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Photo of Dr. Clifford Mitsuo Takemoto, M.D.

Clifford Mitsuo Takemoto, M.D.

Associate Professor of Pediatrics


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Associate Professor of Pediatrics


  • Pathology
  • Pediatrics - Hematology


The Johns Hopkins Hospital

Appointment Phone: 410-955-6132

600 N. Wolfe Street
Sheikh Zayed Tower
Baltimore, MD 21287 map
Phone: 410-955-6132
Fax: 410-955-8208


Pediatric Hematology Oncology

Research Interests

Hemophilia; Sickle Cell Anemia; thrombosis; mast cells; bone marrow failure

    Additional Information

  • Education +


    • University of California (Irvine) School of Medicine / MD (1989)


    • Children's Hospital Los Angeles / Pediatrics (1992)


    • Dana-Farber Cancer Institute / Pediatric Hematology & Oncology (1996)
  • Research & Publications +

    Selected Publications

    Takemoto,C. and Fisher,D.E. (1995). Structural constraints for DNA recognition by Myc and other b-HLH-ZIP proteins: design of oncoprotein analogues. Gene Expr. 4, 311-317.

    Ewenstein,B.M., Takemoto,C., Warrier,I., Lusher,J., Saidi,P., Eisele,J., Ettinger,L.J., and DiMichele,D. (1997). Nephrotic syndrome as a complication of immune tolerance in hemophilia B. Blood 89, 1115-1116.

    Hemesath,T.J., Price,E.R., Takemoto,C., Badalian,T., and Fisher,D.E. (1998). MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes. Nature 391, 298-301.

    Weilbaecher,K.N., Hershey,C.L., Takemoto,C.M., Horstmann,M.A., Hemesath,T.J., Tashjian,A.H., and Fisher,D.E. (1998). Age-resolving osteopetrosis: a rat model implicating microphthalmia and the related transcription factor TFE3. J. Exp. Med. 187, 775-785.

    Dharnidharka,V.R., Takemoto,C., Ewenstein,B.M., Rosen,S., and Harris,H.W. (1998). Membranous glomerulonephritis and nephrosis post factor IX infusions in hemophilia B. Pediatr. Nephrol. 12, 654-657.

    Takeda,K., Takemoto,C., Kobayashi,I., Watanabe,A., Nobukuni,Y., Fisher,D.E., and Tachibana,M. (2000). Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance. Hum. Mol. Genet. 9, 125-132.

    Wu,M., Hemesath,T.J., Takemoto,C.M., Horstmann,M.A., Wells,A.G., Price,E.R., Fisher,D.Z., and Fisher,D.E. (2000). c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev. 14, 301-312.

    Weilbaecher,K.N., Motyckova,G., Huber,W.E., Takemoto,C.M., Hemesath,T.J., Xu,Y., Hershey,C.L., Dowland,N.R., Wells,A.G., and Fisher,D.E. (2001). Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice. Mol. Cell 8, 749-758.

    Takemoto,C.M., Yoon,Y.J., and Fisher,D.E. (2002). The identification and functional characterization of a novel mast cell isoform of the microphthalmia-associated transcription factor. J. Biol. Chem. 277, 30244-30252.

    Clauss,S.B., Manco-Johnson,M.J., Quivers,E., Takemoto,C., and Spevak,P.J. (2003). Primary antiphospholipid antibody syndrome and cardiac involvement in a child. Pediatr. Cardiol. 24, 292-294.

    Takemoto,C. (2005). Sickle cell disease: matters of the heart. Pediatr. Blood Cancer 45, 870-871.

    Shahlaee,A.H., Brandal,S., Lee,Y.N., Jie,C., and Takemoto,C.M. (2007). Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells. J. Immunol. 178, 378-388.

    Savage,W.J., Kickler,T.S., and Takemoto,C.M. (2007). Acquired coagulation factor inhibitors in children after topical bovine thrombin exposure. Pediatr. Blood Cancer 49, 1025-1029.

    Strouse,J.J., Takemoto,C.M., Keefer,J.R., Kato,G.J., and Casella,J.F. (2008). Corticosteroids and increased risk of readmission after acute chest syndrome in children with sickle cell disease. Pediatr. Blood Cancer 50, 1006-1012.

    Farrar,J.E., Nater,M., Caywood,E., McDevitt,M.A., Kowalski,J., Takemoto,C.M., Talbot,C.C., Jr., Meltzer,P., Esposito,D., Beggs,A.H., Schneider,H.E., Grabowska,A., Ball,S.E., Niewiadomska,E., Sieff,C.A., Vlachos,A., Atsidaftos,E., Ellis,S.R., Lipton,J.M., Gazda,H.T., and Arceci,R.J. (2008). Abnormalities of the large ribosomal subunit protein, Rpl35a, in Diamond-Blackfan anemia. Blood 112, 1582-1592.

    Gamper,C.J., Takemoto,C.M., Schowinsky,J., Borowitz,M.J., Horwitz,M.S., and Strouse,J.J. (2008). Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia. Pediatr. Blood Cancer 50, 1072-1075.

    Khan,J.U., Takemoto,C.M., Casella,J.F., Streiff,M.B., Nwankwo,I.J., and Kim,H.S. (2008). Catheter-directed thrombolysis of inferior vena cava thrombosis in a 13-day-old neonate and review of literature. Cardiovasc. Intervent. Radiol. 31 Suppl 2, S153-S160.

    Takemoto,C.M., Lee,Y.N., Jegga,A.G., Zablocki,D., Brandal,S., Shahlaee,A., Huang,S., Ye,Y., Gowrisankar,S., Huynh,J., and McDevitt,M.A. (2008). Mast cell transcriptional networks. Blood Cells Mol. Dis. 41, 82-90.

    Strouse,J.J., Tamma,P., Kickler,T.S., and Takemoto,C.M. (2009). D-dimer for the diagnosis of venous thromboembolism in children. Am. J. Hematol. 84, 62-63.

    Takemoto,C.M. (2009). Rituximab for ITP: a long-term fix? Pediatr. Blood Cancer 52, 155-156.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • American Association of Immunologists
    • American Society of Hematology
    • American Society of Pediatric Hematology/Oncology
  • Videos & Media +
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