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Photo of Dr. Joseph M Savitt, MD, PhD

Joseph M Savitt, MD, PhD

Director, Johns Hopkins Movement Disorder Fellowship Program
Assistant Professor of Neurology
Male
Appointment Phone

410-550-5624

Primary Location

Johns Hopkins Bayview Medical Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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Titles

  • Director, Johns Hopkins Movement Disorder Fellowship Program
  • Director, Johns Hopkins Ataxia Center
  • Assistant Professor of Neurology

Centers & Institutes

  • Ataxia Center
  • Parkinson's Disease and Movement Disorders Center

Expertise

Botulinum Toxin Injections, Cerebellar Ataxia, Dyskinesia, Dystonia, Movement Disorders, Neurology, Parkinson's Disease, Tremor

Research Interests

GDNF; Ubiquitin; Autophagy; Ataxia; Neurodegeneration; Movement Disorders

Languages

  • English

Memberships

ORGANIZATIONAL ACTIVITIES

Ad Hoc Journal Peer Review: J. Neuroscience (2006, 2008);
J. Neurochemistry (2007-2009)
Cleveland Clinic Journal of Medicine (2008)
BBA Molecular Basis of Disease (2008)
Molecular and Cellular Neuroscience (2009)

Grant Review: Michael J. Fox Community Fast Track Review committee 2006-2009.
Michael J. Fox Rapid Response Innovation Awards 2009.
Parkinsons disease Society UK 2007.
Parkinson Study Group Scientific Review Committee Term 2007-2010.

Professional Societies: Parkinsons Study Group (2005- present), member of the working group on genetics and environmental risk.
American Academy of Neurology (1998-present)-Member
movement disorder section member.
Movement Disorder Society (2002-present)-Member.
Society for Neuroscience (1994-present)-Member.
National Ataxia Foundation (2008-present)-Member.
A-team member Chesapeake Chapter- National Ataxia Foundation.

Awards

Clinical Trial Keywords

  • Neuroprotection
  • Botulinum Toxin Injection
  • Parkinson Disease

Additional Resources

Additional Resources +
  • Education +

    Training

    • University of Maryland School of Medicine
    • University of Maryland School of Medicine

    Residencies

    • Johns Hopkins Hospital (2001)

    Fellowships

    • Johns Hopkins Hospital (2003)

    Certifications

    • American Board of Psychiatry and Neurology (2002)
  • Research & Publications +

    Selected Publications

    Publications (peer-reviewed)
    1. Skofitsch G, Savitt JM, Jacobowitz DM. Suggestive Evidence for a Functional Unit between
    Mast Cells and Substance P Fibers in the Rat Diaphragm and Mesentery. Histochem. 1985; 82: 5-8.

    2. Skofitsch G, Zamir N, Helke CJ, Savitt JM, Jacobowitz DM. Corticotrophin Releasing Factor-Like Immunoreactivity in Sensory Ganglia and Capsaicin Sensitive Neurons of the Rat Central Nervous System: Colocalization with Other Neuropeptides. Peptides. 1985; 6: 307-318.

    3. Johannessen JN, Savitt JM, Markey CJ, Bacon JP, Weisz A, Hanselman DS, Markey SP. The Development of Amine Substituted Analogues of MPTP as Unique Tools for the Study of MPTP Toxicity and Parkinsons Disease. Life Sciences. 1987; 40: 697-704.

    4. Fishman PS, Savitt JM. Selective Localization by Neuroglia of Immunoglobulin G in Normal Mice. Journal of Neuropathology and Experimental Neurology. 1989; 48(2): 212-220.

    5. Fishman PS, Savitt JM. Transsynaptic Transfer of Retrogradely Transported Tetanus Protein-Peroxidase Conjugates. Experimental Neurology, 1989; 106: 197-203.

    6. Fishman PS, Savitt JM, Farrand DA. Enhanced CNS Uptake of Systemically Administered Proteins Though Conjugation with Tetanus C-Fragment. J. Neurol. Sci. 1990; 98: 311-325.

    7. Savitt JM, Trisler D, Hilt DC. Molecular Cloning of TOPAP: A Topographically Graded Protein in the Developing Chick Visual System. Neuron. 1995; 14: 253-261.

    8. Figueiredo DM, Hallewell RA, Chen LL, Fairweather NF, Dougan G, Savitt JM, Parks DA, Fishman PS. Delivery of Recombinant Tetanus-Superoxide Dismutase Proteins to Central Nervous System Neurons by Retrograde Axonal Transport. Experimental Neurology. 1997; 145: 546-54.

    9. Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci. 2004;101 (29):10744-9.

    10. Savitt JM, Jang SS, Mu W, Dawson VL, Dawson TM. Bcl-x is required for the proper development of the mouse substantia nigra. J. Neurosci. 2005; 25: 6721-6728.

    11. Von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion Body Formation and Neurodegeneration are Parkin-independent in a Mouse Model of Alpha-Synucleinopathy. J. Neurosci. 2006; 26(14):3685-3696

    12. Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease, molecules to medicine. J. Clin. Invest. (2006) 116: 1744-1754.

    13. Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 2006; 60(5):557-569.

    14. The NINDS NET-PD Investigators. A Randomized Clinical Trial of Coenzyme Q10 and GPI-1485 in Early Parkinson Disease. Neurology. 2007; 68(1): 20-8.

    15. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty, DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of non-peptidergic DRG neurons. Neuron. 2007; 54: 739-754.

    16. The Parkinson Study Group. The Mixed Lineage Kinase Inhibitor CEP-1347 Fails to Delay Disability in Early Parkinsons Disease. Neurology. 2007; 69:1480-1490

    17. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A; Parkinson Study Group PRECEPT Investigators, Hyson C, Gorbold E, Rudolph A, Kieburtz K, Fahn S, Gauger L, Goetz C, Seibyl J, Forrest M, Ondrasik J. Serum urate as a predictor of clinical and radiographic progression in Parkinsons disease. Arch Neurol 2008; 65(6) 716-23.

    18. Tsang AKH, Lee Y, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson, VL, Dawson TM, Chung, KK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson''s disease. PNAS. 2009 106(12) 4900-5.


  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    2005         American Parkinson Disease Association Cotzias Fellowship
    2003-5     Passano Physician-Scientist Award
    2003         Herbert Friedberg Parkinson Disease Fellowship
    2001        Preziosi Award for Clinical Excellence, chief resident in Neurology, Johns Hopkins
    1997        Balder Scholarship Award for Outstanding Academic Achievement
    1997         Summa cum Laude, University of Maryland School of Medicine
    1996         Alpha Omega Alpha Medical Honor Society
    1994         Phi Kappa Phi Honor Society
    1997         Lange Medical Publications Award
    1993-95    Medical Student Research Awards
    1986         National Deans List/ B.A. w/ distinction in all subjects, Cornell University.
    1982         Bausch and Lomb Science Award.

    Professional Activities

    PROFESSIONAL EXPERIENCE
    1984 Summer Researcher National Institute of Mental Health, NIH
    Advisor: David Jacobowitz, MD
    1985-86 Summer Researcher National Institute of Mental Health, NIH
    Advisor: Sanford Markey PhD
    1995 Research Consultant Baltimore VA/ Department of Neurology
    Advisor: Paul Fishman MD PhD
    2003-present: Assistant Professor of Neurology Johns Hopkins School of Medicine
    2003-present: Active Staff Johns Hopkins Hospital
    2003-present: Courtesy Staff Johns Hopkins Bayview Medical Center
    2008-present: Director Johns Hopkins Ataxia Center
    2008-present Director Movement Disorder Fellowship Program
    Johns Hopkins Department of Neurology
  • Videos & Media +
  • Upcoming Events +
  • Contact & Locations +

    Locations

    Johns Hopkins Bayview Medical Center
    4940 Eastern Avenue
    Baltimore, MD 21224
    Appointment Phone: 410-550-5624
    Location Map
    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Hospital Main Entrance - Sheikh Zayed Tower
    Baltimore, MD 21287
    Phone: 410-614-0577
    Appointment Phone: 410-614-0577
    Fax: 443-298-3933
    Location Map
    Johns Hopkins Outpatient Center
    601 N. Caroline Street
    Baltimore, MD 21287
    Appointment Phone: 410-955-6700
    Location Map

    Department/Division

    • Neurology - Movement Disorders

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