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Christine Ann Iacobuzio-Donahue, MD

Professor of Pathology
Appointment Phone


Main Location

Johns Hopkins Sidney Kimmel Comprehensive Cancer Center

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Out-of-State & International Patients +
Out of State Patients

Call 410-464-6641 (8a.m. to 6p.m., EST, Mon-Fri)

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Call +1-410-502-0773 (7a.m. to 6p.m., EST, Mon-Fri)

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  • Professor of Pathology

Centers & Institutes

  • Colon Cancer Center
  • Pancreatic Cancer Multidisciplinary Center
  • Sidney Kimmel Comprehensive Cancer Center




  • English
Additional Resources +
  • Education +


    • Boston University School of Medicine ( Boston MA ) (1998)


    • The Johns Hopkins Hospital/ Anatomic Pathology ( Baltimore MD ) (2002)


    • The Johns Hopkins Hospital/ Gastroenterology and Hepatology ( Baltimore MD ) (2002)


    • Anatomic Pathology, American Board of Pathology (2002)
  • Research & Publications +

    Selected Publications

    Rubio-Viqueira, B.; Jimeno, A.; Cusatis, G.; Zhang, X.; Iacobuzio-Donahue, C.; Karikari, C.; Shi, C.; Danenberg, K.; Danenberg, P.V.; Kuramochi, H.; Tanaka, K.; Singh, S.; Salimi-Moosavi, H.; Bouraoud, N.; Amador, M.L.; Altiok, S.; Kulesza, P.; Yeo, C.; Messersmith, W.; Eshleman, J.; Hruban, R.H.; Maitra, A.; Hidalgo, M. An in vivo platform for translational drug development in pancreatic cancer. Clin Cancer Res. 2006 Aug 1;12(15):4652-4661.

    Sebastiani, V.; Ricci, F.; Rubio-Viquiera, B.; Kulesza, P.; Yeo, C.J.; Hidalgo, M.; Klein, A.; Laheru, D.; Iacobuzio-Donahue, C.A. Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival. Clin Cancer Res. 2006 Apr 15;12(8):2492-2497.

    Fu, B.; Guo, M.; Wang, S.; Campagna, D.; Luo, M.; Herman, J.G.; Iacobuzio-Donahue, C.A. Evaluation of GATA-4 and GATA-5 Methylation Profiles in Human Pancreatic Cancers Indicate Promoter Methylation Patterns Distinct from other Human Tumor Types. Cancer Biol Ther. 2007 Jul 7;6(10):1546-1552.

    Kaneda, A.; Wang, C.J.; Cheong, R.; Timp, W.; Onyango, P.; Wen, B.; Iacobuzio-Donahue, C.A.; Ohlsson, R.; Andraos, R.; Pearson, M.A.; Sharov, A.A.; Longo, D.L.; Ko, M.S.; Levchenko, A.; Feinberg, A.P. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20926-20931.

    Cao, D.; Polyak, K.; Halushka, M.K.; Nassar, H.; Kouprina, N.; Iacobuzio-Donahue, C.; Wu, X.; Sukumar, S.; Hicks, J.; De Marzo, A.; Argani, P. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res. 2008;10(5):R91.

    Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Angenendt, P.; Mankoo, P.; Carter, H.; Kamiyama, H.; Jimeno, A.; Hong, S.M.; Fu, B.; Lin, M.T.; Calhoun, E.S.; Kamiyama, M.; Walter, K.; Nikolskaya, T.; Nikolsky, Y.; Hartigan, J.; Smith, D.R.; Hidalgo, M.; Leach, S.D.; Klein, A.P.; Jaffee, E.M.; Goggins, M.; Maitra, A.; Iacobuzio-Donahue, C.; Eshleman, J.R.; Kern, S.E.; Hruban, R.H.; Karchin, R.; Papadopoulos, N.; Parmigiani, G.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26;321(5897):1801-1806.

    Winter, J.M.; Ting, A.H.; Vilardell, F.; Gallmeier, E.; Baylin, S.B.; Hruban, R.H.; Kern, S.E.; Iacobuzio-Donahue, C.A. Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer. Clin Cancer Res. 2008 Jan 15;14(2):412-418.

    Blackford, A.; Parmigiani, G.; Kensler, T.W.; Wolfgang, C.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Klein, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Vogelstein, B.; Velculescu, V.E.; Kinzler, K.W.; Hruban, R.H. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15;69(8):3681-3688.

    Blackford, A.; Serrano, O.K.; Wolfgang, C.L.; Parmigiani, G.; Jones, S.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Leary, R.J.; Eshleman, J.R.; Goggins, M.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Cameron, J.L.; Olino, K.; Schulick, R.; Winter, J.; Herman, J.M.; Laheru, D.; Klein, A.P.; Vogelstein, B.; Kinzler, K.W.; Velculescu, V.E.; Hruban, R.H. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15;15(14):4674-4679.

    Glockner, S.C.; Dhir, M.; Yi, J.M.; McGarvey, K.E.; Van Neste, L.; Louwagie, J.; Chan, T.A.; Kleeberger, W.; de Bruine, A.P.; Smits, K.M.; Khalid-de Bakker, C.A.; Jonkers, D.M.; Stockbrugger, R.W.; Meijer, G.A.; Oort, F.A.; Iacobuzio-Donahue, C.; Bierau, K.; Herman, J.G.; Baylin, S.B.; Van Engeland, M.; Schuebel, K.E.; Ahuja, N. Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer. Cancer Res. 2009 Jun 1;69(11):4691-4699.

    Hristov, A.C.; Cope, L.; Reyes, M.D.; Singh, M.; Iacobuzio-Donahue, C.; Maitra, A.; Resar, L.M. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Mod Pathol. 2009 Jan;22(1):43-49.

    Jones, S.; Hruban, R.H.; Kamiyama, M.; Borges, M.; Zhang, X.; Parsons, D.W.; Lin, J.C.; Palmisano, E.; Brune, K.; Jaffee, E.M.; Iacobuzio-Donahue, C.A.; Maitra, A.; Parmigiani, G.; Kern, S.E.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Eshleman, J.R.; Goggins, M.; Klein, A.P. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10;324(5924):217.

    Yoshimura, K.; Meckel, K.F.; Laird, L.S.; Chia, C.Y.; Park, J.J.; Olino, K.L.; Tsunedomi, R.; Harada, T.; Iizuka, N.; Hazama, S.; Kato, Y.; Keller, J.W.; Thompson, J.M.; Chang, F.; Romer, L.H.; Jain, A.; Iacobuzio-Donahue, C.; Oka, M.; Pardoll, D.M.; Schulick, R.D. Integrin alpha2 mediates selective metastasis to the liver. Cancer Res. 2009 Sep 15;69(18):7320-7328.

    Campbell, P.J.; Yachida, S.; Mudie, L.J.; Stephens, P.J.; Pleasance, E.D.; Stebbings, L.A.; Morsberger, L.A.; Latimer, C.; McLaren, S.; Lin, M.L.; McBride, D.J.; Varela, I.; Nik-Zainal, S.A.; Leroy, C.; Jia, M.; Menzies, A.; Butler, A.P.; Teague, J.W.; Griffin, C.A.; Burton, J.; Swerdlow, H.; Quail, M.A.; Stratton, M.R.; Iacobuzio-Donahue, C.; Futreal, P.A. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010 Oct 28;467(7319):1109-1113.

    Dhir, M.; Yachida, S.; Van Neste, L.; Glockner, S.C.; Jeschke, J.; Pappou, E.P.; Montgomery, E.A.; Herman, J.G.; Baylin, S.B.; Iacobuzio-Donahue, C.; Ahuja, N. Sessile serrated adenomas and classical adenomas: An epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract. Int J Cancer. 2010 Dec 10.

    Garrido-Laguna, I.; Tan, A.C.; Uson, M.; Angenendt, M.; Ma, W.W.; Villaroel, M.C.; Zhao, M.; Rajeshkumar, N.V.; Jimeno, A.; Donehower, R.; Iacobuzio-Donahue, C.; Barrett, M.; Rudek, M.A.; Rubio-Viqueira, B.; Laheru, D.; Hidalgo, M. Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer. Br J Cancer. 2010 Aug 24;103(5):649-655.

    He, Y.; Wu, J.; Dressman, D.C.; Iacobuzio-Donahue, C.; Markowitz, S.D.; Velculescu, V.E.; Diaz, L.A., Jr.; Kinzler, K.W.; Vogelstein, B.; Papadopoulos, N. Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature. 2010 Mar 25;464(7288):610-614.

    Hristov, A.C.; Cope, L.; Di Cello, F.; Reyes, M.D.; Singh, M.; Hillion, J.A.; Belton, A.; Joseph, B.; Schuldenfrei, A.; Iacobuzio-Donahue, C.A.; Maitra, A.; Resar, L.M. HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010 Jan;23(1):98-104.

    Messersmith, W.A.; Jimeno, A.; Jacene, H.; Zhao, M.; Kulesza, P.; Laheru, D.A.; Kahn, Y.; Spira, A.; Dancey, J.; Iacobuzio-Donahue, C.; Donehower, R.C.; Carducci, M.; Rudek, M.A.; Hidalgo, M. Phase I trial of oxaliplatin, infusional 5-fluorouracil, and leucovorin (FOLFOX4) with erlotinib and bevacizumab in colorectal cancer. Clin Colorectal Cancer. 2010 Dec;9(5):297-304.

    Poultsides, G.A.; Reddy, S.; Cameron, J.L.; Hruban, R.H.; Pawlik, T.M.; Ahuja, N.; Jain, A.; Edil, B.H.; Iacobuzio-Donahue, C.A.; Schulick, R.D.; Wolfgang, C.L. Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas. Ann Surg. 2010 Mar;251(3):470-476.

    Rasheed, Z.A.; Yang, J.; Wang, Q.; Kowalski, J.; Freed, I.; Murter, C.; Hong, S.M.; Koorstra, J.B.; Rajeshkumar, N.V.; He, X.; Goggins, M.; Iacobuzio-Donahue, C.; Berman, D.M.; Laheru, D.; Jimeno, A.; Hidalgo, M.; Maitra, A.; Matsui, W. Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma. J Natl Cancer Inst. 2010 Mar 3;102(5):340-351.

    Scharpf, R.B.; Iacobuzio-Donahue, C.A.; Cope, L.; Ruczinski, I.; Garrett-Mayer, E.; Lakkur, S.; Campagna, D.; Parmigiani, G. Cross-platform Comparison of Two Pancreatic Cancer Phenotypes. Cancer Inform. 2010;9:257-264.

    Yachida, S.; Jones, S.; Bozic, I.; Antal, T.; Leary, R.; Fu, B.; Kamiyama, M.; Hruban, R.H.; Eshleman, J.R.; Nowak, M.A.; Velculescu, V.E.; Kinzler, K.W.; Vogelstein, B.; Iacobuzio-Donahue, C.A. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature. 2010 Oct 28;467(7319):1114-1117.
  • Academic Affiliations & Courses +
  • Activities & Honors +
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  • Contact & Locations +


    Johns Hopkins Sidney Kimmel Comprehensive Cancer Center
    401 N. Broadway
    CRB2 Room 343
    Baltimore, MD 21231
    Phone: 410-955-3511
    Appointment Phone: 410-955-3511
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    • Pathology

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