Newsome, G.; Liu, M.; Shi, C.; Hruban, R.H.; Goldenberg, D.M. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2786-2794.
  15. Gurel, B.; Ali, T.Z.; Montgomery, E.A.; Begum, S.; Hicks, J.; Goggins, M.; Eberhart, C.G.; Clark, D.P.; Bieberich, C.J.; Epstein, J.I.; De Marzo, A.M. NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol. 2010 Aug;34(8):1097-1105.
  16. Harinck, F.; Canto, M.I.; Schulick, R.; Goggins, M.; Poley, J.W.; Fockens, P.; Kluijt, I.; Bruno, M. Surveillance in individuals at high risk of pancreatic cancer: too early to tell? Gut. 2010 Jul;59(7):1005; author reply 1006-1007.
  17. Hong, S.M.; Heaphy, C.M.; Shi, C.; Eo, S.H.; Cho, H.; Meeker, A.K.; Eshleman, J.R.; Hruban, R.H.; Goggins, M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol. 2010 Sep 24.
  18. Hruban, R.H.; Canto, M.I.; Goggins, M.; Schulick, R.; Klein, A.P. Update on familial pancreatic cancer. Adv Surg. 2010;44:293-311.
  19. Kamiyama, H.; Kamiyama, M.; Hong, S.M.; Karikari, C.A.; Lin, M.T.; Borges, M.W.; Griffith, M.; Young, A.; Norris-Kirby, A.; Lubek, C.; Mizuma, M.; Feldmann, G.; Shi, C.; Liang, H.; Goggins, M.G.; Maitra, A.; Hruban, R.H.; Eshleman, J.R. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest. 2010 May;90(5):665-673.
  20. Lennon, A.M.; Klein, A.P.; Goggins, M. ABO blood group and other genetic variants associated with pancreatic cancer. Genome Med. 2010;2(6):39.
  21. Omura, N.; Griffith, M.; Vincent, A.; Li, A.; Hong, S.M.; Walter, K.; Borges, M.; Goggins, M. Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins. Mol Cancer Res. 2010 Jun;8(6):821-832.
  22. Park, J.Y.; S-M., H.; Klimstra, D.S.; Goggins, M.G.; Maitra, A.; Hruban, R.H. Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms. Applied Immunohistochemistry & Molecular Morphology. 2010;In Press.
  23. Petersen, G.M.; Amundadottir, L.; Fuchs, C.S.; Kraft, P.; Stolzenberg-Solomon, R.Z.; Jacobs, K.B.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E.A.; Jacobs, E.J.; Klein, A.P.; LaCroix, A.; Li, D.; Mandelson, M.T.; Olson, S.H.; Risch, H.A.; Zheng, W.; Albanes, D.; Bamlet, W.R.; Berg, C.D.; Boutron-Ruault, M.C.; Buring, J.E.; Bracci, P.M.; Canzian, F.; Clipp, S.; Cotterchio, M.; de Andrade, M.; Duell, E.J.; Gaziano, J.M.; Giovannucci, E.L.; Goggins, M.; Hallmans, G.; Hankinson, S.E.; Hassan, M.; Howard, B.; Hunter, D.J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R.C.; Lynch, S.M.; McWilliams, R.R.; Mendelsohn, J.B.; Michaud, D.S.; Parikh, H.; Patel, A.V.; Peeters, P.H.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X.O.; Thomas, G.; Tjonneland, A.; Tobias, G.S.; Trichopoulos, D.; Van Den Eeden, S.K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B.M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J.F., Jr.; Hoover, R.N.; Hartge, P.; Chanock, S.J. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-228.
  24. Rasheed, Z.A.; Yang, J.; Wang, Q.; Kowalski, J.; Freed, I.; Murter, C.; Hong, S.M.; Koorstra, J.B.; Rajeshkumar, N.V.; He, X.; Goggins, M.; Iacobuzio-Donahue, C.; Berman, D.M.; Laheru, D.; Jimeno, A.; Hidalgo, M.; Maitra, A.; Matsui, W. Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst. 2010 Mar 3;102(5):340-351.
  25. Ryu, J.K.; Hong, S.M.; Karikari, C.A.; Hruban, R.H.; Goggins, M.G.; Maitra, A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology. 2010;10(1):66-73.

Yu J, Blackford A, Dal Molin M, Wolfgang C, Goggins M. Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut 2015;epub Jan31. PMC4520782

Eshleman JR, Norris AL, Sadakari Y, Debeljak M, Borges M, Harrington C, Lin E, Brant A, Barkley T, Almario JA, Topazian M, Farrell J, Syngal S, Lee JH, Yu J, Hruban RH, Kanda M, Canto MI, Goggins M. KRAS and GNAS Mutations in Pancreatic Juice Collected From the Duodenum of Patients at High Risk for Neoplasia Undergoing Endoscopic Ultrasound. Clin Gastroenterol Hepatol 2015;13:963-9. PMC4404180.

Sadakari Y, Kanda M, Maitani K, Borges M, Canto MI, Goggins M. Mutant KRAS and GNAS DNA Concentrations in Secretin-Stimulated Pancreatic Fluid Collected from the Pancreatic Duct and the Duodenal Lumen. Clin Transl Gastroenterol 2014;in press. PMCID in process

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, Van Seuningen I, Maitra A, Goggins M. Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth. Oncotarget 2014; 5:2575-2587. PMC4058028

Kim H, Saka B, Knight S, Borges M, Childs E, Klein AP, Wolfgang CL, Herman JM, Adsay V, Hruban RH, Goggins M. Having pancreatic cancer with tumoral loss of ATM and normal TP53 protein expression is associated with a poorer prognosis. Clin Cancer Res 2014;20: 1865-72 PMC3975663

Li A, Yu J, Kim H, Wolfgang CL, Canto MI, Hruban RH, Goggins M. MicroRNA array analysis finds elevated serum miR-1290 accurately distinguishes patients with low-stage pancreatic cancer from healthy and disease controls. Clin Cancer Res 2013;19:3600-3610 PMC3707520

Kanda M, Sadakari Y, Borges M, Topazian M, Farrell J, Syngal S, Lee J, Kamel I, Lennon AM, Knight S, Fujiwara S, Hruban RH, Canto MI, Goggins M. Mutant TP53 in Duodenal Samples of Pancreatic Juice from Patients with Pancreatic Cancer or High-Grade Dysplasia. Clin Gastroenterol Hepatol 2012:11:719-30 PMC3600161

Yu J, Li A, Hong SM, Hruban R, Goggins, M. MicroRNA Alterations of Pancreatic Intraepithelial Neoplasms (PanINs). Clin Cancer Res 2012; 8(4):981-92 PMC3288338

Amato E, Molin MD, Mafficini A, Yu J, Malleo G, Rusev B, Fassan M, Antonello D, Sadakari Y, Castelli P, Zamboni G, Maitra A, Salvia R, Hruban RH, Bassi C, Capelli P, Lawlor RT, Goggins M, Scarpa A. Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas. J Pathol 2014;233:217-227. PMC4057302

Kanda M, Matthaei H, Wu J, Hong SM, Yu J, Borges M, Hruban RH, Maitra A, Kinzler K, Vogelstein B, Goggins M. Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia. Gastroenterology 2012;142:730-733.e9. Epub 2012 Jan 5. PMC3321090

Canto MI, Hruban RH, Fishman EK, Kamel IR, Schulick R, Zhang Z, Topazian M, Takahashi N, Fletcher J, Petersen G, Klein AP, Axilbund J, Griffin C, Syngal S, Saltzman JR, Mortele KJ, Lee J, Tamm E, Vikram R, Bhosale P, Margolis D, Farrell J, Goggins M. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals. Gastroenterology 2012;142:796-804. PMC3321068

Kanda M, Knight S, Topazian M, Syngal S, Farrell JJ, Lee J, Kamel I, Lennon AM, Borges M, Young A, Fujiwara S, Seike J, Eshleman J, Hruban RH, Canto MI, Goggins M. Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts. Gut 2013;62:1024-33 PMC3893110

Hong SM, Vincent A, Kanda M, Leclerc J, Omura N, Borges M, Klein AP, Canto M, Hruban RH, Goggins M. Genome-wide somatic copy number alterations in low-Grade PanINs and IPMNs from individuals with a family history of Pancreatic Cancer. Clin Cancer Res 2012;18:4303-12.

Hong SM, Omura N, Vincent A, Li A, Knight S, Yu J, Hruban RH, Goggins M. Genome-wide CpG island profiling of intraductal papillary mucinous neoplasms of the pancreas. Clin Cancer Res 2012;18:700-12. PMC3271174

Vincent A, Omura N, Hong SM, Jaffe A, Eshleman J, Goggins M. Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma. Clin Cancer Res 2011;17:4341-54 PMC3131423

Goggins M. Markers of Pancreatic Cancer: Working Toward Early Detection. Clin Cancer Res 2011;17:635-7. PMC3079322

Hong SM, Heaphy CM, Shi C, Eo SH, Cho H, Meeker AK, Eshleman JR, Hruban RH, Goggins M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol 2011;24:256-66. PMC3166222

Hong SM, Li A, Olino K, Wolfgang CL, Herman JM, Schulick RD, Iacobuzio-Donahue C, Hruban RH, Goggins M. Loss of E-Cadherin Expression and Outcome among Patients with Resectable Pancreatic Adenocarcinomas. Mod Pathol 2011; 24(9):1237-47. PMC3155013

Li A, Omura N, Hong SM, Vincent A, Walter K, Griffith M, Borges M, Goggins M. Pancreatic cancers epigenetically silence SIP1, hypomethylate and overexpress miR-200a/-200b, in association with elevated circulating miR-200a and miR-200b levels. Cancer Research 2010; 70(13):5226-37 PMC3130565

Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M. Overexpression of Smoothened activates the Sonic Hedgehog signaling pathway in pancreatic cancer associated fibroblasts. Clin Cancer Res. 2010; 16:1781-9. PMCID: PMC2846609

Academic Affiliations & Courses

Graduate Program Affiliation

Pathology

Pathobiology

Activities & Honors

Memberships

  • European Board of Gastroenterology
  • Royal College of Physicians of Ireland

Professional Activities

  • Ad hoc reviewer, Deafness Research Foundation, 2010
  • Ad hoc reviewer, Human Frontiers Science Program, 2010
  • Ad hoc reviewer, NIH Molecular, Cellular, and Developmental Neuroscience (MDCN) Special Emphasis Panel, 2013
  • Ad hoc reviewer, Communication Disorders Review Committee (CDRC) of the National Institute on Deafness and Communication Disorders (NIDCD), 2013 - 2014
  • Ad hoc reviewer, Neurological Foundation New Zealand, 2013
  • Invited international reviewer, Deutsche Forschungs Gemeinschaft (DFG), Germany, 2014
  • NIH NIDCD, ad hoc reviewer, 2004
    RO3 study section
  • Publications Committee, Association for Research in Otolaryngology, 2014
  • Ad hoc reviewer, The Wellcome Trust, UK, 1998 - 2013
Is this you? Edit Profile