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Thomas William Sedlak, M.D., Ph.D.

Photo of Dr. Thomas William Sedlak, M.D., Ph.D.

Director, Schizophrenia and Psychosis Consult Clinic

Assistant Professor of Psychiatry and Behavioral Sciences

Male

Expertise: Adult Psychiatry

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410-955-0424
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410-464-6641
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+1-410-502-7683
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Locations

The Johns Hopkins Hospital
Appointment Phone: 410-955-0424

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-614-6248

Johns Hopkins Bayview Medical Center
Appointment Phone: 410-614-6248

4940 Eastern Avenue
Baltimore, MD 21224 map
Phone: 410-614-6248

Background

Titles

  • Director, Schizophrenia and Psychosis Consult Clinic
  • Assistant Professor of Psychiatry and Behavioral Sciences

Departments / Divisions

Education

Degrees

  • MD PhD, Washington University School of Medicine (1999)

Residencies

  • Johns Hopkins University School of Medicine / Psychiatry (2003)

Fellowships

  • Johns Hopkins University School of Medicine / Psychiatry (2006)

Board Certifications

  • American Board of Psychiatry & Neurology / Psychiatry-General (2008)

Research & Publications

Research Summary

Our laboratory studies brain metabolic and antioxidant pathways relevant to normal brain biology and neuropsychiatric conditions such as schizophrenia and Alzheimer’s disease.

Lab

Our laboratory research:

Sedlak Lab

 

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Selected Publications

Saito, A., Taniguchi, Y., Rannals, M.D., Merfeld, E.B., Ballinger, M.D., Koga, M., Ohtani, Y., Gurley, D.A., Sedlak, T.W., Cross, A., et al. (2016). Early postnatal GABA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Mol Psychiatry. doi:10.1038/mp.2015.203

Sedlak, T.W., and Kaplin, A.I. (2016). Novel Neurotransmitters. In Kaplan & Sadock's Comprehensive Textbook of Psychiatry, 10th ed, B.J. Sadock, V.A. Sadock, and P. Ruiz, eds. (Philadelphia: Lippincott Williams & Wilkins).

Koga, M., Serritella, A.V., Sawa, A., and Sedlak, T.W. (2015). Implications for reactive oxygen species in schizophrenia pathogenesis. Schizophrenia Research. doi: 10.1016/j.schres.2015.06.022. [Epub ahead of print]

Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T.W., Korth, C., Brandon, N.J., et al. (2015). DISC1 regulates trafficking and processing of APP and Abeta generation. Mol Psychiatry 20, 874-879.

Tristan, C.A., Ramos, A., Shahani, N., Emiliani, F.E., Nakajima, H., Noeh, C.C., Kato, Y., Takeuchi, T., Noguchi, T., Kadowaki, H., et al. (2015). Role of Apoptosis Signal-regulating Kinase 1 (ASK1) as an Activator of the GAPDH-Siah1 Stress-Signaling Cascade. J Biol Chem 290, 56-64.

Kano, S., Yuan, M., Cardarelli, R.A., Maegawa, G., Higurashi, N., Gaval-Cruz, M., Wilson, A.M., Tristan, C., Kondo, M.A., Chen, Y., et al. (2015). Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy. Curr Mol Med 15, 138-145.

Emiliani, F.E., Sedlak, T.W., and Sawa, A. (2014). Oxidative stress and schizophrenia: recent breakthroughs from an old story. Curr Opin Psychiatry 27, 185-190.

Johnson, A.W., Jaaro-Peled, H., Shahani, N., Sedlak, T.W., Zoubovsky, S., Burruss, D., Emiliani, F., Sawa, A., and Gallagher, M. (2013). Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness. Proc Natl Acad Sci USA 110, 12462-12467.

Xu, R., Serritella, Anthony V., Sen, T., Farook, J.M., Sedlak, T.W., Baraban, J., Snyder, Solomon H., and Sen, N. (2013). Behavioral Effects of Cocaine Mediated by Nitric Oxide-GAPDH Transcriptional Signaling. Neuron 78, 623-630.

Koga, M., Serritella, A.V., Messmer, M.M., Hayashi-Takagi, A., Hester, L.D., Snyder, S.H., Sawa, A., and Sedlak, T.W. (2011). Glutathione is a physiologic reservoir of neuronal glutamate. Biochem Biophys Res Commun 409, 596-602.

Kamiya, A., Sedlak, T.W., and Pletnikov, M.V. (2012). DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders. Front Psychiatry 3, 1-7.

Tristan, C., Shahani, N., Sedlak, T.W., and Sawa, A. (2011). The diverse functions of GAPDH: views from different subcellular compartments. Cell Signal 23, 317-323.

Oveson, B.C., Iwase, T., Hackett, S.F., Lee, S.Y., Usui, S., Sedlak, T.W., Snyder, S.H., Campochiaro, P.A., and Sung, J.U. (2011). Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration. J Neurochem 116, 144-153.

Sedlak, T.W., Saleh, M., Higginson, D.S., Paul, B.D., Juluri, K.R., and Snyder, S.H. (2009). Bilirubin and glutathione have complementary antioxidant and cytoprotective roles. Proc Natl Acad Sci USA 106, 5171-5176.

Sedlak, T.W., and Kaplin, A.I. (2009). Novel Neurotransmitters. In Kaplan & Sadock's Comprehensive Textbook of Psychiatry, B.J. Sadock, V.A. Sadock, and P. Ruiz, eds. (Philadelphia: Lippincott Williams & Wilkins).

Sedlak, T.W., and Snyder, S.H. (2009). Cycling the wagons for biliverdin reductase. J Biol Chem 284, 11.

Sedlak, T.W., and Snyder, S.H. (2006). Messenger molecules and cell death: therapeutic implications. JAMA 295, 81-89.

Sedlak, T.W., and Snyder, S.H. (2004). Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle. Pediatrics 113, 1776-1782.

Boehning, D., Sedaghat, L., Sedlak, T.W., and Snyder, S.H. (2004). Heme oxygenase-2 is activated by calcium-calmodulin. J Biol Chem 279, 30927-30930.

Sedlak, T.W., Oltvai, Z.N., Yang, E., Wang, K., Boise, L.H., Thompson, C.B., and Korsmeyer, S.J. (1995). Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc Natl Acad Sci USA 92, 7834-7838.

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