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Photo of Dr. Joseph M Savitt, M.D., Ph.D.

Joseph M Savitt, M.D., Ph.D.

Director, Johns Hopkins Movement Disorder Fellowship Program

Male

Appointment Phone

443-755-0030

Main Location

Parkinsons and Movement Disorders Center of Maryland

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Director, Johns Hopkins Movement Disorder Fellowship Program
  • Director, Johns Hopkins Ataxia Center

Centers & Institutes

Locations

Parkinsons and Movement Disorders Center of Maryland

Appointment Phone: 443-755-0030

8180 Lark Brown Road
Elkridge, MD 21075 map
Phone: 443-755-0030

Expertise

Botulinum Toxin Injections, Cerebellar Ataxia, Dyskinesia, Dystonia, Movement Disorders, Neurology, Parkinson's Disease , Tremor

Research Interests

Movement Disorders; Neurodegeneration; Ataxia; Ubiquitin; Autophagy; GDNF

    Additional Information

  • Education +

    Degrees

    • University of Maryland School of Medicine / Ph.D (1994)
    • University of Maryland School of Medicine / MD PhD (1997)

    Residencies

    • Johns Hopkins University School of Medicine / Neurology (2001)

    Fellowships

    • Johns Hopkins University School of Medicine / Neurology (2003)

    Certifications

    • American Board of Psychiatry & Neurology / Neurology (2002)
  • Research & Publications +

    Clinical Trial Keywords: Neuroprotection, Botulinum Toxin Injection, Parkinson Disease

    Selected Publications

    Publications (peer-reviewed)
    1. Skofitsch G, Savitt JM, Jacobowitz DM. Suggestive Evidence for a Functional Unit between
    Mast Cells and Substance P Fibers in the Rat Diaphragm and Mesentery. Histochem. 1985; 82: 5-8.

    2. Skofitsch G, Zamir N, Helke CJ, Savitt JM, Jacobowitz DM. Corticotrophin Releasing Factor-Like Immunoreactivity in Sensory Ganglia and Capsaicin Sensitive Neurons of the Rat Central Nervous System: Colocalization with Other Neuropeptides. Peptides. 1985; 6: 307-318.

    3. Johannessen JN, Savitt JM, Markey CJ, Bacon JP, Weisz A, Hanselman DS, Markey SP. The Development of Amine Substituted Analogues of MPTP as Unique Tools for the Study of MPTP Toxicity and Parkinsons Disease. Life Sciences. 1987; 40: 697-704.

    4. Fishman PS, Savitt JM. Selective Localization by Neuroglia of Immunoglobulin G in Normal Mice. Journal of Neuropathology and Experimental Neurology. 1989; 48(2): 212-220.

    5. Fishman PS, Savitt JM. Transsynaptic Transfer of Retrogradely Transported Tetanus Protein-Peroxidase Conjugates. Experimental Neurology, 1989; 106: 197-203.

    6. Fishman PS, Savitt JM, Farrand DA. Enhanced CNS Uptake of Systemically Administered Proteins Though Conjugation with Tetanus C-Fragment. J. Neurol. Sci. 1990; 98: 311-325.

    7. Savitt JM, Trisler D, Hilt DC. Molecular Cloning of TOPAP: A Topographically Graded Protein in the Developing Chick Visual System. Neuron. 1995; 14: 253-261.

    8. Figueiredo DM, Hallewell RA, Chen LL, Fairweather NF, Dougan G, Savitt JM, Parks DA, Fishman PS. Delivery of Recombinant Tetanus-Superoxide Dismutase Proteins to Central Nervous System Neurons by Retrograde Axonal Transport. Experimental Neurology. 1997; 145: 546-54.

    9. Von Coelln R, Thomas B, Savitt JM, Lim KL, Sasaki M, Hess EJ, Dawson VL, Dawson TM. Loss of locus coeruleus neurons and reduced startle in parkin null mice. Proc Natl Acad Sci. 2004;101 (29):10744-9.

    10. Savitt JM, Jang SS, Mu W, Dawson VL, Dawson TM. Bcl-x is required for the proper development of the mouse substantia nigra. J. Neurosci. 2005; 25: 6721-6728.

    11. Von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM. Inclusion Body Formation and Neurodegeneration are Parkin-independent in a Mouse Model of Alpha-Synucleinopathy. J. Neurosci. 2006; 26(14):3685-3696

    12. Savitt JM, Dawson VL, Dawson TM. Diagnosis and treatment of Parkinson disease, molecules to medicine. J. Clin. Invest. (2006) 116: 1744-1754.

    13. Biskup S, Moore DJ, Celsi F, Higashi S, West AB, Andrabi SA, Kurkinen K, Yu SW, Savitt JM, Waldvogel HJ, Faull RL, Emson PC, Torp R, Ottersen OP, Dawson TM, Dawson VL. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 2006; 60(5):557-569.

    14. The NINDS NET-PD Investigators. A Randomized Clinical Trial of Coenzyme Q10 and GPI-1485 in Early Parkinson Disease. Neurology. 2007; 68(1): 20-8.

    15. Luo W, Wickramasinghe SR, Savitt JM, Griffin JW, Dawson TM, Ginty, DD. A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of non-peptidergic DRG neurons. Neuron. 2007; 54: 739-754.

    16. The Parkinson Study Group. The Mixed Lineage Kinase Inhibitor CEP-1347 Fails to Delay Disability in Early Parkinsons Disease. Neurology. 2007; 69:1480-1490

    17. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A; Parkinson Study Group PRECEPT Investigators, Hyson C, Gorbold E, Rudolph A, Kieburtz K, Fahn S, Gauger L, Goetz C, Seibyl J, Forrest M, Ondrasik J. Serum urate as a predictor of clinical and radiographic progression in Parkinsons disease. Arch Neurol 2008; 65(6) 716-23.

    18. Tsang AKH, Lee Y, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson, VL, Dawson TM, Chung, KK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson''s disease. PNAS. 2009 106(12) 4900-5.


  • Academic Affiliations & Courses +
  • Activities & Honors +

    Honors

    • Bausch and Lomb Science Award, 1982
    • National Deans List/ B.A. w/ distinction in all subjects, Cornell University, 1986
    • Medical Student Research Awards, 1993 - 1995
    • Phi Kappa Phi, Honor Society, 1994
    • Alpha Omega Alpha, Medical Honor Society, 1996
    • Balder Scholarship Award for Outstanding Academic Achievement, 1997
    • Lange Medical Publications Award, 1997
    • Summa cum Laude, University of Maryland School of Medicine, 1997
    • Preziosi Award for Clinical Excellence, chief resident in Neurology, Johns Hopkins, 2001
    • Herbert Friedberg Parkinson Disease Fellowship, 2003
    • Passano Physician-Scientist Award, 2003 - 2005
    • American Parkinson Disease Association Cotzias Fellowship, 2005

    Memberships

    • Chesapeake Chapter- National Ataxia Foundation
      A-team member
    • Society for Neuroscience, 1994
      Member
    • American Academy of Neurology, 1998
      Member, movement disorder section member
    • Movement Disorder Society, 2002
      Member
    • Parkinsons Study Group, 2005
      member, working group on genetics and environmental risk
    • J. Neuroscience, 2006
      Ad Hoc Journal Peer Review
    • Michael J. Fox Community Fast Track Review committee, 2006 - 2009
      Grant Review
    • J. Neurochemistry, 2007 - 2009
      Ad Hoc Journal Peer Review
    • Parkinson Study Group Scientific Review Committee Term, 2007 - 2010
      Grant Review
    • Parkinsons disease Society UK, 2007
      Grant Review
    • BBA Molecular Basis of Disease, 2008
      Ad Hoc Journal Peer Review
    • Cleveland Clinic Journal of Medicine, 2008
      Ad Hoc Journal Peer Review
    • J. Neuroscience, 2008
      Ad Hoc Journal Peer Review
    • National Ataxia Foundation, 2008
      Member
    • Michael J. Fox Rapid Response Innovation Awards, 2009
      Grant Review
    • Molecular and Cellular Neuroscience, 2009
      Ad Hoc Journal Peer Review

    Professional Activities

    • Summer Researcher National Institute of Mental Health, NIH, 1984
    • Summer Researcher National Institute of Mental Health, NIH, 1985 - 1986
    • Director Johns Hopkins Ataxia Center, 2008
    • Director Movement Disorder Fellowship Program, 2008
  • Videos & Media +
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