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Matthews Chacko, M.D.

Assistant Professor of Medicine


Appointment Phone


Main Location

The Johns Hopkins Hospital

Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

Learn more about our out-of-state patient services »

International Patients

Call +1-410-502-7683 (7a.m. to 6p.m., EST, Mon-Fri)

Learn more about our international patient services »


  • Assistant Professor of Medicine

Centers & Institutes



The Johns Hopkins Hospital

Appointment Phone: 443-997-0270

600 N. Wolfe Street
Sheikh Zayed Tower 7125A
Baltimore, MD 21287 map
Phone: 410-502-0089

Johns Hopkins Outpatient Center

Appointment Phone: 443-997-0270

601 N. Caroline Street
Baltimore, MD 21287 map
Phone: 410-502-9384
Fax: 410-955-5996


Acute Myocardial Infarction, Cardiac Catheterization, Cardiovascular Disease, Cardiovascular Interventions, Carotid Artery Disease, Carotid Artery Stenosis, Carotid Artery Stenting, Chronic Total Coronary Occlusion, Chronic Total Occlusions, Circulatory Support Devices, Coronary Angiography, Coronary Artery Disease, Coronary Artery Stenting, Coronary Care Unit, Emboli-Protection Devices, Endovascular Therapies, Fractional Flow Reserve, Heart Disease, Hypertension, Interventional Cardiology, Intravascular Ultrasound (IVUS), Invasive Cardiology, Laser Atherectomy, Lower Extremity Revascularization, Pericardiocentesis, Peripheral Angiography, Peripheral Arterial Disease, Peripheral Vascular Disease, Renal Artery Disease, Restenosis, Rotational Atherectomy, Trans-Radial Intervention, Trinidad Hopkins Cardiology Program - Interventional Faculty, Valvular Heart Disease, Valvuloplasty for Valvular Stenosis

Research Interests

Renal Artery Stenosis; Valvular Heart Disease; Myocardial Infarction; Refractory Hypertension; Coronary Artery Disease; Peripheral Arterial Disease; Carotid Artery Disease; Acute Coronary Syndromes; Stents; Cardiac Critical Care; Endovascular Interventions; Percutaneous Coronary Intervention


Dr. Matthews Chacko is faculty for interventional cardiologist for the Coronary Care Unit, the Tayer Firm of the Osler and Director of peripheral vascular interventions at the Johns Hopkins Hospital. He specializes in using minimally invasive cardiovascular procedures to help patients who have had a heart attack or are at high risk for one. Dr. Chacko also performs minimally invasive aortic valve replacement (TAVR) surgery. As an assistant professor of medicine, he mentors students to be compassionate practitioners in times of crisis for patients and their families.

Dr. Chacko received his bachelor’s degree from Azusa Pacific University in California and his medical degree from the University of Kansas. He completed his residency at Johns Hopkins and his cardiology fellowship at the Cleveland Clinic. He joined the Johns Hopkins faculty in 2005 as an assistant professor of medicine at the Heart and Vascular institute. Dr. Chacko’s research interests involve finding safer and more effective interventions for cardiovascular diseases. more

Featured Video

Meet our Experts - Dr. Matthews Chacko

    Additional Information

  • Education +


    • University of Kansas School of Medicine / MD (1998)


    • Johns Hopkins University School of Medicine / Medicine (2001)


    • Cleveland Clinic / Cardiology (2005)
    • Cleveland Clinic / Interventional Cardiology (2007)


    • American Board of Internal Medicine / Interventional Cardiology (2006)
  • Research & Publications +

    Selected Publications

    Aaron Horne Jr.; Elizabeth A. Reineck; Rani K. Hasan; Jon R. Resar; Matthews Chacko. Transcatheter aortic valve replacement: Historical perspectives, current evidence, and future directions. American Heart Journal. 2014.

    Aaron Horne; Matthews Chacko. Thrombectomy Devices in Coronary Intervention. Interventional Cardiology Clinics. 2013;2(2):347-359.

    Michael J. Blaha; Gurusher Panjrath; Matthews Chacko; Steven P. Schulman. Localized calcific constrictive pericarditis masquerading as a basal aneurysm. Journal of the American College of Cardiology. 2011;57(18):e65.

    Catherine Y. Campbell; Ashish S. Shah; Matthews Chacko. Inducible left ventricular obstruction after apical-conduit aortic valve bypass surgery. Journal of Thoracic and Cardiovascular Surgery. 2010;140(3):e62-e63.

    Ming Zhang; Niladri Mal; Matthew Kiedrowski; Matthews Chacko; Arman T. Askari; Zoran B. Popovic; Omer N. Koc; Marc S. Penn. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. FASEB Journal. 2007;21(12):3197-3207.

    Stephen G. Ellis; Marc S. Penn; Brian Bolwell; Mario Garcia; Matthews Chacko; Thomas Wang; Kelly J. Brezina; Gerry McConnell; Eric J. Topol. Granulocyte colony stimulating factor in patients with large acute myocardial infarction: Results of a pilot dose-escalation randomized trial. American Heart Journal. 2006;152(6):1051.e9-1051.e14.

    Matthews Chacko; A. Michael Lincoff; Katherine E. Wolski; David J. Cohen; John A. Bittl; Alexandra J. Lansky; Yoshihiro Tsuchiya; Amadeo Betriu; Michael H. Yen; Derek P. Chew; et al. Ischemic and bleeding outcomes in women treated with bivalirudin during percutaneous coronary intervention: A subgroup analysis of the Randomized Evaluation in PCI Linking Angiomax to Reduced Clinical Events (REPLACE)-2 trial. American Heart Journal. 2006;151(5):1039.e1-1039.e7.

    Matthews Chacko; Bruce W Lytle; Richard D White; Robert E Hobbs. Images in cardiovascular medicine. A "mickey mouse" coronary anomaly: aorto-left atrial fistula with aneurysm. Circulation. 2005;111(12):e162-163.

    Matthews Chacko; Nassir F. Marrouche; Deepak L. Bhatt. Asymptomatic acute inferior ST elevation myocardial infarction from thermal injury complicating radiofrequency ablation for atrioventricular re-entrant tachycardia. Journal of Invasive Cardiology. 2004;16(9):504-505.

  • Academic Affiliations & Courses +
  • Activities & Honors +


    • Alpha Omega Alpha (AOA), University of Kansas, 1997
    • Distinguished Alumnus of the Year, Azusa Pacific University, 2013

    Professional Activities

    • Member, Cardiac and Renal Drug Advisory Committee, Food and Drug Administration (FDA)
  • Videos & Media +
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