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Alan Cheng, MD

Director, Arrhythmia Device Service
Associate Professor of Medicine
Male
Appointment Phone

443-997-0270

Main Location

The Johns Hopkins Hospital

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »

Titles

  • Director, Arrhythmia Device Service
  • Associate Professor of Medicine
  • Associate Professor of Pediatrics

Centers & Institutes

  • Atrial Fibrillation Center
  • Heart and Vascular Institute

Expertise

Ablation, Arrhythmia, Atrial Fibrillation, Atrial Flutter, Atrial Tachycardia, Biventricular Pacing, Bradycardia, Cardiac Catheterization, Cardiac Electrophysiology, Cardiology, Cardiovascular Computed Tomography, Cardiovascular Disease, Defibrillators, Electrophysiology, Event Monitors, Heart Disease, Holter Monitoring, Implantable Cardioverter-Defibrillator Therapy, Irregular Heartbeat, Pacemaker and ICD Lead Extraction, Pacemakers, Palpitations, Sarcoidosis, Stress Testing, Syncope, Tachycardias, Ventricular Arrhythmias, Ventricular Tachycardia

Research Interests

Cardiac Sarcoidosis; Pacemakers, ICDs and Cardiac Resynchronization Therapy; Atrial fibrillation Ablation; Sudden Cardiac Death

Languages

  • English
  • Chinese

Memberships

Fellow, American College of Cardiology
Fellow, American Heart Association
Fellow, Heart Rhythm Society

Clinical Trial Keywords

  • Cardiac Resynchronization Therapy
  • Sudden Cardiac Death
  • Sarcoidosis

Additional Resources

Additional Resources +
  • Education +

    Training

    • Yale University School of Medicine ( New Haven CT) (1998)

    Residencies

    • Johns Hopkins University School of Medicine / Internal Medicine ( Baltimore MD) (2001)

    Fellowships

    • Johns Hopkins University School of Medicine / Cardiology ( Baltimore MD) (2006)

    Certifications

    • American Board of Internal Medicine / Clinical Cardiac Electrophysiology (2007)
    • American Board of Internal Medicine / Cardiovascular Disease (2005)
  • Research & Publications +

    Selected Publications

    1. Chen M, Cheng A, Chen YQ, Hymel A, Hanson EP, Kimmel L, Minami Y, Taniguchi T, Changelian PS, OShea JJ. The Amino Terminus of JAK3 Is Necessary and Sufficient for Binding to the Common Gamma Chain and Confers the Ability to Transmit IL-2 Mediated Signals. Proc Natl Acad Sci USA 1997;94:6910-5.

    2. Cheng A, Scheinfeld NS, McDowell B, Dokras A. Warfarin Skin Necrosis In A Postpartum Woman With Protein S Deficiency. Obstet Gynecol 1997;90:671-2.

    3. Chen M, Cheng A, Candotti F, Zhou YJ, Hymel A, Fasth A, Notarangelo LD, OShea JJ. Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions Between the Kinase and Pseudokinase Domains. Mol Cell Bio 2000;20(3): 947-56.

    4. Ng CM, Cheng A, Myers LA, Martinez-Murillo F, Jie C, Bedja D, Gabrielson KL, Hausladen JMW, Mecham RP, Judge DP, Dietz HC. TGFβ-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. J Clin Invest 2004;114:1584-92.

    5. Piccini JP, Dalal D, Roguin A, Bomma C, Cheng A, Prakasa K, Dong J, Tichnell C, James C, Russell S, Crosson J, Marine JE, Tomaselli G, Calkins H. Predictors of Appropriate Implantable Defibrillator Therapies in Patients with Arrhythmogenic Right Ventricular Dysplasia. Heart Rhythm 2005;2:1188-94.

    6. Vasamreddy CR, Dalal D, Dong J, Cheng A, Spragg DD, Lamiy SZ, Meininger G, Henrikson CA, Marine JE, Berger R, Calkins H. Symptomatic and asymptomatic atrial fibrillation in patients undergoing radiofrequency catheter ablation. J Cardiovasc Electrophysiol 2006;17:134-9.

    7. Cheema A, Dong J, Dalal D, Vasamreddy CR, Marine JE, Henrikson CA, Spragg D, Cheng A, Nazarian S, Sinha S, Halperin H, Berger R, Calkins H.
    Long-Term Safety and Efficacy of Circumferential Ablation with Pulmonary Vein Isolation. J Cardiovasc Electrophysiol 2006;17:1080-5.

    8. Cheng A, Brinker JA, Reeves RC, Henrikson C. Novel Approach to Obtaining Vascular Access in Patients with Abandoned Endocardial Pacemaker and ICD Leads. J Cardiovasc Electrophysiol 2007;18(3):339-41.

    9. Cheng A, Calkins H. A Conservative Approach to Performing Transseptal Punctures Without The Use of Intracardiac Echocardiography: Stepwise Approach with Real-time Video Clips. J Cardiovasc Electrophysiol 2007;18(6):686-9.

    10. Henrikson CA, Spragg DD, Cheng A, Capps M, DeVaughn K, Marine JE, Calkins H, Tomaselli GF, Berger, RD. Evidence for Electrical Remodeling of the Native Conduction System with Cardiac Resynchronization Therapy. Pacing Clin Electrophysiol 2007;30:591-5.

    11. Schmidt A, Azevedo CF, Cheng A, Gupta SN, Bluemke DA, Foo TK, Gerstenblith G, Weiss RG, Marbn E, Tomaselli GF, Lima JAC, Wu KC. Infarct Tissue Heterogeneity By MRI Identifies Enhanced Cardiac Arrhythmia Susceptibility In Patients With Left Ventricular Dysfunction. Circulation 2007;115:2006-14.

    12. Cheema A, Dong J, Dalal D, Marine JE, Henrikson CA, Spragg D, Cheng A, Nazarian S, Bilchick KC, Almasry I, Sinha S, Scherr D, Halperin H, Berger R, Calkins H. Circumferential Ablation With Pulmonary Vein Isolation in Permanent Atrial Fibrillation. Am J Cardiol 2007;99:1425-8.

    13. Scherr D, Dalal D, Cheema A, Cheng A, Henrikson CA, Spragg D, Marine JE, Berger RD, Calkins H, Dong J. Automated Detection and Characterization of Complex Fractionated Atrial Electrograms in Human Left Atrium during Atrial Fibrillation. Heart Rhythm 2007;4:1013-20.

    14. Dong J, Dalal D, Scherr D, Cheema A, Nazarian S, Bilchick K, Almasry I, Cheng A, Henrikson C, Spragg D, Marine J, Berger R, Calkins H. Impact of Heart Rhythm Status on Registration Accuracy of the Left Atrium for Catheter Ablation of Atrial Fibrillation. J Cardiovasc Electrophysiol 2007;18:1269-76.

    15. Cheng A, Nazarian S, Spragg D, Bilchick K, Tandri H, Mark L, Halperin H, Calkins H, Berger RD, Henrikson C. Effects of Surgical and Endoscopic Electrocautery on Modern Day Permanent Pacemaker and Implantable Cardioverter-Defibrillator Systems. Pacing Clin Electrophysiol 2008;31:344-50.

    16. Spragg DD, Dalal D, Cheema A, Scherr D, Chilukuri K, Cheng A, Henrikson CA, Marine JE, Berger RD, Dong J, Calkins H. Complications of Catheter Ablation for Atrial Fibrillation: Incidence and Predictors. J Cardiovasc Electrophysiol 2008;19:627-31.

    17. Scherr D, Dalal D, Henrikson CA, Spragg DD, Berger RD, Calkins H, Cheng A. Prospective Comparison of the Diagnostic Utility of a Standard Event Monitor versus a Leadless Portable ECG Monitor in the Evaluation of Patients with Palpitations. J Interv Card Electrophysiol 2008;22:39-44.

    18. Scherr D, Dalal D, Cheema A, Nazarian S, Almasry I, Bilchick K, Cheng A, Henrikson C, Spragg D, Marine JE, Berger RD, Calkins H, Dong J. Long- And Short-Term Temporal Stability of Complex Fractionated Atrial Electrograms (CFAEs) in the Human Left Atrium during Atrial Fibrillation. J Cardiovasc Electrophysiol 2009;20:13-21.

    19. Berntsen RF, Cheng A, Calkins H, Berger RD. Evaluation of Spatiotemporal Organization of Longstanding Persistent Atrial Fibrillation with Time and Frequency Domain Measures in Human. Europace 2009;11:316-23.

    20. Chilukuri K, Scherr D, Dalal D, Henrikson CA, Marine JE, MacPherson EC, Cheng A, Spragg DD, Nazarian S, Sinha S, Berger RD, Calkins H. Incidence and Outcomes of Protamine Reactions in Patients Undergoing Catheter Ablation of Atrial Fibrillation. J Interv Card Electrophysiol 2009;25:175-81.

    21. Scherr D, Dalal D, Chilukuri K, Dong J, Spragg DD, Henrikson CA, Nazarian S, Cheng A, Berger RD, Abraham TP, Calkins H, Marine JE. Incidence and Predictors of Left Atrial Thombus Prior to Catheter Ablation of Atrial Fibrillation. J Cardiovasc Electrophysiol 2009;20:379-84.

    22. Chilukuri K, Dalal D, Marine JE, Scherr D, Henrikson CA, Cheng A, Nazarian S, Spragg DD, Berger RD, Calkins H. Predictive value of Obstructive Sleep Apnea assessed by the Berlin Questionnaire for outcomes after the catheter ablation of Atrial Fibrillation. Europace 2009;11:896-901.

    23. Cheng A, Dalal D, Fetics B, Angkeow P, Spragg DD, Calkins H, Tomaselli GF, Berger RD. Ibutilide-induced changes in temporal lability of ventricular repolarization in patients with and without structural heart disease. J Cardiovasc Electrophysiol 2009;20:873-9.

    24. Cheng A, Calkins H, Berger RD. Managed Ventricular Pacing Below the Lower Rate Limit: Is It Simply Due to Ventricular Based Pacing? Heart Rhythm 2009;6:1240-1.

    25. Chilukuri K, Mayer SA, Scherr D, Dalal D, Abraham T, Henrikson CA, Cheng A, Nazarian S, Sinha S, Spragg D, Berger R, Calkins H, Marine JE. Transesophageal echocardiography predictors of periprocedural cerebrovascular accident in patients undergoing catheter ablation of atrial fibrillation. Europace 2010; in press.

    26. Scherr D, Sharma K, Dalal D, Spragg DD, Chilukuri K, Cheng A, Dong J, Henrikson CA, Nazarian S, Berger RD, Calkins H, Marine JE. Incidence and Predictors of Periprocedural Cerebrovascular Accident in Patients undergoing Catheter Ablation of Atrial Fibrillation. J Cardiovasc Electrophysiol 2009;20:1357-63.

    27. Chilukuri K, Sinha S, Berger RD, Marine JE, Cheng A, Nazarian S, Spragg DD, Calkins H, Henrikson CA. Association of Transseptal Punctures with Isolated Migraine Aura in Patients Undergoing Catheter Ablation of Cardiac Arrhythmias. J Cardiovasc Electrophysiol 2009;20:1227-30.

    28. Tompkins CA, Cheng A, Dalal D, Brinker JA, Leng CT, Marine JE, Nazarian S, Spragg DD, Sinha S, Halperin H, Tomaselli GF, Berger RD, Calkins H, Henrikson CA. Dual Antiplatelet Therapy And Heparin Bridging Significantly Increase the Risk of Bleeding at Device Implantation. J Am Coll Cardiol 2010;55:2376-82.

    29. Chilukuri K, Dukes J, Dalal D, Marine JE, Henrikson CA, Scherr D, Sinha S, Berger R, Cheng A, Nazarian S, Spragg D, Calkins H. Outcomes in patients requiring cardioversion following catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2010;21:27-32.

    30. Chow GV, Hirsch GA, Spragg DD, Cai JX, Cheng A, Ziegelstein RC, Marine JE. Prognostic significance of cardiac troponin I levels in hospitalized patients presenting with supraventricular tachycardia. Medicine 2010;89:141-8.

    31. Spragg DD, Dong J, Fetics BJ, Helm R, Marine JE, Cheng A, Henrikson CA, Kass DA, Berger RD. Optimal left ventricular endocardial pacing sites for cardiac resynchronization therapy in patients with ischemic cardiomyopathy. J Am Coll Cardiol 2010;56:774-81.

    32. Chilukuri K, Dalal D, Gadrey S, Marine JE, Macpherson E, Henrikson CA, Cheng A, Nazarian S, Sinha S, Spragg D, Berger R, Calkins H. A prospective study evaluating the role of obesity and obstructive sleep apnea for outcomes after catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2010;21:521-5.

    33. Cheng A, Wang YF, Curtis JP, Varosy PD. Acute lead dislodgements and in hospital mortality: Findings from the NCDR ICD Registry. J Am Coll Cardiol 2010; 56:1651-6.

    34. Tereshchenko LG, Han L, Cheng A, Marine JE, Spragg DD, Sinha S, Dalal D, Calkins H, Tomaselli GF, Berger RD. Beat-to-beat three-dimensional ECG variability predicts ventricular arrhythmia in ICD recipients. Heart Rhythm 2010;7:1606-13.

    35. Tereshchenko LG, Cheng A, Fetics BJ, Marine JE, Spragg DD, Sinha S, Calkins H, Tomaselli GF, Berger RD. Ventricular arrhythmia is predicted by sum absolute QRST integral but not by QRS width. J Electrocardiol 2010;43:548-52.

    36. Stempniewicz P, Cheng A, Connolly A, Wang XY, Calkins H, Tomaselli G, Berger RD, Tereschenko L. Appropriate and inappropriate electrical therapies delivered by an implantable cardioverter-defibrillator: effect on intracardiac electrogram. J Cardiovasc Electrophysiol 2010; in press.

    37. Cheng A, Nazarian S, Brinker JA, Tompkins C, Spragg DD, Leng CT, Halperin H, Tandri H, Sinha SK, Marine JE, Calkins H, Tomaselli GF, Berger RD, Henrikson CA. Continuation of warfarin during pacemaker or ICD implantation: a randomized clinical trial. Heart Rhythm 2011; in press.

    38. Krebsbach A, Alhumaid F, Henrikson CA, Calkins H, Berger RD, Cheng A. Premature failure of a Riata defibrillator lead: Case report and review of the literature. J Cardiovasc Electrophysiol 2011; in press.

    39. DePonti R, Marazzi R, Ghiringhelli S, Salerno-Uriarte JA, Calkins H, Cheng A. Superiority of simulator-based training compared to conventional training methodologies in the performance of transseptal catheterization. J Am Coll Cardiol 2011; in press.

    40. Tereshchenko LG, Cheng A, Fetics BJ, Butcher B, Marine JE, Spragg DD, Sinha S, Dalal D, Calkins H, Tomaselli GF, Berger RD. A new electrocardiogram marker to identify patients at low risk for ventricular tachyarrhythmias: sum magnitude of the absolute QRST integral. J Electrocardiol 2011; in press.

    41. Cheng A, Nazarian S, Brinker JA, Tompkins C, Spragg DD, Leng CT, Halperin G, Tandri H, Sinha SK, Marine JE, Calkins H, Tomaselli GF, Berger RD, Henrikson CA. Continuation of warfarin during pacemaker or implantable cardioverter-defibrillator implantation: a randomized clinical trial. Heart Rhythm 2011; 8:536-40.

    42. Hoyt H, Nazarian S, Alhumaid F, Dalal D, Chilukuri K, Spragg D, Henrikson CA, Sinha S, Cheng A, Edwards D, Needleman M, Marine JE, Berger RD, Calkins H. Demographic profile of patients undergoing catheter ablation of atrial fibrillation. J Cardiovasc Electrophysiol 2011; in press.

    43. Liang HY, Cheng A, Chang KC, Berger RD, Agarwal K, Eulitt P, Corretti M, Tomaselli GF, Calkins H, Kass DA, Abraham TP. Influence of atrial function and mechanical synchrony on left ventricular hemodynamics in heart failure patients on cardiac resynchronization therapy. J Am Coll Cardiol Img 2011; in press.

    44. Tompkins C, McLean R, Cheng A, Brinker JA, Marine JE, Nazarian S, Spragg DD, Sinha S, Halperin H, Tomaselli GF, Berger RD, Calkins H, Henrikson CA. End-stage renal disease predicts complications in pacemaker and ICD implants. J Cardiovasc Electrophysiol 2011; in press.
  • Academic Affiliations & Courses +
  • Activities & Honors +
  • Videos & Media +

    Videos

    Meet our Experts - Dr. Alen Cheng

    Dr. Cheng is the Director of the Arrhythmia Device Service whose clinical practice focuses on electrophysiology and the implantation and continued care of patients with implanted defibrillators and pacemakers.

  • Upcoming Events +
  • Contact & Locations +

    Locations

    The Johns Hopkins Hospital
    600 N. Wolfe Street
    Carnegie Room 568
    Baltimore, MD 21287
    Phone: 443-287-2939
    Appointment Phone: 443-997-0270
    Fax: 443-873-5019
    Location Map
    Johns Hopkins Medicine - Green Spring Station
    10755 Falls Road
    Pavilion I
    Lutherville, MD 21093
    Phone: 410-583-2740
    Appointment Phone: 443-997-0270
    Fax: 410-583-2741
    Location Map

    Department/Division

    • Medicine - Cardiology
    • Medicine - Electrophysiology

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