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Michael Gilbert Goggins, M.B.B.Ch., M.D.

Associate Professor of Pathology
Professor of Pathology

Male

Appointment Phone

410-933-7495

Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Associate Professor of Pathology
  • Professor of Pathology
  • Professor of Medicine
  • Professor of Oncology

Centers & Institutes

Departments

Locations

The Johns Hopkins Hospital

Appointment Phone: 410-933-7495

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map

Johns Hopkins Community Physicians - Green Spring Station

Appointment Phone: 410-616-7350

2360 W. Joppa Road
Joppa Concourse
Lutherville, MD 21093 map

Johns Hopkins Medicine - Green Spring Station

Appointment Phone: 410-583-2888

10755 Falls Road
Pavilion I
Lutherville, MD 21093 map

Expertise

Abdominal Pain, Bloating, Burping, Belching, Cancer, Celiac Disease, Chest Pain, Clinical Gastroenterology, Colon Polyps, Constipation, Diarrhea, Digestive Diseases, Diverticulitis, Eosinophilic Esophagitis, Gallbladder, Gallstones, Gas, Gastroenterology, Heartburn, Hiccups, Hoarseness, Indigestion, Irritable Bowel Syndrome, Malabsorption, Nausea, Pancreatic Cancer, Rectal Bleeding, Rectal Problem, Reflux and Burning, Stomach Pain, Stomach Ulcer, Swallowing Disorders, Vomiting, Weight Loss

Research Interests

Pancreatic cancer epigenetics; Pancreatic cancer genetics; Pancreatic cancer screening; Familial pancreatic cancer; Early detection of pancreatic cancer; Pancreatic cancer

Biography

Dr. Michael G. Goggins is a professor of pathology, medicine and oncology at the Johns Hopkins University School of Medicine. He serves as director of the Pancreatic Cancer Early Detection Laboratory and is an attending physician in medicine in the Division of Gastroenterology and Hepatology at The Johns Hopkins Hospital, as well as a molecular biologist.

Dr. Goggins’ research interests include the role of germline BRCA2 mutations in pancreas cancer and characterizing the molecular genetic progression model for pancreas cancer.

He obtained his medical degree in 1988 from Trinity College of the University of Dublin, Ireland. He completed a residency in internal medicine and a fellowship in Gastroenterology at St. James' Hospital in Dublin. He obtained his Membership of the Royal College of Physicians of Ireland in 1991 and his European Diploma in Gastroenterology in 1995. He joined the Johns Hopkins faculty in 1999.

Dr. Goggins is a member of the Royal College of Physicians and the European Board of Gastroenterology. He sits on the editorial boards of Gut, Clinical Gastroenterology and Hepatology, and Cancer Biology and Therapy.

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Featured Video

Hereditary Pancreatic Cancer - Q&A

    Additional Information

  • Education +

    Degrees

    • University of Dublin Trinity College / MD (1988)

    Residencies

    • St James's Hospital (1989)
    • St James's Hospital / Medicine (1991)

    Fellowships

    • St James's Hospital / Internal Medicine (1995)
    • Johns Hopkins University School of Medicine (1998)
  • Research & Publications +

    Research Summary

    Dr. Goggins’ current research is focused on discovering new markers of pancreatic adenocarcinoma using genetic, epigenetic and proteomic strategies, characterizing the epigenetic alterations in pancreatic cancers and normal tissues and identifying familial pancreatic cancer susceptibility genes through linkage, genome wide association and candidate gene approaches. Additional epigenetic studies are aimed at determining the functional and clinical significance of aberrant DNA methylation changes in pancreatic cancers.

    Lab:

    In the Pancreatic Cancer Early Detection Laboratory, Dr. Goggins oversees research that focuses on gene expression patterns of pancreatic cancers using microarray technology. The lab is also studying DNA methylation patterns looking for genes that are methylated in pancreatic cancer but not in normal cells.

    The lab has put together a profile of genes that are methylated in pancreatic cancer. Some pancreatic cancers methylate a lot of genes; most appear to methylate only a few genes. The lab is currently directing efforts to identify additional genes methylated in pancreatic cancer using novel techniques, and is studying the role of telomerase in pancreatic cancer and its potential as a marker for early detection.

    Clinical Trials:

    The Cancer of the Pancreas Screening-5 CAPS5)Study

    http://clinicaltrials.gov/show/NCT02000089


    Selected Publications

    1. Canto, M.I.; Goggins, M.; Hruban, R.H.; Petersen, G.M.; Giardiello, F.M.; Yeo, C.; Fishman, E.K.; Brune, K.; Axilbund, J.; Griffin, C.; Ali, S.; Richman, J.; Jagannath, S.; Kantsevoy, S.V.; Kalloo, A.N. Screening for early pancreatic neoplasia in high-risk individuals: a prospective controlled study. Clin Gastroenterol Hepatol. 2006 Jun;4(6):766-781; quiz 665.
    2. Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Kamiyama, H.; Jimeno, A.; Hong, S.M.; Fu, B.; Lin, M.T.; Calhoun, E.S.; Kamiyama, M.; Walter, K.; Nikolskaya, T.; Nikolsky, Y.; Hartigan, J.; Smith, D.R.; Hidalgo, M.; Leach, S.D.; Klein, A.P.; Jaffee, E.M.; Goggins, M.; Maitra, A.; Iacobuzio-Donahue, C.; Eshleman, J.R.; Kern, S.E.; Hruban, R.H.; Karchin, R.; Papadopoulos, N.; Parmigiani, G.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26;321(5897):1801-1806.
    3. Axilbund, J.E.; Argani, P.; Kamiyama, M.; Palmisano, E.; Raben, M.; Borges, M.; Brune, K.A.; Goggins, M.; Hruban, R.H.; Klein, A.P. Absence of germline BRCA1 mutations in familial pancreatic cancer patients. Cancer Biol Ther. 2009 Jan;8(2):131-135.
    4. Blackford, A.; Parmigiani, G.; Kensler, T.W.; Wolfgang, C.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Klein, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W.; Hruban, R.H. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15;69(8):3681-3688.
    5. Blackford, A.; Serrano, O.K.; Wolfgang, C.L.; Parmigiani, G.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Herman, J.M.; Laheru, D.; Klein, A.P.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Hruban, R.H. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15;15(14):4674-4679.
    6. Jones, S.; Hruban, R.H.; Kamiyama, M.; Borges, M.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Palmisano, E.; Brune, K.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Parmigiani, G.; Kern, S.E.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Eshleman, J.R.; Goggins, M.; Klein, A.P. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10;324(5924):217.
    7. Koorstra, J.B.; Hong, S.M.; Shi, C.; Meeker, A.K.; Ryu, J.K.; Offerhaus, G.J.; Goggins, M.G.; Hruban, R.H.; Maitra, A. Widespread activation of the DNA damage response in human pancreatic intraepithelial neoplasia. Mod Pathol. 2009 Nov;22(11):1439-1445.
    8. Shi, C.; Chandrasekaran, A.; Thuluvath, P.J.; Karikari, C.; Argani, P.; Goggins, M.; Maitra, A.; Eshleman, J.R. Ultrasensitive detection of KRAS2 mutations in bile and serum from patients with biliary tract carcinoma using LigAmp technology. J Mol Diagn. 2009 Nov;11(6):583-589.
    9. Wang, L.; Brune, K.A.; Visvanathan, K.; Laheru, D.; Herman, J.; Wolfgang, C.; Schulick, R.; Cameron, J.L.; Goggins, M.; Hruban, R.H.; Klein, A.P. Elevated cancer mortality in the relatives of patients with pancreatic cancer. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2829-2834.
    10. Bisht, S.; Mizuma, M.; Feldmann, G.; Ottenhof, N.A.; Hong, S.M.; Pramanik, D.; Chenna, V.; Karikari, C.; Sharma, R.; Goggins, M.G.; Rudek, M.A.; Ravi, R.; Maitra, A. Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther. 2010 Aug;9(8):2255-2264.
    11. Brune, K.A.; Lau, B.; Palmisano, E.; Canto, M.; Goggins, M.G.; Hruban, R.H.; Klein, A.P. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst. 2010 Jan 20;102(2):119-126.
    12. De Jong, M.C.; Hong, S.M.; Augustine, M.M.; Goggins, M.; Wolfgang, C.L.; Hirose, K.; Schulick, R.; Choi, M.; Anders, R.; Pawlik, T.M. Proximal cholangiocarcinoma: Tumor Depth Predicts Outcome. Arch Surg. 2010;In Press.
    13. Feldmann, G.; Mishra, A.; Hong, S.M.; Bisht, S.; Strock, C.J.; Ball, D.W.; Goggins, M.; Maitra, A.; Nelkin, B.D. Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling. Cancer Res. 2010 Jun 1;70(11):4460-4469.
    14. Gold, D.V.; Goggins, M.; Modrak, D.E.; Newsome, G.; Liu, M.; Shi, C.; Hruban, R.H.; Goldenberg, D.M. Detection of early-stage pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2010 Nov;19(11):2786-2794.
    15. Gurel, B.; Ali, T.Z.; Montgomery, E.A.; Begum, S.; Hicks, J.; Goggins, M.; Eberhart, C.G.; Clark, D.P.; Bieberich, C.J.; Epstein, J.I.; De Marzo, A.M. NKX3.1 as a marker of prostatic origin in metastatic tumors. Am J Surg Pathol. 2010 Aug;34(8):1097-1105.
    16. Harinck, F.; Canto, M.I.; Schulick, R.; Goggins, M.; Poley, J.W.; Fockens, P.; Kluijt, I.; Bruno, M. Surveillance in individuals at high risk of pancreatic cancer: too early to tell? Gut. 2010 Jul;59(7):1005; author reply 1006-1007.
    17. Hong, S.M.; Heaphy, C.M.; Shi, C.; Eo, S.H.; Cho, H.; Meeker, A.K.; Eshleman, J.R.; Hruban, R.H.; Goggins, M. Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. Mod Pathol. 2010 Sep 24.
    18. Hruban, R.H.; Canto, M.I.; Goggins, M.; Schulick, R.; Klein, A.P. Update on familial pancreatic cancer. Adv Surg. 2010;44:293-311.
    19. Kamiyama, H.; Kamiyama, M.; Hong, S.M.; Karikari, C.A.; Lin, M.T.; Borges, M.W.; Griffith, M.; Young, A.; Norris-Kirby, A.; Lubek, C.; Mizuma, M.; Feldmann, G.; Shi, C.; Liang, H.; Goggins, M.G.; Maitra, A.; Hruban, R.H.; Eshleman, J.R. In vivo and in vitro propagation of intraductal papillary mucinous neoplasms. Lab Invest. 2010 May;90(5):665-673.
    20. Lennon, A.M.; Klein, A.P.; Goggins, M. ABO blood group and other genetic variants associated with pancreatic cancer. Genome Med. 2010;2(6):39.
    21. Omura, N.; Griffith, M.; Vincent, A.; Li, A.; Hong, S.M.; Walter, K.; Borges, M.; Goggins, M. Cyclooxygenase-deficient pancreatic cancer cells use exogenous sources of prostaglandins. Mol Cancer Res. 2010 Jun;8(6):821-832.
    22. Park, J.Y.; S-M., H.; Klimstra, D.S.; Goggins, M.G.; Maitra, A.; Hruban, R.H. Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms. Applied Immunohistochemistry & Molecular Morphology. 2010;In Press.
    23. Petersen, G.M.; Amundadottir, L.; Fuchs, C.S.; Kraft, P.; Stolzenberg-Solomon, R.Z.; Jacobs, K.B.; Arslan, A.A.; Bueno-de-Mesquita, H.B.; Gallinger, S.; Gross, M.; Helzlsouer, K.; Holly, E.A.; Jacobs, E.J.; Klein, A.P.; LaCroix, A.; Li, D.; Mandelson, M.T.; Olson, S.H.; Risch, H.A.; Zheng, W.; Albanes, D.; Bamlet, W.R.; Berg, C.D.; Boutron-Ruault, M.C.; Buring, J.E.; Bracci, P.M.; Canzian, F.; Clipp, S.; Cotterchio, M.; de Andrade, M.; Duell, E.J.; Gaziano, J.M.; Giovannucci, E.L.; Goggins, M.; Hallmans, G.; Hankinson, S.E.; Hassan, M.; Howard, B.; Hunter, D.J.; Hutchinson, A.; Jenab, M.; Kaaks, R.; Kooperberg, C.; Krogh, V.; Kurtz, R.C.; Lynch, S.M.; McWilliams, R.R.; Mendelsohn, J.B.; Michaud, D.S.; Parikh, H.; Patel, A.V.; Peeters, P.H.; Rajkovic, A.; Riboli, E.; Rodriguez, L.; Seminara, D.; Shu, X.O.; Thomas, G.; Tjonneland, A.; Tobias, G.S.; Trichopoulos, D.; Van Den Eeden, S.K.; Virtamo, J.; Wactawski-Wende, J.; Wang, Z.; Wolpin, B.M.; Yu, H.; Yu, K.; Zeleniuch-Jacquotte, A.; Fraumeni, J.F., Jr.; Hoover, R.N.; Hartge, P.; Chanock, S.J. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010 Mar;42(3):224-228.
    24. Rasheed, Z.A.; Yang, J.; Wang, Q.; Kowalski, J.; Freed, I.; Murter, C.; Hong, S.M.; Koorstra, J.B.; Rajeshkumar, N.V.; He, X.; Goggins, M.; Iacobuzio-Donahue, C.; Berman, D.M.; Laheru, D.; Jimeno, A.; Hidalgo, M.; Maitra, A.; Matsui, W. Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst. 2010 Mar 3;102(5):340-351.
    25. Ryu, J.K.; Hong, S.M.; Karikari, C.A.; Hruban, R.H.; Goggins, M.G.; Maitra, A. Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology. 2010;10(1):66-73.
  • Academic Affiliations & Courses +

    Graduate Program Affiliation

    Pathology

    Pathobiology

  • Activities & Honors +

    Memberships

    • European Board of Gastroenterology
    • Royal College of Physicians of Ireland

    Professional Activities

    • Ad hoc reviewer, The Wellcome Trust, UK, 1998 - 2013
    • NIH NIDCD, ad hoc reviewer, 2004
      RO3 study section
    • Ad hoc reviewer, Deafness Research Foundation, 2010
    • Ad hoc reviewer, Human Frontiers Science Program, 2010
    • Ad hoc reviewer, NIH Molecular, Cellular, and Developmental Neuroscience (MDCN) Special Emphasis Panel, 2013
    • Ad hoc reviewer, Communication Disorders Review Committee (CDRC) of the National Institute on Deafness and¬†Communication Disorders (NIDCD), 2013 - 2014
    • Ad hoc reviewer, Neurological Foundation New Zealand, 2013
    • Invited international reviewer, Deutsche Forschungs Gemeinschaft (DFG), Germany, 2014
    • Publications Committee, Association for Research in Otolaryngology, 2014
  • Videos & Media +
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